To Examine Whether Urinary Partial Oxygen Pressure Measurements Are Indicative of the Postoperative Occurrence of Acute Kidney Injury (AKI) in Individuals Who Have Undergone Liver Transplantation

NCT06121167 | Not Yet Recruiting DMC

• 1 other identifier: MB1
• Study Type: observational
• Target: 98
• Locations: 0 countries
• Sites: N/A

Brief Summary

Postoperative acute kidney injury (AKI) is a frequent occurrence among liver transplant recipients and results in considerable mortality and morbidity. The delayed increase in plasma creatinine levels and its susceptibility to external influences, which are utilized in the current diagnostic criteria for AKI, contribute to diagnostic delays. Therefore, numerous biomarkers, including KIM-1, NGAL, TIMP-2, and CYSTATIN C in plasma, along with urine partial oxygen pressure levels and NGAL, are currently under examination to identify acute kidney injury at its early stage. It is well-established that the renal medulla is highly susceptible to hypoxia, which may consequently lead to acute kidney injury. A range of studies have also demonstrated that urine partial oxygen pressure is capable of providing valuable insights into the oxygenation state of the renal medulla. Although urine oxygen pressure measurement is not commonly used, unlike blood gas analysis, urine partial oxygen pressure measurement dates back to 1964. Research among cardiopulmonary bypass patients suggests a correlation between urine partial oxygen pressure data and acute kidney injury. Therefore, we hypothesize that monitoring urine partial oxygen pressure levels may offer insight into the development of acute kidney injury in liver transplant recipients.

Conditions

Acute Kidney Injury

Keywords

acute kidney injrury; liver transplantation; urine partial oxygen pressure

Outcome Measures

Primary Outcomes (1)

• acute kidney injury

  whether urinary oxygen partial pressure can predict acute kidney injury

  first 7 days

Secondary Outcomes (1)

• mortality

  28. days

Study Arms (2)

study group

patients with acute kidney injury

Diagnostic Test: urinary partial oxygen pressure

control group

patients who do not develop acute kidney injury

Diagnostic Test: urinary partial oxygen pressure

Interventions

urinary partial oxygen pressure DIAGNOSTIC_TEST

arterial blood gas

control group; study group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

liver transplant recipients

You may qualify if:

• patients aged between 18 and 65 years
• elective liver transplantation

You may not qualify if:

• Patients who do not want to participate in the study,
• patients who will be transplanted due to fulminant hepatic failure,
• patients with hepatic encephalopathy,
• patients with hepatorenal or hepatopulmonary syndrome,
• patients with previous lung
• heart disease

Sponsors & Collaborators

• Inonu University: lead

Related Publications (3)

• Tosun M, Ulugol H, Aksu U, Toraman F. Can Partial Oxygen Pressure of Urine be an Indicator for Tissue Perfusion? Turk J Anaesthesiol Reanim. 2019 Jun;47(3):187-191. doi: 10.5152/TJAR.2019.89083. Epub 2019 Jan 29.

  PMID: 31183464 BACKGROUND

• Silverton NA, Lofgren LR, Hall IE, Stoddard GJ, Melendez NP, Van Tienderen M, Shumway S, Stringer BJ, Kang WS, Lybbert C, Kuck K. Noninvasive Urine Oxygen Monitoring and the Risk of Acute Kidney Injury in Cardiac Surgery. Anesthesiology. 2021 Sep 1;135(3):406-418. doi: 10.1097/ALN.0000000000003663.

  PMID: 34329393 BACKGROUND

• Stafford-Smith M. Could Trended Oxygen Partial Pressure in the Urine Be the "ST Segment" Kidney Monitor We've Been Looking For? Anesthesiology. 2021 Sep 1;135(3):380-381. doi: 10.1097/ALN.0000000000003869. No abstract available.

  PMID: 34329391 RESULT

MeSH Terms

Conditions

Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Central Study Contacts

murat bıçakcıoğlu

CONTACT

05327901791; drmuratft@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Asistant prof

Study Record Dates

• First Submitted: November 2, 2023
• First Posted: November 7, 2023
• Study Start: March 6, 2024
• Primary Completion: May 10, 2024
• Study Completion: July 15, 2024
• Last Updated: March 7, 2024

Record last verified: 2024-03