CMR in Myocardial Infarction with Nonobstructive Coronary Arteries

NCT06502899 | Completed

• 1 other identifier: CMR in MINOCA
• Study Type: observational
• Target: 387
• Locations: 1 country
• Sites: 1

Brief Summary

MINOCA is accompanied by a worse prognosis, which is related to the inability to clarify the etiology.CMR has been explicitly recommended by guidelines as an etiologic diagnostic tool for MINOCA. Although CMR-related parameters, such as strain and ECV, have been shown to be associated with prognosis in patients with myocardial infarction. However, the relationship between CMR-strain or ECV and MINOCA is unclear. The aim of this study was to investigate the characterization of CMR-strain or ECV in patients with MINOCA and the relationship with prognosis.

Conditions

Cardiac Magnetic Resonance; Myocardial Infarction with Nonobstructive Coronary Arteries; Strain; Extracellular Volume

Outcome Measures

Primary Outcomes (1)

• Primary endpoint events included any cause, non-fatal infarction, stroke, or cardiac readmission.

  All patients were followed until June 30, 2024

Study Arms (1)

diagnosed with MINOCA and completed with cardiac magnetic resonance

Other: Cardiac MRI

Interventions

Cardiac MRI OTHER

Patients with a diagnosis of MINOCA and completed CMR were included in this study

diagnosed with MINOCA and completed with cardiac magnetic resonance

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We consecutively selected patients who were suspected of myocardial infarction with concomitant CAG from January 2019 to June 2024 at the Affiliated Hospital of Xuzhou Medical University. All patients completed CMR during hospitalization. hsTnT peak was above the 99th percentile and CAG less than 50% in all patients.

You may qualify if:

• Complete CMR during hospitalization;
• CAG results suggesting coronary stenosis of less than 50%;
• peak hsTnT above the 99th percentile.

You may not qualify if:

• CMR image sequences are missing or of poor quality.

Sponsors & Collaborators

• The Affiliated Hospital of Xuzhou Medical University: lead

Study Sites (1)

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, 221002, China

Location

Related Publications (3)

• Abdu FA, Chen L, Qiu B, Liu L, Mohammed AQ, Lv X, Yin G, Zhang W, Alifu J, Chen W, Lu Y, Che W. Prognostic Impact of Infarct Size and Coronary Microvascular Function Via Cardiovascular Magnetic Resonance and Coronary Angiography-Derived Index of Microcirculatory Resistance in Myocardial Infarction With Nonobstructive Coronary Arteries. J Am Heart Assoc. 2026 Jan 6;15(1):e043169. doi: 10.1161/JAHA.125.043169. Epub 2025 Dec 18.

  PMID: 41413401 DERIVED

• Chen L, Ge L, Abdu FA, Du X, Liu J, Chen W, Lu Y, Che W. Prognostic value of CMR-derived extracellular volume in myocardial infarction with non-obstructive coronary arteries. Int J Cardiol. 2025 Oct 15;437:133528. doi: 10.1016/j.ijcard.2025.133528. Epub 2025 Jun 18.

  PMID: 40541789 DERIVED

• Chen L, Qiu B, Abdu FA, Liu L, Zhang W, Wang C, Alifu J, Qi P, Che W, Lu Y. Prognostic Value of Strain by Tissue Tracking Cardiac Magnetic Resonance in Myocardial Infarction With Nonobstructive Coronary Arteries. J Am Heart Assoc. 2025 Apr 15;14(8):e039395. doi: 10.1161/JAHA.124.039395. Epub 2025 Apr 7.

  PMID: 40194976 DERIVED

MeSH Terms

Conditions

MINOCA; Sprains and Strains

Condition Hierarchy (Ancestors)

Myocardial Infarction; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Wounds and Injuries

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 9, 2024
• First Posted: July 16, 2024
• Study Start: January 1, 2019
• Primary Completion: June 30, 2024
• Study Completion: July 9, 2024
• Last Updated: July 16, 2024

Record last verified: 2024-07

Locations

CN (1)