Extracellular Volume Associated With New-Onset Atrial Fibrillation

NCT06447857 | Completed

• 1 other identifier: XYFY2024-KL189-01
• Study Type: observational
• Target: 589
• Locations: 1 country
• Sites: 1

Brief Summary

Left ventricular fibrosis is strongly associated with atrial fibrillation (AF). However, the relationship between LV fibrosis and new-onset AF (NOAF) after ST-segment elevation myocardial infarction (STEMI) is currently unknown. This study was to investigate the relationship between different regions of ECV and NOAF during the acute phase of STEMI. ECV in integral (integral ECV), non-myocardial infarction region (NMI-ECV) and myocardial infarction region (MI-ECV) was obtained by CMR.

Conditions

Cardiac Magnetic Resonance; Extracellular Volume Overload; Myocardial Infarction; Atrial Fibrillation

Outcome Measures

Primary Outcomes (1)

• Primary endpoint events included new-onset atrial fibrillation

  NOAF was defined as post-admission atrial fibrillation without a history of atrial fibrillation. ECG monitoring revealed a suspicious rhythm during admission, and an immediate 12-lead ECG confirmed NOAF.

  during hospitalization (assessed up to 10 days)

Study Arms (1)

STEMI underwent CMR

This retrospective study included patients diagnosed with STEMI at the Affiliated Hospital of Xuzhou Medical University.

Other: Cardiac MRI

Interventions

Cardiac MRI OTHER

This retrospective study included patients diagnosed with STEMI at the Affiliated Hospital of Xuzhou Medical University. All patients underwent CMR.

STEMI underwent CMR

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This retrospective study included patients diagnosed with STEMI at the Affiliated Hospital of Xuzhou Medical University from January 2020 to May 2024. All patients underwent CMR during hospitalization, which included T1 mapping sequences. The blood sampling was collected within 24 hours of the CMR examination. NOAF was defined as post-admission atrial fibrillation without a history of atrial fibrillation. ECV in integral (integral ECV), non-myocardial infarction region (NMI-ECV) and myocardial infarction region (MI-ECV) was obtained by CMR.

You may qualify if:

• Successful pPCI (TIMI flow ≥ 2) within 12 hours after symptom onset
• Admission to the cardiac care unit for continuous electrocardiogram (ECG) monitoring after pPCI

You may not qualify if:

• Poor image quality
• History of myocardial infarction
• History of atrial fibrillation
• Malignancy, or inflammatory disease
• Severe valvular heart disease
• Thyroid dysfunction

Sponsors & Collaborators

• The Affiliated Hospital of Xuzhou Medical University: lead

Study Sites (1)

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, 221002, China

Location

MeSH Terms

Conditions

Myocardial Infarction; Atrial Fibrillation

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Arrhythmias, Cardiac

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 31, 2024
• First Posted: June 7, 2024
• Study Start: January 1, 2020
• Primary Completion: May 31, 2024
• Study Completion: May 31, 2024
• Last Updated: June 7, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)