Assessment of the Efficacy of Microosteoperforations Versus Injectable Platelet-rich Fibrin During Orthodontic Leveling and Alignment of Mandibular Incisors

NCT06498609 | Enrolling By Invitation

• 1 other identifier: 1001/3560
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this prospective clinical study will be to compare the efficacy of micro osteoperforations versus injectable platelet-rich fibrin during orthodontic leveling and alignment of mandibular incisors.

Conditions

Effect of Platelet Rich Fibrin Versus Microosteoperforation Compaed to Control Group Toothmovement

Outcome Measures

Primary Outcomes (1)

• assessment of acceleration of leveling and alignment of mandibular incisors

  rate of leveling and alignment

  post interventional at 4months

Study Arms (3)

Microosteoperforation

EXPERIMENTAL

MOPs with leveling and alignment that will be performed tow time according to standardized protocol

Procedure: MOPs with leveling and alignment

Injectable platelet rich fibrin

EXPERIMENTAL

i-PRF with leveling and alignment that will be performed tow time according to standardized protocol

Biological: iprf

control group

NO INTERVENTION

leveling and alignment that will be performed without any intervention

Interventions

iprf BIOLOGICAL

i-PRF with leveling and alignment

Injectable platelet rich fibrin

MOPs with leveling and alignment PROCEDURE

mop

Microosteoperforation

Eligibility Criteria

• Age: 15 Years - 25 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• An age range from 15 to 25 years.
• Participants who had a full set of permanent dentitions excluding the third molar.
• Participants who had moderate crowding in the mandibular arch according to Little's irregularity index that necessitates non-extraction treatment in the mandibular arch.
• Normal vertical facial proportions.
• Participants who had good oral hygiene and no periodontal disease.
• No systemic diseases or regular medication that could interfere and/or affect orthodontic teeth movement.
• No evidence of craniofacial anomalies, such as clef lip and palate or previous history of trauma, bruxism, or parafunction.
• No tooth size, shape, or root abnormalities visible on patient's radiographic records.

You may not qualify if:

• Previous orthodontic treatment.
• Any skeletal dysplasia or craniofacial malformation.
• Retained primary or missing permanent teeth in the anterior area, and any kind of tooth/root shape anomaly or history of trauma affecting the incisors.
• Systemic diseases or regular use of medications that could interfere with OTM.
• Patients with root resorption, impacted canines, or dental anomalies.
• Poor oral hygiene and uncontrolled periodontal diseases.

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

Alazhar University

Cairo, Egypt

Location

MeSH Terms

Interventions

morpholinopropane sulfonic acid

Study Officials

• Hasan Fares, Student

  Al-Azhar University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: July 7, 2024
• First Posted: July 12, 2024
• Study Start: August 1, 2024
• Primary Completion: November 1, 2024
• Study Completion: December 1, 2024
• Last Updated: July 12, 2024

Record last verified: 2024-05

Locations

EG (1)