Investigation of the Effect of I-PRF Application on Pain in Alveolitis

NCT06761001 | Completed

• 1 other identifier: EskisehirOU-TEKIN-001
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Literature review showed that there are no studies on the use of i-PRF in alveolitis cases. The aim of this study was to investigate the effect of i-PRF on the treatment of alveolitis. The hypothesis of the study was that i-PRF applied to alveolitis patients would reduce pain.

Conditions

Alveolar Osteitis; Pain; Dry Socket

Keywords

injectable platelet rich fibrine

Outcome Measures

Primary Outcomes (1)

• Change in post-operative pain assessed: visual analog (VAS) scale

  VAS measured on a 10cm scale, where 0 represents no pain and 10 represents maximum pain

  postoperative 3rd, and 7th days

Study Arms (2)

I-PRF

EXPERIMENTAL

I-PRF Application

Device: I-PRF

Standard treatment

ACTIVE COMPARATOR

standard treatment

Other: Control

Interventions

I-PRF DEVICE

After local anesthesia is injected, alveolar curettage is performed and the socket is irrigated with saline solution. I-PRF is given to patients in the experimental group.

I-PRF

Control OTHER

After local anesthesia is injected, alveolar curettage is performed and the socket is irrigated with saline solution.

Standard treatment

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy individuals without systemic disease Patients with complete data and attending their appointments

You may not qualify if:

• Patients who smoke Pregnant or breastfeeding female patients with bleeding disorders and diabetics Patients currently or previously using bisphosphonates or receiving radiotherapy to the jaw Patients unable to consent to participate in the study

Sponsors & Collaborators

• Eskisehir Osmangazi University: lead

Study Sites (1)

Eskişehir Osmangazi University

Eskişehir, 26480, Turkey (Türkiye)

Location

Related Publications (4)

• Uranbey O, Ayranci F. How effective are concentrated growth factor and injectable platelets in reducing complications following impacted third molar surgery? Quintessence Int. 2024 May 30;55(5):380-390. doi: 10.3290/j.qi.b5213477.

  PMID: 38619256 RESULT

• Laforgia A, Inchingolo AD, Riccaldo L, Avantario P, Buongiorno S, Malcangi G, Bordea IR, Palermo A, Inchingolo F, Inchingolo AM, Dipalma G. The Use of Platelet-Rich Fibrin (PRF) in the Management of Dry Socket: A Systematic Review. Int J Mol Sci. 2024 Sep 19;25(18):10069. doi: 10.3390/ijms251810069.

  PMID: 39337554 RESULT

• Sharma A, Aggarwal N, Rastogi S, Choudhury R, Tripathi S. Effectiveness of platelet-rich fibrin in the management of pain and delayed wound healing associated with established alveolar osteitis (dry socket). Eur J Dent. 2017 Oct-Dec;11(4):508-513. doi: 10.4103/ejd.ejd_346_16.

  PMID: 29279679 RESULT

• Tekin G, Turedi SO. Is injectable platelet-rich fibrin really effective in alveolar osteitis? a randomised controlled clinical trial. BMC Oral Health. 2025 May 26;25(1):804. doi: 10.1186/s12903-025-06257-y.

  PMID: 40420265 DERIVED

MeSH Terms

Conditions

Dry Socket; Pain

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Görkem TEKİN, Assist.Prof.

  Eskişehir Osmangazi University Faculty of Dentistry

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Asst.Prof.

Study Record Dates

• First Submitted: December 30, 2024
• First Posted: January 7, 2025
• Study Start: October 20, 2024
• Primary Completion: February 18, 2025
• Study Completion: February 18, 2025
• Last Updated: February 19, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)