Influence of Injectable Platelet Rich Fibrin on Different Orthodontic Tooth Movements During Clear Aligner Therapy

NCT06380946 | Enrolling By Invitation

• 1 other identifier: 978/91
• Study Type: interventional
• Target: 78
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this prospective clinical project will be to assess the effect of platelet rich fibrin on the rate of different orthodontic tooth movements during clear aligner therapy.

Conditions

Effect of Platelet Rich FibrinDuring Clear Aligner Therapy

Outcome Measures

Primary Outcomes (1)

• Influence of injectable platelet rich fibrin rate of different orthodontic tooth movements by millimeter

  rate of orthodontic tooth movement by millimeter

  post interventionalal at 6months

Study Arms (8)

Experimental:iPRF group closure of premolar extraction space

EXPERIMENTAL

closure ofpremolar extraction space that will be performed with iPRFapplication according to a standardized protocol

Biological: iPRF

intervention group

NO INTERVENTION

iPRFgroup closure of premolar extraction space control side

Experimental: iPRFgroup: distalization intervntion side

EXPERIMENTAL

distalization will be commenced with application of iPRF according to a standardized protocol

Biological: iPRF

No Intervention: iPRF group: distalization control side

NO INTERVENTION

distalization will be commenced without application of iPRF according to a standardized protocol

Experimental: iPRF group: leveling and alignment

EXPERIMENTAL

leveling and alignment be commenced with application of iPRF according to a standardized protocol

Biological: iPRF

No Intervention: leveling and alignment without intervention

NO INTERVENTION

leveling and alignment without intervention

Experimental: iPRF group: Intrusion

EXPERIMENTAL

intrusion assisted with application of iPRF according to a standardized protocol

Biological: iPRF

No Intervention: intrusion control group

NO INTERVENTION

intrusion without intervention

Interventions

iPRF BIOLOGICAL

iPRF has been found to speed up OTM by stimulating the RANK/RANKL/OPG system to initiate osteoclast formation.

Also known as: injectaleplatelets rich fibrin

Experimental: iPRF group: Intrusion; Experimental: iPRF group: leveling and alignment; Experimental: iPRFgroup: distalization intervntion side; Experimental:iPRF group closure of premolar extraction space

Eligibility Criteria

• Age: 15 Years - 22 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• \. Age ranges from 15 to 22 years. 2. Bilateral Class II molar relationship. 3. Skeletal Class I or mild Class II relationship. 4. Normal or decreased vertical height. 5. No posterior crowding or spaces. 6. Fully erupted maxillary first and second molars. 7. Congenitally missing or extracted third molars. 8. Good oral hygiene. 9. Absence of any periodontal disease and alveolar bone loss. 10. Absence of medications that may inhibit orthodontic movement
• initial bonding appointment; 6. No required management with interproximal stripping, inter-maxillary elastics, open NiTi springs, and removable or extra-oral devices. Canine retraction Eligibility criteria
• Age, 15 to 25 years; Class ii division 1 malocclusion with mild or no crowding; No previous orthodontic treatment; No systemic disease that might have affected bone formation or density, such as osteoporosis, hyperparathyroidism, or vitamin d deficiency; Adequate oral hygiene; Probing depth values not exceeding 3 mm across the Entire dentition; Adequate thickness of the attached gingiva (1-2 mm); No radiographic evidence of bone loss

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

AlAzhar university

Cairo, Egypt

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: prinicpaI Investigator

Study Record Dates

• First Submitted: April 19, 2024
• First Posted: April 24, 2024
• Study Start: June 1, 2024
• Primary Completion: October 1, 2024
• Study Completion: November 1, 2024
• Last Updated: April 24, 2024

Record last verified: 2024-04

Locations

EG (1)