Asia Pediatric Intensive Care Epidemiology and Outcomes Study
AsiaPedIC
1 other identifier
observational
10,000
2 countries
2
Brief Summary
The overall objective of this study is to improve the standard of care of critically ill pediatric patients. The specific aims are to describe the clinical profile and outcomes of all admissions to Asian pediatric ICUs, determine the risk factors associated with poor outcomes, determine quality indicators for benchmarking ICU performance across sites and develop and train artificial intelligence algorithms to predict mortality, length of ICU stay and resource utilization.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Aug 2024
Typical duration for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 25, 2024
CompletedFirst Posted
Study publicly available on registry
July 1, 2024
CompletedStudy Start
First participant enrolled
August 1, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 31, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2027
April 8, 2026
August 1, 2025
2.7 years
June 25, 2024
April 2, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Mortality
ICU mortality and time based mortality
Including 28-days and 60-days
Secondary Outcomes (6)
Ventilator duration
Including 28-days and 60-days
ICU duration
Including 28-days and 60-days
Nosocomial infections
Throughout ICU stay including 28-days and 60-days
Accidental extubations
Throughout ICU stay including 28-days and 60-days
Line associated thrombosis
Throughout ICU stay including 28-days and 60-days
- +1 more secondary outcomes
Other Outcomes (2)
Resource utilisation
Throughout ICU stay including 28-days and 60-days
Cardiopulmonary resuscitation
Throughout ICU stay including 28-days and 60-days
Study Arms (1)
Pediatric critical illness
All admissions to the pediatric ICU of participant hospitals without restriction to age, gender or race/ethnicity. Patients who have previously consented under the Singapore Pediatric Intensive Care Registry (SG-PedIC) under a similar single-center study protocol which started from 2020 will also be included.
Eligibility Criteria
Though the main methodology is recruitment of all pediatric ICU admissions, a pre-determined random sampling protocol is allowed for sites with limited in resources for recruitment and data collection. This protocol may involve recruitment of all admissions for 1year (52 weeks), all admissions for 1 month per quarter over 1 year (16 weeks), all admissions for 1 week per month over 1 year (12 weeks), all admissions for 2 weeks per quarter over 1 year (8 weeks) or all admissions for 1 week for quarter over 1 year (4 weeks) - this will be declared at the start of the study by each participating site before recruitment begins. This strategy will allow us to include sites with and without sufficient resources to be represented in this study.
You may qualify if:
- All patients admitted to the pediatric ICUs of participant hospitals
You may not qualify if:
- No consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- KK Women's and Children's Hospitallead
- King Chulalongkorn Memorial Hospitalcollaborator
- Tengku Ampuan Rahimah Hospitalcollaborator
- King Abdullah Specialized Children's Hospitalcollaborator
- Children's Hospital 2collaborator
- University Malaysia Medical Centrecollaborator
- Saiful Anwar Hospitalcollaborator
- Murni Teguh Memorial Hospitalcollaborator
- Siriraj Hospitalcollaborator
- Harapan Kita Women and Children Hospitalcollaborator
- Vicente Sotto Memorial Medical Centercollaborator
- Hong Kong Children's Hospitalcollaborator
- Ramathibodi Hospitalcollaborator
- Aga Khan Universitycollaborator
- Aichi Children's Health and Medical Center, Japancollaborator
- Hospital Sultanah Aminah Johor Bahrucollaborator
- Prof IGNG Ngoerah Hospitalcollaborator
- Penang Hospital, Malaysiacollaborator
- Vietnam National Children's Hospitalcollaborator
- Hospital Pakar Kanak-kanak UKMcollaborator
- National University Hospital, Singaporecollaborator
- Queen Elizabeth Hospital, Hong Kongcollaborator
- Children's Hospital of Chongqing Medical Universitycollaborator
- Shanghai Children's Medical Centercollaborator
Study Sites (2)
K K Women's and Children's Hospital
Singapore, Singapore
King Chulalongkorn Memorial Hospital
Bangkok, Thailand
Biospecimen
Blood, deep tracheal lavage, bronchoalveoalr lavage, respiratory and oropharyngeal swabs, surface swabs, stools.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Judith Ju Ming Wong
K K Women's and Children's Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr
Study Record Dates
First Submitted
June 25, 2024
First Posted
July 1, 2024
Study Start
August 1, 2024
Primary Completion (Estimated)
March 31, 2027
Study Completion (Estimated)
December 31, 2027
Last Updated
April 8, 2026
Record last verified: 2025-08