Estimate the Relationship Between Oral Microbiota and Stroke

NCT06479915 | Completed DMC

• 1 other identifier: SHFMU
• Study Type: observational
• Target: 170
• Locations: 1 country
• Sites: 2

Brief Summary

Oral bacteria constitute the second largest population of the human microbiome. Recent studies have identified their role in the development of systemic diseases, such as cardiovascular and cerebrovascular diseases. Streptococcus Mutans (SM) is considered the primary pathogen responsible for dental caries. Furthermore, in cases of oral inflammatory diseases, SM has been found to invade the bloodstream and disseminate, leading to systemic diseases. Against this backdrop, this study aims to investigate disparities in oral flora between stroke patients and healthy individuals by collecting saliva samples from both groups.

Conditions

Stroke; Microbial Disease

Keywords

cnm; Streptococcus mutans; Cerebal microbleeds; Cerebral hemorrhage; Cerebral ischemia; cnm-positive streptococcus mutans

Outcome Measures

Primary Outcomes (2)

• Estimate the Relationship Between Oral Microbiota and Stroke

  Measure the diversity and abundance of oral bacteria in stroke patients,units:Number of bacterial species, bacterial counts (CFU/ml)

  2025.06

• Correlation Between Oral Microbiota and Cerebral Microbleeds in Stroke

  Number and volume of microbleeds (measured in mm³)

  2025.06

Study Arms (2)

Stroke

Small cerebral vessel disease

healthy people

MRI showed no signs of small cerebral vessel disease

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

small cerebral vessel disease

You may qualify if:

• \. Microbleeding/damage or rupture of small blood vessels in the brain has been diagnosed within the past 365 days 2. Have done nuclear magnetic examination and can provide nuclear magnetic results

You may not qualify if:

• Have received antibiotic quality within the last three months

Sponsors & Collaborators

• Fujian Medical University: lead
• First Affiliated Hospital of Fujian Medical University: collaborator

Study Sites (2)

School and Hospital of stomatology,Fujian Medical University,Fuzhou,Fujian Province,350002,China

Fuzhou, Fujian, 350002, China

Location

The First Affiliated Hospital of Fujian Medical University

Fuzhou, Fujian, 350002, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

Saliva;dental plaque

MeSH Terms

Conditions

Stroke; Cerebral Hemorrhage; Brain Ischemia

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Intracranial Hemorrhages; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• XiaoJing Huang

  School and Hospital of Stomatology,Fujian Medical University,fuzhou,Fujian Province,350002,China

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Archiater

Study Record Dates

• First Submitted: June 19, 2024
• First Posted: June 28, 2024
• Study Start: April 1, 2024
• Primary Completion: February 28, 2025
• Study Completion: June 30, 2025
• Last Updated: August 7, 2025

Record last verified: 2025-08

Locations

CN (2)