Neural Changes in Stroke Patients During Challenging Walking Tasks.

NCT06764290 | Recruiting

• 1 other identifier: 2024018-1
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 2

Brief Summary

For stroke patients, a challenging, unfamiliar, and more difficult task may increase the likelihood of brain activation to stimulate recovery. Pedal walking and walking with eyes-covered are both difficult and challenging tasks for stroke patients. The investigators intend to study the biomechanics and neural mechanisms of challenging pedal walking and walking with eyes covered. Stroke participants will wear electroencephalogram electrode caps and perform three tasks: walking on a flat surface for 60 seconds, walking on pedal for 60 seconds, and walking with eyes covered for 60 seconds.

Conditions

Stroke

Keywords

Electroencephalography; gait rehablitation; challenging task

Outcome Measures

Primary Outcomes (2)

• Weight Phase Lag Index

  The Weighted Phase Lag Index (WPLI) is a measure used to quantify phase synchronization in electrophysiological data.Continuously measure the connectivity of the coupling of neural oscillatory activity in the brain, while being statistically more powerful in detecting changes in signal phase synchronization.The WPLI ranges from 0 to 1, with 0 indicating no phase synchronization and 1 indicating complete phase synchronization.

  The study was an observational cross-sectional study with data collected at the same time as the trial was being conducted, so the duration was 60 seconds

• Relative power

  The electroencephalogram signal in the time domain is converted into the relevant information in the frequency domain, the frequency bands are divided, and the relative power results of each channel in each frequency band are derived. Among them, delta:1-4Hz, theta:4-8Hz, alpha:8-15Hz, beta:15-30Hz, gamma:30-45Hz.

  The study was an observational cross-sectional study with data collected at the same time as the trial was being conducted, so the duration was 60 seconds

Study Arms (1)

stroke participants

Stroke participants with residual abnormal gait.

Other: pedal walking; Other: visual occlusion

Interventions

pedal walking OTHER

Pedal walking is a challenging walking task that can be used as a form of physical therapy for stroke participants.

stroke participants

visual occlusion OTHER

Walking with eyes-covered is a challenging walking task that can be used as a form of physical therapy for stroke participants.

stroke participants

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Stroke patients, including outpatients and inpatients.

You may qualify if:

• First-time occurrence of stroke confirmed by computed tomography or magnetic resonance imagingClinical diagnosis of stroke
• Disease duration of more than 14 days， less than 1 year
• Able to walk independently but with a lingering abnormal gait

You may not qualify if:

• Lesions accumulate in the brainstem
• Lesions accumulate in the cerebellum
• Impaired vision
• Severe cognitive impairment

Sponsors & Collaborators

• Nanjing Medical University: lead

Study Sites (2)

Geriatric Hospital of Nanjing Medical University, 269 Qingmen Street

Nanjing, Jiangsu, 210000, China

RECRUITING

Geriatric Hospital of Nanjing Medical University

Nanjing, Jiangsu, 210000, China

RECRUITING

Related Publications (3)

• Krakauer JW. Motor learning: its relevance to stroke recovery and neurorehabilitation. Curr Opin Neurol. 2006 Feb;19(1):84-90. doi: 10.1097/01.wco.0000200544.29915.cc.

  PMID: 16415682 BACKGROUND

• Fettrow T, Hupfeld K, Tays G, Clark DJ, Reuter-Lorenz PA, Seidler RD. Brain activity during walking in older adults: Implications for compensatory versus dysfunctional accounts. Neurobiol Aging. 2021 Sep;105:349-364. doi: 10.1016/j.neurobiolaging.2021.05.015. Epub 2021 May 31.

  PMID: 34182403 BACKGROUND

• Kulkarni A, Cui C, Rietdyk S, Ambike S. Humans prioritize walking efficiency or walking stability based on environmental risk. PLoS One. 2023 Apr 7;18(4):e0284278. doi: 10.1371/journal.pone.0284278. eCollection 2023.

  PMID: 37027387 BACKGROUND

Related Links

• This paper suggests that the rehabilitation of stroke patients may require more challenging tasks
• This paper suggests that the performance of complex walking tasks may involve top-down cortical control in the brain centers
• This paper shows that the central nervous system will actively respond to environmental changes and adjust to obtain stable motor output

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Xia Li Zhang, doctor

  Geriatric Hospital of Nanjing Medical University

  STUDY DIRECTOR

Central Study Contacts

Jing Zhao, master

CONTACT

+8618817892579; 18817892579@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Junior physiotherapist

Study Record Dates

• First Submitted: April 10, 2024
• First Posted: January 8, 2025
• Study Start: April 1, 2024
• Primary Completion: January 30, 2025
• Study Completion: February 28, 2025
• Last Updated: January 8, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: Six months after publication.
• Access Criteria: Request from the corresponding author by email.

Locations

CN (2)