Association of Sedentary Behaviour and Habitual Diet With Resting Fat Oxidation in Women With Overweight and Obesity

NCT06476444 | Completed DMC

• 1 other identifier: HU-SB-ZE-01
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to investigate the relationship between physical activity levels, dietary patterns with fat oxidation at rest in normal lean individuals and those with overweight and obese.

Conditions

Obesity; Healthy

Keywords

Metabolism; Health; Obesity; Diet; Physical Activity

Outcome Measures

Primary Outcomes (3)

• Resting fat oxidation

  In order to determine the relationship of dietary habits and habitual physical activity levels with resting fat oxidation in healthy overweight, obese and normal weight individuals, resting fat oxidation measurements will be performed with a indirect calorimetry (Cardio Pulmonary Exercise Testing, Quark CPET, Italy).All resting fat oxidation tests will be conducted in the same quiet room under a controlled ambient temperature (22-24 °C) and humidity (35-45%). Subjects will be instructed to arrive at the laboratory at 8 a.m. by car or by bus (avoiding any physical activity after waking up) and having fasted for at least 10-12 hours. In addition to this, they will be advised to avoid any moderate physical activity for the 24 h before the test day or any vigorous intensity exercise in the prior 48 h.

  From July 2024 to October 2024

• The relationship between habitual physical activity level and sedentary behaviour with resting fat oxidation

  Participants' habitual physical activity and sedentary behaviour will be measured with an accelerometer (Actigraph, USA) for 4 consecutive days to determine the relationship with resting fat oxidation.

  July 2024- October 2024

• Dietary pattern and fat oxidation

  In order to determine the relationship of macronutrient intake and food group consumption with resting fat oxidation, 4-day food consumption records will be obtained from the participants.

  July 2024- October 2024

Study Arms (2)

1. Women with Overweight and Obesity (25.0-34.9 BMI)

Healthy women with overweight and women without any chronic conditions other than obesity In this cross-sectional study, indirect calorimetry will be used to determine resting fat oxidation in these participants. Subsequently, the relationship between the resting fat oxidation data obtained with the habitual diet and physical activity status of these participants will be evaluated. Dietary patterns and physical activity will be assessed with 4 consecutive daily food consumption records and Actigraph GT3X+ devices, respectively.

2. Women with normal weight (18.5-24.9 BMI)

Healthy women with normal weight. In this cross-sectional study, indirect calorimetry will be used to determine resting fat oxidation in these participants. Thus, resting fat oxidation data of healthy women with normal weight and women with obesity/overweight will be compared. Subsequently, the relationship between the resting fat oxidation data obtained with the habitual diet and physical activity status of these participants will be evaluated. Dietary patterns and physical activity will be assessed with 4 consecutive daily food consumption records and Actigraph GT3X+ devices, respectively.

Eligibility Criteria

• Age: 25 Years - 50 Years
• Gender Eligibility Details: Women with overweight and obesity aged 25 to 50.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Sedentary women aged 25 to 50 with a body mass index range of 18.5-24.9 kg/m2 (normal weight; control group) and 25-34.9 kg/m2 (overweight and obese; research group) will be included in the study.

You may qualify if:

• Sedentary women aged 25-50 years with a body mass index range of 18.5-24.9 kg/m2 (normal weight) and 25-34.9 kg/m2 (overweight and obese) will be included in the study.

You may not qualify if:

• Smokers,
• Taking any medication or supplements that may affect metabolism,
• Dieting for more than 6 months,
• Pregnant or breastfeeding,
• Amenorrhoea,
• Individuals who meet the physical activity recommendations of the World Health Organisation (at least 150 min of moderate-to-vigorous exercise or at least 75 min of high-intensity exercise per week),
• Individuals with any chronic disease other than obesity will be excluded from the study.

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hacettepe University

Ankara, 06100, Turkey (Türkiye)

Location

Related Publications (2)

• Fletcher G, Eves FF, Glover EI, Robinson SL, Vernooij CA, Thompson JL, Wallis GA. Dietary intake is independently associated with the maximal capacity for fat oxidation during exercise. Am J Clin Nutr. 2017 Apr;105(4):864-872. doi: 10.3945/ajcn.116.133520. Epub 2017 Mar 1.

  PMID: 28251936 RESULT

• Jurado-Fasoli L, Amaro-Gahete FJ, Merchan-Ramirez E, Labayen I, Ruiz JR. Relationships between diet and basal fat oxidation and maximal fat oxidation during exercise in sedentary adults. Nutr Metab Cardiovasc Dis. 2021 Apr 9;31(4):1087-1101. doi: 10.1016/j.numecd.2020.11.021. Epub 2020 Dec 1.

  PMID: 33549436 RESULT

MeSH Terms

Conditions

Obesity; Motor Activity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Study Officials

• Necip Demirci, MSc.

  Hacettepe University

  STUDY CHAIR

• Muhammed Atakan, Ph.D

  Hacettepe University

  PRINCIPAL INVESTIGATOR

• Zeynep Ergun, BSc

  Hacettepe University

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dietitian

Study Record Dates

• First Submitted: June 21, 2024
• First Posted: June 26, 2024
• Study Start: September 1, 2023
• Primary Completion: May 15, 2024
• Study Completion: June 10, 2024
• Last Updated: July 1, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)