NCT06474572

Brief Summary

The study aims to compare the applied forces during intubation of a newborn manikin with direct and video laryngoscope at different heights of the resuscitation table. Furthermore, the success at the first attempt, the intubation time and participants' opinion on the procedures were investigated. This is an unblinded, randomized, controlled, crossover trial on the applied forces during intubation of a newborn manikin with direct and video laryngoscope at different heights of the resuscitation table.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
32

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jun 2024

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 28, 2024

Completed
4 days until next milestone

Study Start

First participant enrolled

June 1, 2024

Completed
Same day until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2024

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2024

Completed
24 days until next milestone

First Posted

Study publicly available on registry

June 25, 2024

Completed
Last Updated

June 25, 2024

Status Verified

June 1, 2024

Enrollment Period

Same day

First QC Date

May 28, 2024

Last Update Submit

June 19, 2024

Conditions

Keywords

NeonateIntubationDirect laryngoscopyVideo laryngoscopyForcesSimulation

Outcome Measures

Primary Outcomes (1)

  • Magnitide of applied forces (Newton)

    Magnitude of forces (measured in Newton) applied to the epiglottis and the palate of the neonatal manikin during the intubation

    3 minutes

Secondary Outcomes (3)

  • Percentage of participants achieving the intubation success at the first attempt

    30 seconds

  • Total time of intubation

    3 minutes

  • Participant's opinions about the procedure

    12 hours

Study Arms (4)

Direct laryngoscope and table at xiphoid level

ACTIVE COMPARATOR

Participants will be required to intubate the manikin with a direct laryngoscope and table at xiphoid level

Device: Direct laryngoscope and table at xiphoid level

Videolaryngoscope and table at xiphoid level

ACTIVE COMPARATOR

Participants will be required to intubate the manikin with a video laryngoscope and table at xiphoid level

Device: Videolaryngoscope and table at xiphoid level

Direct laryngoscope and table at umbilical level

ACTIVE COMPARATOR

Participants will be required to intubate the manikin with a direct laryngoscope and table at umbilical level

Device: Direct laryngoscope and table at umbilical level

Videolaryngoscope and table at umbilical level

EXPERIMENTAL

Participants will be required to intubate the manikin with a video laryngoscope and table at umbilical level

Device: Videolaryngoscope and table at umbilical level

Interventions

Participants will be required to intubate the manikin with a direct laryngoscope and table at xiphoid level

Direct laryngoscope and table at xiphoid level

Participants will be required to intubate the manikin with a video laryngoscope and table at xiphoid level

Videolaryngoscope and table at xiphoid level

Participants will be required to intubate the manikin with a direct laryngoscope and table at umbilical level

Direct laryngoscope and table at umbilical level

Participants will be required to intubate the manikin with a videolaryngoscope and table at umbilical level

Videolaryngoscope and table at umbilical level

Eligibility Criteria

Age25 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Level III NICU and PICU consultants, and pediatric residents

You may not qualify if:

  • Refusal to participate

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (6)

  • Evans P, Shults J, Weinberg DD, Napolitano N, Ades A, Johnston L, Levit O, Brei B, Krick J, Sawyer T, Glass K, Wile M, Hollenberg J, Rumpel J, Moussa A, Verreault A, Abou Mehrem A, Howlett A, McKanna J, Nishisaki A, Foglia EE. Intubation Competence During Neonatal Fellowship Training. Pediatrics. 2021 Jul;148(1):e2020036145. doi: 10.1542/peds.2020-036145. Epub 2021 Jun 25.

    PMID: 34172556BACKGROUND
  • Pouppirt NR, Nassar R, Napolitano N, Nawab U, Nishisaki A, Nadkarni V, Ades A, Foglia EE. Association Between Video Laryngoscopy and Adverse Tracheal Intubation-Associated Events in the Neonatal Intensive Care Unit. J Pediatr. 2018 Oct;201:281-284.e1. doi: 10.1016/j.jpeds.2018.05.046. Epub 2018 Jul 3.

    PMID: 29980290BACKGROUND
  • Geraghty LE, Dunne EA, Ni Chathasaigh CM, Vellinga A, Adams NC, O'Currain EM, McCarthy LK, O'Donnell CPF. Video versus Direct Laryngoscopy for Urgent Intubation of Newborn Infants. N Engl J Med. 2024 May 30;390(20):1885-1894. doi: 10.1056/NEJMoa2402785. Epub 2024 May 5.

    PMID: 38709215BACKGROUND
  • Xue FS, Li RP, Liu GP. Dynamic optimization of height relation between anaesthetist's chest and patient's face during tracheal intubation. Br J Anaesth. 2015 Feb;114(2):348-9. doi: 10.1093/bja/aeu479. No abstract available.

    PMID: 25596228BACKGROUND
  • Gordon JK, Bertram VE, Cavallin F, Parotto M, Cooper RM. Direct versus indirect laryngoscopy using a Macintosh video laryngoscope: a mannequin study comparing applied forces. Can J Anaesth. 2020 May;67(5):515-520. doi: 10.1007/s12630-020-01583-x. Epub 2020 Mar 9.

    PMID: 32152886BACKGROUND
  • Cavallin F, Pasquali G, Maglio S, Villani PE, Menciassi A, Tognarelli S, Trevisanuto D. Applied forces during neonatal intubation with direct and video laryngoscopy at different bed elevations: a randomized crossover manikin study. Eur J Pediatr. 2025 Nov 5;184(12):732. doi: 10.1007/s00431-025-06524-8.

MeSH Terms

Conditions

Infant, Newborn, Diseases

Condition Hierarchy (Ancestors)

Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Central Study Contacts

Daniele Trevisanuto, MD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

May 28, 2024

First Posted

June 25, 2024

Study Start

June 1, 2024

Primary Completion

June 1, 2024

Study Completion

June 1, 2024

Last Updated

June 25, 2024

Record last verified: 2024-06

Data Sharing

IPD Sharing
Will not share