Studying The Association Between Environmental Exposure to PFAS and Breast Cancer in Assiut Governorate- Egypt

NCT06457282 | Not Yet Recruiting

• 1 other identifier: Breast Cancer andPFAS exposure
• Study Type: observational
• Target: 42
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.Measuring serum level of PFAS in breast cancer female patients and healthy participants.
2. 2.Studying the correlation between serum level of PFAS and breast cancer risk through statistical modeling and analysis.
3. 3.Studying the magnitude of environmental exposure through measuring levels of PFAS in air and water sources of corresponding participants.

Conditions

Breast Cancer

Outcome Measures

Primary Outcomes (1)

• 1- Measuring serum level of PFAS in breast cancer female patients and healthy participants.

  Studying the correlation between serum level of PFAS and breast cancer risk through statistical modeling and analysis. Studying the magnitude of environmental exposure through measuring levels of PFAS in air and water sources of corresponding participants.

  2 yrs

Study Arms (2)

Case ( breast cancer patients)

Control ( Healthy people without breast cancer)

Eligibility Criteria

• Age: 18 Years - 65 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Female women age group between 18: 65 years. 2. Newly diagnosed cases. Who are diagnosed by ultrasonography and mammography and confirmed diagnosis after biopsy taken for histopathological examination

You may qualify if:

• Newly diagnosed cases. Who are diagnosed by ultrasonography and mammography and confirmed diagnosis after biopsy taken for histopathological examination.

You may not qualify if:

• \. Patients who underwent neoadjuvant chemotherapy prior to their surgery will be excluded from the study.
• To eliminate confounding factors, breast cancer patients with comorbidities and chronic diseases such as uncontrolled diabetes mellitus or other endocrine disorders, poorly controlled hypertension, acute coronary syndrome, congestive heart failure, chronic kidney disease and chronic liver disease will be excluded.
• Women with biopsy-proven benign breast disease should be excluded
• Patients who have other malignancies are excluded
• \. patients with family history of breast cancer will be excluded. 7. Patients refuse to continue the study

Sponsors & Collaborators

• Assiut University: lead

Related Publications (4)

• Tsai MS, Chang SH, Kuo WH, Kuo CH, Li SY, Wang MY, Chang DY, Lu YS, Huang CS, Cheng AL, Lin CH, Chen PC. A case-control study of perfluoroalkyl substances and the risk of breast cancer in Taiwanese women. Environ Int. 2020 Sep;142:105850. doi: 10.1016/j.envint.2020.105850. Epub 2020 Jun 21.

  PMID: 32580117 BACKGROUND

• Itoh H, Harada KH, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, Kusama R, Yokoyama K, Zhu J, Harada Sassa M, Tsugane S, Iwasaki M. Serum perfluoroalkyl substances and breast cancer risk in Japanese women: A case-control study. Sci Total Environ. 2021 Dec 15;800:149316. doi: 10.1016/j.scitotenv.2021.149316. Epub 2021 Jul 29.

  PMID: 34392213 BACKGROUND

• Pierozan P, Cattani D, Karlsson O. Tumorigenic activity of alternative per- and polyfluoroalkyl substances (PFAS): Mechanistic in vitro studies. Sci Total Environ. 2022 Feb 20;808:151945. doi: 10.1016/j.scitotenv.2021.151945. Epub 2021 Nov 27.

  PMID: 34843762 BACKGROUND

• Velarde MC, Chan AFO, Sajo MEJV, Zakharevich I, Melamed J, Uy GLB, Teves JMY, Corachea AJM, Valparaiso AP, Macalindong SS, Cabaluna ND, Dofitas RB, Giudice LC, Gerona RR. Elevated levels of perfluoroalkyl substances in breast cancer patients within the Greater Manila Area. Chemosphere. 2022 Jan;286(Pt 1):131545. doi: 10.1016/j.chemosphere.2021.131545. Epub 2021 Jul 12.

  PMID: 34293563 BACKGROUND

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Central Study Contacts

Jacklin Farouk

CONTACT

01207507866; gigifarouk22@gmail.com

Dr. Randa Hussein Abdelhady, Professor

CONTACT

01006723004

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Demonstrator

Study Record Dates

• First Submitted: June 8, 2024
• First Posted: June 13, 2024
• Study Start: July 1, 2024
• Primary Completion: July 1, 2025
• Study Completion: August 1, 2025
• Last Updated: June 13, 2024

Record last verified: 2024-05