Circular RNA and Chemerin in Breast Cancer Patient

NCT05771337 | Unknown

• 1 other identifier: biomarkers in breast cancer
• Study Type: observational
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aimed to evaluate the role of serum chemerin as a biomarker of breast cancer. and To investigate the diagnostic value of hsa\_circ\_0001785 (Circ-ELP3) and hsa\_circ\_100219 (Circ-FAF1) in serum samples of breast cancer patients to find out whether these circRNAs can utilize as a diagnostic and prognostic biomarker for human breast cancer assessment and make Correlation between serum chemerin levels , serum Circ-FAF1 , serum CircELP3 and classical tumor markers (CEA + CA15-3). andTo elucidate if there is a difference between metastatic and non-metastatic cases as regard serum chemerin levels, serum Circ-FAF1 or Circ-ELP3.

Conditions

Breast Cancer

Outcome Measures

Primary Outcomes (1)

• measure chemerin and Circular RNA in breast cancer patients

  To elucidate if there is a difference between metastatic and non-metastatic cases as regard serum chemerin levels, serum Circ-FAF1 or Circ-ELP3.

  2 years

Study Arms (2)

breast cancer leasion

Diagnostic Test: blood sample

benign breast lesion

Diagnostic Test: blood sample

Interventions

blood sample DIAGNOSTIC_TEST

blood sample

benign breast lesion; breast cancer leasion

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

female with breast cancer

You may qualify if:

• histopathological diagnosis of breast cancer

You may not qualify if:

• history of other types of cancers
• history of HIV
• history of any therapeutic interventions in form of chemo or hormonal therapy before specimen collection

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Song Y, Zhu X, Lin Z, Luo L, Wen D. The potential value of serum chemerin in patients with breast cancer. Sci Rep. 2021 Mar 22;11(1):6564. doi: 10.1038/s41598-021-85986-w.

  PMID: 33753802 BACKGROUND

• Omid-Shafaat R, Moayeri H, Rahimi K, Menbari MN, Vahabzadeh Z, Hakhamaneshi MS, Nouri B, Ghaderi B, Abdi M. Serum Circ-FAF1/Circ-ELP3: A novel potential biomarker for breast cancer diagnosis. J Clin Lab Anal. 2021 Nov;35(11):e24008. doi: 10.1002/jcla.24008. Epub 2021 Sep 21.

  PMID: 34545638 BACKGROUND

MeSH Terms

Conditions

Breast Neoplasms

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Central Study Contacts

sandy nashat sorial

CONTACT

01200693648; sandybsbsa@yahoo.com

abdelhaleem ali abdelhaleem

CONTACT

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: demonstrator in biochemestry departement

Study Record Dates

• First Submitted: March 5, 2023
• First Posted: March 16, 2023
• Study Start: October 1, 2023
• Primary Completion: October 1, 2025
• Study Completion: December 1, 2025
• Last Updated: March 16, 2023

Record last verified: 2023-03