Using of Costimulatory and co Inhibatory Immune Checkpoints as Diagnostic and Prognostic in Breast Cancer

NCT06169007 | Unknown

• 1 other identifier: Immune checkpoints in cancer
• Study Type: observational
• Target: 84
• Locations: 0 countries
• Sites: N/A

Brief Summary

Checkpoint proteins regulate the immune system; breast cancer cells exploit the up-regulation or down-regulation of these proteins to evade anti-tumour immune responses . It is now well recognized that advanced metastatic BC and early disease are associated with both localized and systemic immune dysfunction .in this study levels of soluble immune checkpoint molecules sTIM3 and sCD40 will be measured and compared with tissue form ,then follow up to patients' prognosis and the relation to markers levels.

Conditions

Breast Cancer

Keywords

breast cancer and sCD40 and sTIM-3

Outcome Measures

Primary Outcomes (1)

• evaluate the levels of sTIM-3 and sCD40 in breast cancer patients in different stages and follow up their role in disease prognosis compared with healthy controls. Results will be compared with the previous studies.

  study will take about 12months to be completed

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Female patients with breast cancer and healthy females as controls

You may qualify if:

• Female patients with breast cancer aged \> 18 years attending the Medical Oncology department of South Egypt Cancer Institute

You may not qualify if:

• Patients on chemotherapy
• A history of any other malignancy
• known (HIV) and/or hepatitis B or hepatitis C viruses,
• pregnancy or breast feeding
• patients or controls that refuse to be a part of the study.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Breast Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• Lamiaa Fadel, lecturer

  Assiut University

  STUDY DIRECTOR

Central Study Contacts

Asmaa Mohammed, demostrator

CONTACT

01140266310; asmamohammed10101995@aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: December 5, 2023
• First Posted: December 13, 2023
• Study Start: May 1, 2024
• Primary Completion: October 1, 2025
• Study Completion: December 1, 2025
• Last Updated: December 20, 2023

Record last verified: 2023-12