The Barts Charity Children's Environmental Health Clinic

NCT06447974 | Recruiting

• 1 other identifier: 325076
• Study Type: interventional
• Target: 200
• Locations: 1 country
• Sites: 2

Brief Summary

The study will be based from a newly formed NHS service, the children's environmental health service. Participants will be children with a known chronic respiratory condition. Participants will undergo personal environmental exposure monitoring as well as home environmental assessments, before personalised exposure reports will be provided including a summary of their exposure and advising mitigation strategies based on exposure patterns and behaviours. The monitoring will be repeated after introduction of mitigation strategies. This will allow a comparison of the effectiveness of each method of mitigation.

Conditions

Environmental Exposure; Health Behavior; Asthma in Children; Environmental Illness

Keywords

asthma; Air pollution; environmental; Environmental health clinic

Outcome Measures

Primary Outcomes (1)

• How effective is a specialist NHS environmental health clinic in reducing exposure to environmental contaminants in children with chronic respiratory disease, and what is the change in health outcomes.

  Measurement of the concentrations of common air contaminants (PM1, PM2.5, PM5, PM10, VOCs), the GPs location of areas of high concentration and the behaviours of the individual at times of high and low exposure. For each participant, the social and behavioural factors affecting their exposure will be measured using the environmental health questionnaire (type of accommodation, proximity of school and home to main roads, type of cooking fuel and sprays used in the home, presence or absence of damp or mould, and mode and duration of school commute.

  3 years

Secondary Outcomes (8)

• What is the environmental exposure of children attending the environmental health clinic?

  3 years

• Are clinical tests such as salivary cotinine, exhaled carbon monoxide or blood eosinophils useful in screening for children who have a high environmental exposure to pollutants?

  3 years

• At which locations and times of day are children exposed to the most air pollution?

  3 years

• Does exposure to indoor and outdoor air pollution follow a repeated pattern each day?

  3 years

• Which factors affect the levels of environmental exposure to pollutants?

  3 years

Study Arms (1)

Pre and post intervention

OTHER

A single arm for measurement both pre and post introduction of intervention

Behavioral: Exposure mitigations

Interventions

Exposure mitigations BEHAVIORAL

Behavioural interventions with an aim to reduce exposure by targeting occurrences of high exposure

Pre and post intervention

Eligibility Criteria

• Age: 4 Years - 17 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Parent/Guardian able to provide written informed consent
• Referral made by paediatric asthma team
• Child aged 4-17 years at the time of consent to study
• A diagnosis of a chronic respiratory condition (diagnosis by a medical professional)
• Contactable for regular follow up by the research team
• Reasonable level of English language
• Ability to engage with technology and devices used in the study

You may not qualify if:

• Inability to use the tools and devices in the research study
• Inability to visit the hospital for the initial hospital visit
• Inability to allow home environmental assessment

Sponsors & Collaborators

• Queen Mary University of London: lead
• Barts & The London NHS Trust: collaborator

Study Sites (2)

Queen Mary University of London

London, E1 2AT, United Kingdom

ENROLLING BY INVITATION

The Royal London Hospital

London, E1, United Kingdom

RECRUITING

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• Personal interventions and risk communication on air pollution. Geneva: World Health Organization ; 2020. Licence : CC BY-NC-SA 3.0 IGO.

  BACKGROUND

MeSH Terms

Conditions

Health Behavior; Environmental Illness; Asthma

Condition Hierarchy (Ancestors)

Behavior; Hypersensitivity; Immune System Diseases; Disorders of Environmental Origin; Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate

Study Officials

• Charles S Moorcroft, MBChB

  Queen Mary University of London

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Charles S Moorcroft

CONTACT

07808061892; c.moorcroft@qmul.ac.uk

Abigail Whitehouse

CONTACT

a.whitehouse@qmul.ac.uk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: no masking
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Participants undergo personal exposure monitoring before and after the introduction of mitigation strategies.

Study Record Dates

• First Submitted: April 24, 2023
• First Posted: June 7, 2024
• Study Start: July 24, 2025
• Primary Completion (Estimated): June 1, 2027
• Study Completion (Estimated): June 1, 2027
• Last Updated: August 12, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

GB (2)