Use of Air Purifiers to Improve Respiratory Health in Children

NCT05817357 | Completed

• 1 other identifier: UoL001754
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this pilot study is to investigate if installing an air purifier in the homes of children and young people with asthma improves their asthma outcomes. The main questions it aims to answer are:

• Does installing an air purifier in the homes of children and young people with asthma improve their asthma outcomes
• Is the use of an air purifier in the home acceptable to children and young people and their families? Children and young people with asthma attending our clinic will be selected at random to be invited to take part. For those that take part, an air purifier (Rensair Ltd. - Rensair Compact) will be installed in their home for a one-year period. Data will be collected on numbers of asthma attacks, rescue oral steroids, quality of life, symptoms, lung function at the beginning and at three-monthly intervals throughout the study period. The acceptability to children and young people and their families taking part in this study of using an air purifier in their home will also be assessed.

Conditions

Asthma in Children

Outcome Measures

Primary Outcomes (12)

• Number of asthma exacerbations (asthma attacks)

  Asthma attacks and unscheduled healthcare visits due to acute asthma (including ED attendance, admission, GP/primary care attendance) - assessed by questionnaire and hospital-recorded attendances/admissions

  12 months

• Number of rescue oral steroid courses

  Number of rescue oral steroid courses - assessed by questionnaire and prescription data

  12 months

• Quality of life - mini paediatric asthma quality of life questionnaire score

  Quality of life using mini paediatric asthma quality of life questionnaire - the higher the score the better the quality of life

  12 months

• Asthma control test score

  Asthma control test (ACT) or child asthma control test score (cACT) - depending on age of participant - the higher the score the better the asthma control

  12 months

• Amount of asthma reliever medication use per week

  Amount of use of asthma reliever medication use over a one week period (assessed as a categorical value)

  12 months

• Number of school days absent due to asthma

  Number of school days missed due to asthma - assessed by questionnaire

  12 months

• Number of parent/carer work days missed due to their child's asthma

  Number of work days missed due to child's asthma - assessed by questionnaire

  12 months

• Forced expired volume in one second (FEV1)

  Spirometry measurements using ERS/ATS criteria and Global Lung Initiative Reference z-score

  12 months

• Forced vital capacity (FVC)

  Spirometry measurements using ERS/ATS criteria and Global Lung Initiative Reference z-score

  12 months

• FEV1:FVC

  Spirometry measurements using ERS/ATS criteria and Global Lung Initiative Reference z-score

  12 months

• Measurement of fraction of exhaled nitric oxide (FeNO)

  Fraction of exhaled nitric oxide measurements

  12 months

• Acceptability to children and families participating of using an air purifier in their home

  Acceptability to children and young people and their families taking part in the study in terms of use of air purifier in their homes - assessed by questionnaire

  12 months

Study Arms (1)

Installation of air purifier (Rensair Ltd - Rensair Compact)

EXPERIMENTAL

Rensair Compact air purifier unit will be installed in the homes of all children/young people participating in this study for a period of one-year.

Device: Rensair Compact air purifier unit

Interventions

Rensair Compact air purifier unit DEVICE

Installation of Rensair Compact air purifier (Rensair Ltd.) in the homes of children/young people participating in this study

Installation of air purifier (Rensair Ltd - Rensair Compact)

Eligibility Criteria

• Age: 5 Years - 15 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Aged 5 to 15 years old
• Attend the asthma clinic in our hospital
• Have a confirmed physician-diagnosis of asthma from the asthma clinic
• Live in mainland England (this is due to delivery of the air purification units and also associated maintenance of them)

Sponsors & Collaborators

• University of Liverpool: lead

Study Sites (1)

Alder Hey Children's Hospital

Liverpool, Merseyside, L12 2AP, United Kingdom

Location

Study Officials

• karl A Holden

  University of Liverpool

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 22, 2023
• First Posted: April 18, 2023
• Study Start: May 2, 2023
• Primary Completion: August 30, 2024
• Study Completion: August 30, 2024
• Last Updated: December 19, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)