Resistance Exercise Plus Vinegar Ingestion on Biomarkers in Healthy Adults

NCT06437405 | Completed

• 1 other identifier: STUDY00019774
• Study Type: interventional
• Target: 29
• Locations: 1 country
• Sites: 1

Brief Summary

Given its capacity to stimulate exercise-induced neuroplasticity at lower doses compared to aerobic exercise, resistance exercise has become the top-recommended rehabilitation approach for individuals with neurocognitive impairments. Despite a large body of evidence supporting its application in the context of cognition, little work has been done to investigate the role of resistance exercise in modifying the structure and function of the microbiota-gut-brain axis. Likewise, despite a general understanding of the benefits of short chain fatty acids such as acetate for the gut-brain axis, the impact of exogenous acetic acid has not been sufficiently examined in the context of the intestinal barrier. While self-reported mood disturbance responds favorably to vinegar ingestion, it is currently unknown if these effects are also associated with changes in intestinal permeability.

Conditions

LPS; Mood Disorders; Cognitive Change

Keywords

vinegar; resistance training; strength; depression

Outcome Measures

Primary Outcomes (3)

• Lipopolysaccharide

  measured indirectly via LPS binding protein

  12 weeks

• Depression

  measured via Profile of Mood States (POMS) questionnaire

  12 weeks

• Cognitive change

  measured using Trail Making Test

  12 weeks

Study Arms (2)

Liquid vinegar

EXPERIMENTAL

2 tablespoons of liquid apple cider vinegar (5% acidity) diluted in one cup of water twice daily with meals providing 1.5g acetic acid.

Dietary Supplement: Vinegar liquid

Vinegar pill

PLACEBO COMPARATOR

one apple cider vinegar tablet (0.022g acetic acid) daily.

Dietary Supplement: vinegar pill

Interventions

Vinegar liquid DIETARY_SUPPLEMENT

one pill daily

Also known as: Vinegar pill

Liquid vinegar

vinegar pill DIETARY_SUPPLEMENT

One pill daily

Vinegar pill

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• premenopausal (for those assigned female at birth)
• willing and able to participate in moderate to vigorous exercise as determined by the ACSM Health/Fitness Facility Preparticipation Screening Questionnaire
• sedentary (defined as a score \<14 on the Godin-Shepard Leisure Time Physical Activity Questionnaire (GSLTQ))
• equipped with access to a complete gym
• available for all lab visits (at weeks 0, 3, 9, and 15)

You may not qualify if:

• antibiotic use within the past three months
• prebiotic, probiotic, or high-dose antioxidant supplementation within the past month
• regular engagement in moderate to vigorous exercise
• following a vegetarian diet
• presence of any medical/psychiatric disease
• presence of any gastrointestinal disorder such as irritable bowel syndrome, inflammatory bowel disease, Crohn's disease, diverticulitis/diverticulosis, etc.
• actively pregnant or breastfeeding

Sponsors & Collaborators

• Arizona State University: lead

Study Sites (1)

850 PBC

Phoenix, Arizona, 85004, United States

Location

MeSH Terms

Conditions

Mood Disorders; Depression

Interventions

Acetic Acid

Condition Hierarchy (Ancestors)

Mental Disorders; Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Acetates; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Fatty Acids, Volatile; Fatty Acids; Lipids

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: participants will be randomly assigned to the liquid vinegar group or the vinegar pill group (control)
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor and Associate Dean

Model Details: 12-week randomized controlled trial preceded by a 3-week control period

Study Record Dates

• First Submitted: May 26, 2024
• First Posted: May 31, 2024
• Study Start: May 22, 2024
• Primary Completion: February 15, 2025
• Study Completion: February 15, 2025
• Last Updated: April 9, 2025

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)