Daily Vinegar Ingestion and 24-Hour Blood Glucose Control

NCT06319443 | Completed

• 1 other identifier: STUDY00019235
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

When linking dietary interventions and blood glucose management, much of the existing research - particularly studies exploring the effects of vinegar - has relied on discrete readings from the conventional testing methods: blood samples or glucometers. These methods lack the capacity to provide insights into blood glucose dynamics 24/7. Recognizing this gap, the current study aims to utilize continuous glucose monitoring to examine the impact of daily vinegar ingestion on glucose variability in adults identified as glucose intolerant.

Conditions

Glucose Intolerance

Keywords

glucose; continuous glucose monitoring; vinegar

Outcome Measures

Primary Outcomes (2)

• Average glucose

  The average blood glucose concentration for each 4-day period

  Four days

• Glucose: time in range

  The average time over 4 days that blood glucose falls in the reference range

  Four days

Study Arms (2)

Liquid vinegar

EXPERIMENTAL

Liquid vinegar (6% acidity) consumed at a dosage of 2 tablespoons (diluted in water and consumed at mealtime) twice daily (4 tablespoons total per day).

Dietary Supplement: Liquid vinegar

Vinegar pill

PLACEBO COMPARATOR

One pill consumed daily in the morning.

Dietary Supplement: vinegar pill

Interventions

Liquid vinegar DIETARY_SUPPLEMENT

3.5 g acetic acid

Liquid vinegar

vinegar pill DIETARY_SUPPLEMENT

0.022 g acetic acid

Vinegar pill

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• glucose intolerance (defined as one of the following: fasting glucose \>99 mg/dl; diagnosis of prediabetes or diabetes; history of gestational diabetes)
• years of age or older
• sedentary or moderately active (defined as a score ≤ 24 on the Godin-Shepard Leisure Time Physical Activity Questionnaire)

You may not qualify if:

• currently adhering to a non-typical diet that would impact carbohydrate intake (including weight loss diets)
• medication/drug use that has not been consistent for the previous 3 months or will be discontinued during the trial
• any acute illness
• regular smokers, pregnant or lactating women, or individuals taking insulin
• Unwilling to tolerate vinegar ingestion

Sponsors & Collaborators

• Arizona State University: lead

Study Sites (1)

850 PBC

Phoenix, Arizona, 85004, United States

Location

MeSH Terms

Conditions

Glucose Intolerance

Interventions

Acetic Acid

Condition Hierarchy (Ancestors)

Hyperglycemia; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Acetates; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Fatty Acids, Volatile; Fatty Acids; Lipids

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Liquid and pill vinegar will be the treatments. The pill is the 'control' as the level of acetic acid is below the amount needed for an antiglycemic effect (a fact not realized by the participant).
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor and Associate Dean

Model Details: This is a 9-day trial. Participants will be fitted with a continuous glucose monitor and follow their typical diet and activity patterns. Participants will be randomized to ingest 2 tablespoons of vinegar twice daily (diluted in water) or a vinegar pill for the first 4 days on the trial. On day 5 of the trial participants will consume the alternate treatment for trial days 5-8. Dietary intake will be recorded daily using a fitness app. Physical activity will be assessed at baseline and on study day 4 and 8. On day 9, participants will return to the test site for device removal.

Study Record Dates

• First Submitted: March 13, 2024
• First Posted: March 20, 2024
• Study Start: March 26, 2024
• Primary Completion: December 15, 2024
• Study Completion: July 15, 2025
• Last Updated: August 17, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)