Barts Endocarditis Research Registry
1 other identifier
observational
1,000
1 country
1
Brief Summary
The Barts Endocarditis Research Registry is being set up to give a unique opportunity to assess the characteristics of Infective Endocarditis (IE) in our population cohort, the current use of imaging techniques, as well as the implementation of the ESC guidelines and its consequence in terms of prognosis. All this will help improve the diagnosis and management of IE. The registry will also form the core of all our subsequent work, including interventional studies. The endocarditis research registry is to record the epidemiological, demographic, microbiological, surgical and outcome data in our cohort of endocarditis patients. This work will underpin all future work in endocarditis by clearly defining our patient cohort and the outcomes from treatment. We have a series of studies planned that we believe will influence the management of endocarditis (we are working up proposals for genomic and therapeutic trials that will subsequently be presented for ethical and hospital approval). The registry will be generic to all our planned studies, and will allow us to capture data to assess treatment effectiveness
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2019
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 24, 2019
CompletedFirst Submitted
Initial submission to the registry
May 23, 2024
CompletedFirst Posted
Study publicly available on registry
May 30, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 24, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
April 30, 2029
July 15, 2025
July 1, 2025
10 years
May 23, 2024
July 10, 2025
Conditions
Outcome Measures
Primary Outcomes (4)
To define current mortality rates for patients treated for endocarditis at Barts Heart Centre
The primary goal of the endocarditis registry is to record the epidemiological, demographic, microbiological, surgical and outcome data in our cohort of endocarditis patients. This work will underpin all future work in endocarditis by clearly defining our patient cohort and the outcomes from treatment.
10 years
To define current morbidity rates for patients treated for endocarditis at Barts Heart Centre
The primary goal of the endocarditis registry is to record the epidemiological, demographic, microbiological, surgical and outcome data in our cohort of endocarditis patients. This work will underpin all future work in endocarditis by clearly defining our patient cohort and the outcomes from treatment.
10 years
To define current rates of reinfection for patients treated for endocarditis at Barts Heart Centre
The primary goal of the endocarditis registry is to record the epidemiological, demographic, microbiological, surgical and outcome data in our cohort of endocarditis patients. This work will underpin all future work in endocarditis by clearly defining our patient cohort and the outcomes from treatment.
10 years
To define current rates of relapse for patients treated for endocarditis at Barts Heart Centre
The primary goal of the endocarditis registry is to record the epidemiological, demographic, microbiological, surgical and outcome data in our cohort of endocarditis patients. This work will underpin all future work in endocarditis by clearly defining our patient cohort and the outcomes from treatment.
10 years
Secondary Outcomes (4)
To collect data regarding infecting organism, valve appearances and pathological markers and investigate their relationship to mortality, morbidity, reinfection and relapse rates
10 years
To collect data regarding infecting organism and investigate its relationship to mortality, morbidity, reinfection and relapse rates
10 years
To collect data regarding valve appearance and investigate its relationship to mortality, morbidity, reinfection and relapse rates
10 years
To collect data regarding pathological markers and investigate its relationship to mortality, morbidity, reinfection and relapse rates
10 years
Interventions
This is registry for Infective Endocarditis
Eligibility Criteria
There are approximately 150 cases of endocarditis each year treated within the trust and recruitment is expected to be rapid
You may qualify if:
- Patients aged 16 and over (Patients under 16 years of age are not admitted to Barts Heart Centre)
- Patients admitted to Barts Heart Centre with confirmed Endocarditis (see above)
- Patients attending outpatients with confirmed/suspected Endocarditis
- Patients with possible IE who complete treatment for endocarditis
- Patients with cardiac device related Endocarditis
- Patients with the ability to provide informed consent
You may not qualify if:
- Patients with pacemaker pocket infection with no evidence of pacemaker lead or valve infection
- Patients who refuse consent to be included in the research database
- Patients with "rejected" endocarditis
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
St Bartholomews Hospital
London, United Kingdom
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Simon Woldman, MSc
St Bartholomews Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 23, 2024
First Posted
May 30, 2024
Study Start
April 24, 2019
Primary Completion (Estimated)
April 24, 2029
Study Completion (Estimated)
April 30, 2029
Last Updated
July 15, 2025
Record last verified: 2025-07