A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Program to Evaluate the Efficacy and Safety of Tulisokibart in Participants With Moderately to Severely Active Crohn's Disease
5 other identifiers
interventional
1,200
45 countries
487
Brief Summary
The purpose of this protocol is to evaluate the efficacy and safety of tulisokibart in participants with moderately to severely active Crohn's disease. Study 1's primary hypotheses are that at least 1 tulisokibart dose level is superior to placebo in the proportion of participants achieving clinical remission per Crohn's Disease Activity Index score (\<150, US/FDA) or per stool frequency and abdominal pain score (EU/EMA) and in the proportion of participants achieving endoscopic response at Week 52 (US/FDA and EU/EMA), and that at least 1 tulisokibart dose level is superior to placebo in the proportion of participants achieving clinical remission per Crohn's Disease Activity Index score (\<150, US/FDA) or per stool frequency and abdominal pain score (EU/EMA) and in the proportion of participants achieving endoscopic response at Week 12 (US/FDA and EU/EMA). Study 2's primary hypothesis is that at least 1 tulisokibart dose level is superior to placebo in the proportion of participants achieving clinical remission per Crohn's Disease Activity Index score (\<150, US/FDA) or stool frequency and abdominal pain score (EU/EMA) and in the proportion of participants achieving endoscopic response at Week 12 (US/FDA and EU/EMA).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Jun 2024
Longer than P75 for phase_3
487 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 21, 2024
CompletedFirst Posted
Study publicly available on registry
May 28, 2024
CompletedStudy Start
First participant enrolled
June 5, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 30, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
November 12, 2029
June 12, 2026
June 1, 2026
4.4 years
May 21, 2024
June 11, 2026
Conditions
Outcome Measures
Primary Outcomes (9)
Study 1 [US/FDA Only]: Percentage of Participants Achieving Clinical Remission per Crohn's Disease Activity Index (CDAI) Score at Week 52
The percentage of participants achieving clinical remission, as defined by CDAI score \<150 for study 1 will be presented.
Week 52
Study 1 [EU/EMA Only]: Percentage of Participants Achieving Clinical Remission per Stool Frequency and Abdominal Pain Score at Week 52
The percentage of participants achieving clinical remission per stool frequency/abdominal pain score (SF/APS), as defined by average daily SF ≤2.8 and average daily APS ≤1.0 and both not greater than baseline for study 1 will be presented.
Week 52
Study 1: Percentage of Participants Achieving Endoscopic Response at Week 52
The percentage of participants achieving endoscopic response, as defined by a ≥50% decrease in Simplified endoscopic score for Crohn's disease (SES-CD) from baseline for study 1 will be presented.
Week 52
Study 1: Percentage of Participants Achieving Clinical Remission per CDAI Score at Week 12
The percentage of participants achieving clinical remission, as defined by CDAI score \<150 for study 1 will be presented.
Week 12
Study 1: Percentage of Participants Achieving Clinical Remission per Stool Frequency and Abdominal Pain Score at Week 12
The percentage of participants achieving clinical remission per SF/APS, as defined by average daily SF ≤2.8 and average daily APS ≤1.0 and both not greater than baseline for study 1 will be presented.
Week 12
Study 1: Percentage of Participants Achieving Endoscopic Response at Week 12
The percentage of participants achieving endoscopic response, as defined by a ≥50% decrease in SES-CD from baseline for study 1 will be presented.
Week 12
Study 2 [US/FDA Only]: Percentage of Participants Achieving Clinical Remission per CDAI Score at Week 12
The percentage of participants achieving clinical remission, as defined by CDAI score \<150 for study 2 will be presented.
Week 12
Study 2 [EU/EMA Only]: Percentage of Participants Achieving Clinical Remission per Stool Frequency and Abdominal Pain Score at Week 12
The percentage of participants achieving clinical remission per SF/APS, as defined by average daily SF ≤2.8 and average daily APS ≤1.0 and both not greater than baseline for study 2 will be presented.
Week 12
Study 2: Percentage of Participants Achieving Endoscopic Response at Week 12
The percentage of participants achieving endoscopic response, as defined by a ≥50% decrease in SES-CD from baseline for study 2 will be presented.
Week 12
Secondary Outcomes (31)
Study 1: Percentage of Participants Who Experienced an Adverse Event (AE)
Up to approximately 52 weeks
Study 1: Percentage of Participants who Discontinue Study Intervention due to an AE
Up to approximately 52 weeks
Study 1 [US/FDA Only]: Percentage of Participants Achieving Clinical Remission per Stool Frequency and Abdominal Pain Score at Week 12
Week 12
Study 1 [EU/EMA Only]: Percentage of Participants Achieving Clinical Remission per CDAI Score at Week 12
Week 12
Study 1: Percentage of Participants with Decrease of ≥100 Points in CDAI Score from Baseline to Week 12
Week 12
- +26 more secondary outcomes
Study Arms (11)
Study 1: High Dose Induction, High Dose Maintenance
EXPERIMENTALParticipants receive high dose intravenous (IV) tulisokibart, followed by a high dose subcutaneous (SC) tulisokibart regimen.
Study 1: High Dose Induction, Low Dose Maintenance
EXPERIMENTALParticipants receive high dose IV tulisokibart, followed by a low dose SC tulisokibart regimen.
Study 1: Low Dose Induction, Low Dose Maintenance
EXPERIMENTALParticipants receive low dose IV tulisokibart, followed by a low dose SC tulisokibart regimen.
Study 1: Placebo
PLACEBO COMPARATORParticipants receive IV placebo, followed by an SC placebo regimen.
Study 1: High Dose Extension
EXPERIMENTALParticipants receive a high dose SC tulisokibart regimen. Participants may continue in this arm after completing participation in their original arm, if they meet protocol-specific prerequisites.
Study 1: Low Dose Extension
EXPERIMENTALParticipants receive a low dose SC tulisokibart and placebo regimen. Participants may continue in this arm after completing participation in their original arm, if they meet protocol-specific prerequisites.
Study 2: High Dose Induction
EXPERIMENTALParticipants receive high dose IV tulisokibart.
Study 2: Low Dose Induction
EXPERIMENTALParticipants receive low dose IV tulisokibart.
Study 2: Placebo
PLACEBO COMPARATORParticipants receive IV placebo.
Study 2: High Dose Extension
EXPERIMENTALParticipants receive a high dose SC tulisokibart regimen. Participants may continue in this arm only after completing participation in their original arm, if they meet protocol-specific prerequisites.
Study 2: Low Dose Extension
EXPERIMENTALParticipants receive a low dose SC tulisokibart regimen. Participants may continue in this arm only after completing participation in their original arm, if they meet protocol-specific prerequisites.
Interventions
Humanized monoclonal antibody that binds human TL1A, administered subcutaneously
Humanized monoclonal antibody that binds human tumor necrosis factor-like cytokine 1A (TL1A), administered intravenously
Placebo matching SC tulisokibart
Eligibility Criteria
You may not qualify if:
- Has had a diagnosis of CD at least 3 months before study.
- Has moderately to severely active CD.
- Demonstrated inadequate response, loss of response, or intolerance to one or more of the following categories of drugs: oral locally acting steroids, systemic steroids, immunomodulators, biologic and/or small molecule advanced therapies.
- Adolescent participants ≥16 and \<18 years of age can participate if approved by the country or regulatory/health authority.
- Has diagnosis of ulcerative colitis (UC) or indeterminate colitis.
- Has CD isolated to the stomach, duodenum, jejunum, or perianal region, without colonic and/or ileal involvement.
- Currently has any of the following complications of CD: suspected or diagnosed with intra-abdominal or perianal abscess, known symptomatic stricture or colonic stenosis not passable in endoscopy, fulminant colitis, toxic megacolon, or any other manifestation that might require surgery while enrolled in the study.
- Has current stoma or need for colostomy or ileostomy.
- Is missing \>2 segments of the following 5 segments: terminal ileum, right colon, transverse colon, sigmoid and left colon, and rectum.
- Has been diagnosed with short gut or short bowel syndrome, or any other uncontrolled chronic diarrhea besides Crohn's disease.
- Has surgical bowel resection within 3 months of study.
- Has prior or current gastrointestinal dysplasia.
- Has chronic infection requiring ongoing antimicrobial treatment.
- Has a history of cancer (except fully treated non-melanoma skin cell cancers or cervical carcinoma in situ after complete surgical removal) and is disease free for \<5 years.
- Is infected with Hepatitis B virus (HBV), Hepatitis C virus (HCV), or human immunodeficiency virus (HIV).
- +3 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (499)
Digestive Health Specialists ( Site 5064)
Dothan, Alabama, 36301, United States
Arizona Arthritis & Rheumatology Research, PC ( Site 5094)
Phoenix, Arizona, 85032, United States
GI Alliance - Sun City ( Site 5118)
Sun City, Arizona, 85351, United States
University of Arizona Clinical and Translational Sciences Research Center ( Site 5111)
Tucson, Arizona, 85724, United States
University of Arkansas for Medical Sciences ( Site 5147)
Little Rock, Arkansas, 72205, United States
Clinnova Research ( Site 5110)
Anaheim, California, 92805, United States
Southern California Research Center ( Site 5044)
Coronado, California, 92118, United States
Om Research LLC ( Site 5038)
Lancaster, California, 93534, United States
Cedars Sinai Medical Center ( Site 5080)
Los Angeles, California, 90048, United States
UCLA Clinical & Translational Research Center (CTRC) ( Site 5116)
Los Angeles, California, 90095, United States
University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 5128)
Orange, California, 92868, United States
Om Research LLC ( Site 5045)
Oxnard, California, 93030, United States
Clinical Applications Laboratories ( Site 5123)
San Diego, California, 92103, United States
Amicis Research Center ( Site 5055)
Valencia, California, 91355, United States
University of Colorado Anschutz Medical Campus-Division of Gastroenterology and Hepatology ( Site 5026)
Aurora, Colorado, 80045, United States
Peak Gastroenterology Associates ( Site 5023)
Colorado Springs, Colorado, 80907, United States
South Denver Gastroenterology, PC ( Site 5132)
Englewood, Colorado, 80113, United States
Rocky Mountain Gastroenterology ( Site 5082)
Lakewood, Colorado, 80228, United States
Medical Research Center of Connecticut ( Site 5005)
Hamden, Connecticut, 06518, United States
Yale University School of Medicine-Digestive Disease ( Site 5019)
New Haven, Connecticut, 06510, United States
Emerson Clinical Research Institute ( Site 5051)
Washington D.C., District of Columbia, 20009, United States
Gastroenterology Consultants of Clearwater ( Site 5052)
Clearwater, Florida, 33756, United States
Covenant Metabolic Specialists, LLC ( Site 5150)
Fort Myers, Florida, 33912, United States
Nature Coast Clinical Research - Inverness ( Site 5042)
Inverness, Florida, 34452, United States
Atlantic Medical Research ( Site 5073)
Margate, Florida, 33063, United States
Sanchez Clinical Research ( Site 5144)
Miami, Florida, 33157, United States
AdventHealth Orlando ( Site 5131)
Orlando, Florida, 32803, United States
Endoscopic Research Inc ( Site 5061)
Orlando, Florida, 32803, United States
Orlando Health-Digestive Health Institute ( Site 5010)
Orlando, Florida, 32806, United States
USF Health Carol and Frank Morsani Center for Advanced Healthcare ( Site 5039)
Tampa, Florida, 33612, United States
Covenant Metabolic Specialists, LLC ( Site 5143)
University Park, Florida, 34201, United States
Morehouse School Of Medicine ( Site 5071)
Atlanta, Georgia, 30310, United States
Atlanta Center for Gastroenterology ( Site 5035)
Decatur, Georgia, 30033, United States
Gastroenterology Associates of Central Georgia ( Site 5048)
Macon, Georgia, 31201, United States
Eagle Clinical Research ( Site 5089)
Chicago, Illinois, 60621, United States
University of Chicago Medical Center ( Site 5066)
Chicago, Illinois, 60637, United States
Endeavor Health ( Site 5018)
Evanston, Illinois, 60201, United States
GI ALLIANCE - GURNEE ( Site 5003)
Gurnee, Illinois, 60031, United States
Indiana University Health University Hospital ( Site 5022)
Indianapolis, Indiana, 46202, United States
Iowa Digestive Disease Center ( Site 5007)
Clive, Iowa, 50325, United States
University of Kansas Medical Center ( Site 5091)
Kansas City, Kansas, 66160, United States
Cotton O'Neil Digestive Health Center ( Site 5033)
Topeka, Kansas, 66606, United States
University of Louisville Hospital ( Site 5120)
Louisville, Kentucky, 40202, United States
Southern Clinical Research ( Site 5095)
Zachary, Louisiana, 70791, United States
Walter Reed National Military Medical Center ( Site 5006)
Bethesda, Maryland, 20889, United States
Massachusetts General Hospital-Crohn's and Colitis Center ( Site 5037)
Boston, Massachusetts, 02114, United States
University of Michigan ( Site 5060)
Ann Arbor, Michigan, 48109, United States
Clinical Research Institute of Michigan, LLC ( Site 5002)
Clinton Township, Michigan, 48038, United States
Mayo Clinic in Rochester, Minnesota ( Site 5024)
Rochester, Minnesota, 55905, United States
Mid-America GI Clinical Research ( Site 5130)
Kansas City, Missouri, 64111, United States
BVL Research - Kansas ( Site 5099)
Liberty, Missouri, 64068, United States
Washington University School of Medicine ( Site 5058)
St Louis, Missouri, 63110, United States
HMH Justice Marie Garibaldi Medical Plaza ( Site 5072)
Hackensack, New Jersey, 07601, United States
Northwell Health Physician Partners Center for Advanced IBD Care ( Site 5017)
Great Neck, New York, 11021, United States
Circuit Clinical /Crystal Run Healthcare LLP ( Site 5050)
Middletown, New York, 12589, United States
NYU Langone Health - Inflammatory Bowel Disease Center (IBD) ( Site 5078)
New York, New York, 10016, United States
Weill Cornell Medical College, New-York Presbyterian Hospital ( Site 5079)
New York, New York, 10065, United States
New York Gastroenterology Associates ( Site 5013)
New York, New York, 10075, United States
Northwell Mather Hospital ( Site 5138)
Port Jefferson, New York, 11777, United States
University of North Carolina Medical Center ( Site 5034)
Chapel Hill, North Carolina, 27514, United States
Atrium Health Gastroenterology MMP ( Site 5105)
Charlotte, North Carolina, 28204, United States
Javara - Tryon Medical Partners ( Site 5046)
Charlotte, North Carolina, 28210, United States
Great Lakes Gastroenterology Research, LLC ( Site 5016)
Mentor, Ohio, 44060, United States
Digestive Disease Specialists Inc. ( Site 5117)
Oklahoma City, Oklahoma, 73114, United States
Penn State University Milton S. Hershey Medical Center ( Site 5102)
Hershey, Pennsylvania, 17033, United States
Thomas Jefferson University Hospital ( Site 5133)
Philadelphia, Pennsylvania, 19107, United States
Frontier Clinical Research, LLC ( Site 5098)
Uniontown, Pennsylvania, 15401, United States
University Gastroenterology - Providence - West River Street ( Site 5057)
Providence, Rhode Island, 02904, United States
Sanford USD Medical Center ( Site 5129)
Sioux Falls, South Dakota, 57105, United States
Vanderbilt Inflammatory Bowel Disease Clinic ( Site 5049)
Nashville, Tennessee, 37204, United States
Quality Medical Research ( Site 5114)
Nashville, Tennessee, 37211, United States
Baylor University Medical Center ( Site 5031)
Dallas, Texas, 75246, United States
GI Alliance - Dallas - Gaston Avenue ( Site 5054)
Dallas, Texas, 75246, United States
Epic Medical Research - Mesquite ( Site 5153)
Denton, Texas, 76201, United States
Baylor College of Medicine Medical Center ( Site 5020)
Houston, Texas, 77030, United States
Michael E. DeBakey VA Medical Center ( Site 5086)
Houston, Texas, 77030, United States
GI Alliance - Lubbock ( Site 5012)
Lubbock, Texas, 79410, United States
Caprock Gastro Research ( Site 5077)
Lubbock, Texas, 79424, United States
GI Alliance: Mansfield ( Site 5015)
Mansfield, Texas, 76063, United States
Southern Star Research Institute ( Site 5000)
San Antonio, Texas, 78229, United States
GI Alliance - Southlake ( Site 5109)
Southlake, Texas, 76092-9167, United States
Tyler Research Institute ( Site 5001)
Tyler, Texas, 75701, United States
Richmond VA Medical Center ( Site 5021)
Richmond, Virginia, 23249, United States
Washington Gastroenterology - Bellevue ( Site 5040)
Bellevue, Washington, 98004, United States
Swedish Medical Center ( Site 5112)
Seattle, Washington, 98104, United States
University of Washington ( Site 5115)
Seattle, Washington, 98195, United States
Washington Gastroenterology - Tacoma ( Site 5004)
Tacoma, Washington, 98405, United States
Concord Repatriation General Hospital-Gastroenterology and Liver Services ( Site 3202)
Concord, New South Wales, 2139, Australia
Royal Brisbane and Women's Hospital ( Site 3200)
Brisbane, Queensland, 4029, Australia
Mater Misericordiae Limited ( Site 3209)
Brisbane, Queensland, 4101, Australia
Royal Adelaide Hosp - GI Clinical Trials ( Site 3203)
Adelaide, South Australia, 5000, Australia
Monash Health-Gastroenterology ( Site 3206)
Clayton, Victoria, 3168, Australia
The Alfred Hospital-Gastroenterology ( Site 3201)
Melbourne, Victoria, 3004, Australia
Medizinische Universität Wien-Klinik für Innere Medizin III - Abteilung für Gastroenterologie und H ( Site 0202)
Vienna, State of Vienna, 1090, Austria
Medizinische Universitaet Innsbruck-Innere Medizin 1 ( Site 0200)
Innsbruck, Tyrol, 6020, Austria
Uniklinikum Salzburg-Innere Medizin I ( Site 0201)
Salzburg, 5020, Austria
UZ Gent ( Site 0300)
Ghent, Oost-Vlaanderen, 9000, Belgium
UZ Leuven-Gastroenterology - Inflammatory Bowel Disease ( Site 0301)
Leuven, Vlaams-Brabant, 3000, Belgium
AZ Delta vzw-Gastroenterology ( Site 0304)
Roeselare, West-Vlaanderen, 8800, Belgium
Hospital de Clinicas de Porto Alegre ( Site 6310)
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Hospital Ernesto Dornelles ( Site 6312)
Porto Alegre, Rio Grande do Sul, 90160-093, Brazil
Faculdade de Medicina da UNESP ( Site 6308)
Botucatu, São Paulo, 18618-686, Brazil
Loema Instituto de Pesquisa Clinica ( Site 6302)
Campinas, São Paulo, 13092-133, Brazil
CECIP - Centro de Estudos do Interior Paulista ( Site 6316)
Jaú, São Paulo, 17201-130, Brazil
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP) ( Site 6311)
Ribeirão Preto, São Paulo, 14048-900, Brazil
Pesquisare Saude ( Site 6304)
Santo André, São Paulo, 09080-110, Brazil
Centro de Pesquisa Kaiser - CEPEK ( Site 6306)
São José do Rio Preto, São Paulo, 15015-110, Brazil
BR Trials - Ensaios Clinicos e Consultoria ( Site 6301)
São Paulo, 01236-030, Brazil
Heritage Medical Research Clinic ( Site 0004)
Calgary, Alberta, T2N 4Z6, Canada
Gastroenterology and internal medicine research institute ( Site 0009)
Edmonton, Alberta, T5R 1W2, Canada
Prairie Institute of Liver and Luminal Advanced Research ( Site 0015)
Lethbridge, Alberta, T1J 4G9, Canada
Fraser Clinical Trials Inc ( Site 0001)
New Westminster, British Columbia, V3L 3W4, Canada
G.I.R.I. GI Research Institute Foundation ( Site 0018)
Vancouver, British Columbia, V6Z 2K5, Canada
Private Practice - Dr. Bruce Musgrave ( Site 0014)
Kentville, Nova Scotia, B4N 0A3, Canada
Barrie GI Associates ( Site 0016)
Barrie, Ontario, L4M 7G1, Canada
University Hospital - London Health Sciences Centre ( Site 0002)
London, Ontario, N6A 5A5, Canada
London Health Sciences Centre ( Site 0007)
London, Ontario, N6A 5W9, Canada
West GTA Research Inc. ( Site 0020)
Mississauga, Ontario, L5M 2S4, Canada
ABP Research Services Corp. ( Site 0019)
Oakville, Ontario, L6L 5L7, Canada
Toronto Immune & Digestive Health Institute ( Site 0005)
Toronto, Ontario, M6A 3B4, Canada
TDDA Inc. ( Site 0006)
Vaughan, Ontario, L4L 4Y7, Canada
Centre de recherche du CISSS de Chaudière-Appalaches - Hôpital Hôtel Dieu de Levis ( Site 0011)
Lévis, Quebec, G6V 3Z1, Canada
Centre Hospitalier de l'Université de Montréal - Gastroenterology ( Site 0013)
Montreal, Quebec, H2X 0C1, Canada
Montreal General Hospital ( Site 0003)
Montreal, Quebec, H3G 1A4, Canada
Diex Recherche Quebec ( Site 0008)
Québec, Quebec, G1V 4T3, Canada
Hospital hernan henriquez aravena de temuco ( Site 2607)
Temuco, Araucania, 4781151, Chile
Hospital Clínico Regional Dr. Guillermo Grant Benavente ( Site 2604)
Concepción, Biobio, 4070038, Chile
Clínica Universidad de Los Andes ( Site 2609)
Las Condes, Region M. de Santiago, 7620157, Chile
FALP-UIDO ( Site 2600)
Santiago, Region M. de Santiago, 7500921, Chile
Clínica Alemana de Santiago-Unidad de Investigaciones ( Site 2602)
Santiago, Region M. de Santiago, 7650568, Chile
Espacio Eme ( Site 2608)
Santiago, Region M. de Santiago, 7770086, Chile
CECIM ( Site 2603)
Santiago, Region M. de Santiago, 8320000, Chile
Centro de Investigaciones Clinicas Vina del Mar ( Site 2606)
Viña del Mar, Valparaiso, 2540488, Chile
Anhui Provincial Hospital ( Site 3922)
Hefei, Anhui, 230071, China
Peking University Third Hospital ( Site 3910)
Beijing, Beijing Municipality, 100089, China
Chongqing General Hospital ( Site 3940)
Chongqing, Chongqing Municipality, 401121, China
The First Affiliated Hospital Of Fujian Medical University ( Site 3916)
Fuzhou, Fujian, 350005, China
The First Affiliated hospital of Xiamen University ( Site 3924)
Xiamen, Fujian, 361003, China
Zhongshan Hospital Affiliated to Xiamen University ( Site 3923)
Xiamen, Fujian, 361004, China
Dongguan People's Hospital ( Site 3933)
Dongguan, Guangdong, 523059, China
The First Affiliated Hospital, Sun Yat-sen University ( Site 3901)
Guangzhou, Guangdong, 510655, China
The Sixth Affiliated Hospital of Sun Yat-sen University ( Site 3907)
Guangzhou, Guangdong, 526100, China
Huizhou Municipal Central Hospital ( Site 3915)
Huizhou, Guangdong, 516001, China
Yuebei People's Hospital ( Site 3912)
Shaoguan, Guangdong, 512026, China
The University of Hong Kong-Shenzhen Hospital ( Site 3930)
Shenzhen, Guangdong, 518053, China
Shenzhen Hospital of Southern Medical University ( Site 3932)
Shenzhen, Guangdong, 518110, China
The Second Afilliated Hospital of Hebei Medical University ( Site 3913)
Shijiazhuang, Hebei, 050200, China
The Second Affiliated Hospital of Zhengzhou University ( Site 3909)
Zhengzhou, Henan, 450014, China
Taihe Hospital ( Site 3944)
Shiyan, Hubei, 442099, China
Renmin Hospital of Wuhan University ( Site 3921)
Wuhan, Hubei, 430060, China
The Second Xiangya Hospital of Central South University-gastroenterology department ( Site 3905)
Changsha, Hunan, 410011, China
Huai'an First People's Hospital ( Site 3948)
Huaian, Jiangsu, 230000, China
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School ( Site 3937)
Nanjing, Jiangsu, 210008, China
Zhongda Hospital Southeast University-Gastroenterology ( Site 3911)
Nanjing, Jiangsu, 210009, China
Wuxi People's Hospital ( Site 3925)
Wuxi, Jiangsu, 214023, China
Yangzhou University Affiliated Hospital ( Site 3947)
Yangzhou, Jiangsu, 225000, China
Affiliated Hospital of Jiangsu University ( Site 3919)
Zhenjiang, Jiangsu, 212001, China
Changzhou No.2 People's Hospital ( Site 3904)
Zhenjiang, Jiangsu, 213000, China
Tangdu Hospital of Fourth Military Medical University of Chinese People's Liberation Army ( Site 3918)
Xi'an, Shaanxi, 710038, China
Ruijin Hospital Shanghai Jiaotong University School of Medicine ( Site 3931)
Shanghai, Shanghai Municipality, 200025, China
Huashan Hospital of Fudan University ( Site 3946)
Shanghai, Shanghai Municipality, 200040, China
Shanghai East Hospital ( Site 3914)
Shanghai, Shanghai Municipality, 200120, China
West China Hospital, Sichuan University ( Site 3929)
Chengdu, Sichuan, 610041, China
Suining Central Hospital ( Site 3927)
Suining, Sichuan, 629000, China
First Affiliated Hospital of Kunming Medical University ( Site 3928)
Kunming, Yunnan, 650032, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine-GI Medicine ( Site 3902)
Hangzhou, Zhejiang, 310016, China
Taizhou Hospital of Zhejiang Province ( Site 3936)
Taizhou, Zhejiang, 317000, China
Salud SURA Industriales ( Site 2706)
Medellín, Antioquia, 05001, Colombia
Clinica Medellin S.A ( Site 2705)
Medellín, Antioquia, 050030, Colombia
Fundacion Santa Fe de Bogota ( Site 2703)
Bogotá, Cundinamarca, 110111, Colombia
IMAT S.A.S ( Site 2700)
Montería, Departamento de Córdoba, 23002, Colombia
Oncologos del Occidente ( Site 2702)
Pereira, Risaralda Department, 660001, Colombia
Fundación Valle del Lili ( Site 2704)
Cali, Valle del Cauca Department, 760032, Colombia
Klinička bolnica Merkur ( Site 0503)
Zagreb, City of Zagreb, 10000, Croatia
Klinički bolnički centar Zagreb ( Site 0501)
Zagreb, City of Zagreb, 10000, Croatia
Poliklinika Bates ( Site 0504)
Zagreb, City of Zagreb, 10000, Croatia
Poliklinika Solmed ( Site 0502)
Zagreb, City of Zagreb, 10000, Croatia
Poliklinika Borzan ( Site 0500)
Osijek, County of Osijek-Baranja, 31000, Croatia
KLINICKE CENTRUM Pratia Brno, Pratia Brno s.r.o. ( Site 0657)
Brno, Brno-mesto, 602 00, Czechia
Vojenská Nemocnice Brno-Internal department ( Site 0655)
Brno, Brno-mesto, 615 00, Czechia
Nemocnice Slany-Gastroenterologicka a Endoskopicka ambulance ( Site 0651)
Slaný, Central Bohemia, 274 01, Czechia
Institut Klinicke a Experimentalni Mediciny-Klinika hepatogastroentrologie ( Site 0654)
Prague, Praha 4, 140 21, Czechia
Hepato-Gastroenterologie HK ( Site 0652)
Hradec Králové, 500 12, Czechia
ISCARE klinické centrum ( Site 0656)
Prague, 190 00, Czechia
Herlev and Gentofte Hospital ( Site 5300)
Copenhagen, Capital Region, 2730, Denmark
Odense Universitetshospital ( Site 5301)
Odense, Region Syddanmark, 5000, Denmark
CEMDOE - Centro Médico de Diabetes, Obesidad y Especialidades ( Site 2901)
Santo Domingo, Nacional, 10104, Dominican Republic
Tampereen yliopistollinen sairaala ( Site 5401)
Tampere, Pirkanmaa, 33520, Finland
Pohjois-Karjalan Keskussairaala ( Site 5403)
Joensuu, Pohjois-Karjala, 80210, Finland
Turku University Hospital ( Site 5402)
Turku, Southwest Finland, 20520, Finland
Centre Hospitalier Universitaire de Nice - Hôpital l'Archet ( Site 0711)
Nice, Alpes-Maritimes, 06202, France
CHU Bordeaux Haut-Leveque ( Site 0713)
Pessac, Aquitaine, 33600, France
Assistance Publique Hôpitaux de Marseille - Hôpital Nord ( Site 0722)
Marseille, Bouches-du-Rhone, 13915, France
Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital François Mitterrand ( Site 0708)
Dijon, Bourgogne-Franche-Comté, 21000, France
Centre Hospitalier Universitaire de Reims - Hôpital Robert Debré ( Site 0707)
Reims, Champagne-Ardenne, 51092, France
CHU Besançon ( Site 0724)
Besançon, Doubs, 25000, France
Centre Hospitalier de Valence ( Site 0725)
Valence, Drome, 26953, France
C.H.U. de Nimes. Hopital Caremeau ( Site 0731)
Nîmes, Gard, 30029, France
CHU Rangueil ( Site 0710)
Toulouse, Haute-Garonne, 31059, France
Hopital Beaujon ( Site 0729)
Clichy, Hauts-de-Seine, 92110, France
CMC Ambroise Paré Hartmann - Institut des MICI ( Site 0723)
Neuilly-sur-Seine, Hauts-de-Seine, 92200, France
Clinique des Cèdres ( Site 0732)
Échirolles, Isere, 38130, France
CHU SAINT ELOI ( Site 0701)
Montpellier, Languedoc-Roussillon, 34295, France
Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu ( Site 0705)
Nantes, Loire-Atlantique, 44093, France
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois ( Site 0717)
Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54500, France
Hopital Claude Huriez - CHU de Lille ( Site 0715)
Lille, Nord, 59037, France
centre hospitalier lyon sud ( Site 0716)
Pierre-Bénite, Rhone, 69310, France
CHU d'Amiens-Picardie - Hôpital Sud ( Site 0709)
Amiens, Somme, 80000, France
Hopital Henri Mondor ( Site 0730)
Créteil, Val-de-Marne, 94010, France
Hôpital Saint Antoine ( Site 0721)
Paris, 75012, France
Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre ( Site 0702)
Le Kremlin-Bicêtre, Île-de-France Region, 94275, France
LTD High Technology Hospital Medcenter ( Site 0802)
Batumi, Adjara, 6010, Georgia
Caucasus Medical Centre ( Site 0801)
Tbilisi, Adjara, 0186, Georgia
New Hospitals ( Site 0800)
Tbilisi, 0114, Georgia
Caraps Medline ( Site 0803)
Tbilisi, 0159, Georgia
Siloah St. Trudpert Klinikum-Zentrum für Innere Medizin ( Site 0992)
Pforzheim, Baden-Wurttemberg, 75179, Germany
Klinikum der Universität München Großhadern ( Site 0990)
München, Bavaria, 81377, Germany
klinikum rechts der isar der technischen universität münchen ( Site 0989)
München, Bavaria, 81675, Germany
Universitaetsklinikum Ulm. ( Site 0994)
Ulm, Bavaria, 89081, Germany
Medizinische Hochschule Hannover ( Site 0999)
Hanover, Lower Saxony, 30625, Germany
Klinikum Lüneburg ( Site 0991)
Lüneburg, Lower Saxony, 21339, Germany
Universitätsmedizin Rostock ( Site 0993)
Rostock, Mecklenburg-Vorpommern, 18057, Germany
Evangelisches Krankenhaus Kalk gGmbH ( Site 0986)
Cologne, North Rhine-Westphalia, 51103, Germany
Stadtische Kliniken Duisburg, Abtlg. Innere Medizin ( Site 0985)
Duisburg, North Rhine-Westphalia, 47055, Germany
Gastroenterologische Gemeinschaftspraxis Minden ( Site 0998)
Minden, North Rhine-Westphalia, 32423, Germany
Medizinisches Versorgungszentrum Portal 10 ( Site 0988)
Münster, North Rhine-Westphalia, 48155, Germany
Magen Darm Zentrum Remscheid ( Site 0984)
Remscheid, North Rhine-Westphalia, 42859, Germany
St. Marien und St. Annastift Krankenhaus ( Site 0987)
Ludwighafen Am Rhein, Rhineland-Palatinate, 67067, Germany
Universitätsklinikum Leipzig ( Site 0997)
Leipzig, Saxony, 04103, Germany
Universitaetsklinikum Schleswig-Holstein Campus Kiel ( Site 0995)
Kiel, Schleswig-Holstein, 24105, Germany
Charité Campus Virchow-Klinikum ( Site 0996)
Berlin, 13353, Germany
Universitätsklinikum Brandenburg an der Havel ( Site 0903)
Brandenburg, 14770, Germany
Evangelismos General Hospital of Athens ( Site 1002)
Athens, Attica, 106 76, Greece
THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 1004)
Athens, Attica, 115 27, Greece
General Hospital of Nikaia-Piraeus "Agios Panteleimon" ( Site 1003)
Nikaia Piraeus, Attica, 184 54, Greece
Ippokrateio General Hospital of Thessaloniki ( Site 1001)
Thessaloniki, Central Macedonia, 54642, Greece
University General Hospital of Heraklion-GASTROENTEROLOGY & HEPATOLOGY ( Site 1000)
Heraklion, Crete, 711 10, Greece
Queen Mary Hospital ( Site 3300)
Hksar, Hong Kong
Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház-4. Belgyogyaszat Gasztroenterologia ( Site 1105)
Békéscsaba, Bekescsaba, 5600, Hungary
Heves Vármegyei Markhot Ferenc Oktatókórház és Rendelőintézet ( Site 1117)
Eger, Heves County, 3300, Hungary
Gyöngyösi Bugát Pál Kórház ( Site 1111)
Gyöngyös, Heves County, 3200, Hungary
Komarom-Esztergom Varmegyei Szent Borbala Korhaz ( Site 1115)
Tatabánya, Komárom-Esztergom, 2800, Hungary
VeszLife Magánklinika ( Site 1102)
Veszprém, Veszprém megye, 8200, Hungary
Clinexpert Kft.-Clinexpert Budapest ( Site 1108)
Budapest, 1033, Hungary
Synexus Magyarorszag Kft. (Budapest DRS) ( Site 1107)
Budapest, 1036, Hungary
Semmelweis Egyetem ( Site 1118)
Budapest, 1082, Hungary
Eszak-Pesti Centrumkorhaz-Honvedkorhaz ( Site 1100)
Budapest, 1134, Hungary
Pannónia Magánorvosi Centrum ( Site 1103)
Budapest, 1136, Hungary
Beaumont Hospital, Dublin ( Site 5601)
Dublin, D09 V2NO, Ireland
Emek Medical Center ( Site 1206)
Afula, 1834111, Israel
Barzilai Medical Center ( Site 1209)
Ashkelon, 7830604, Israel
Rambam Health Care Campus ( Site 1201)
Haifa, 3109601, Israel
Bnai Zion Medical Center ( Site 1203)
Haifa, 3339419, Israel
Edith Wolfson Medical Center ( Site 1204)
Holon, 5810001, Israel
Shaare Zedek Medical Center ( Site 1208)
Jerusalem, 9103102, Israel
Meir Medical Center. ( Site 1202)
Kfar Saba, 4428164, Israel
Rabin Medical Center ( Site 1207)
Petah Tikva, 4941492, Israel
Sheba Medical Center ( Site 1200)
Ramat Gan, 5265601, Israel
A.O.U.C. Policlinico di Bari ( Site 1306)
Bari, Apulia, 70124, Italy
Policlinico Universitario Monserrato-SC Gastroenterologia ( Site 1313)
Monserrato, Cagliari, 09042, Italy
Fondazione Policlinico Tor Vergata ( Site 1307)
Rome, Lazio, 00133, Italy
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-Gastroenterology and Endoscopy Unit ( Site 1304)
Milan, Lombardy, 20122, Italy
Istituto Clinico Humanitas-IBD center ( Site 1309)
Rozzano, Lombardy, 20089, Italy
A.O.R.N. Ospedale dei Colli - Monaldi V. ( Site 1310)
Naples, Napoli, 80131, Italy
Ospedale Mauriziano - Gastroenterology Unit ( Site 9000)
Turin, Piedmont, 10128, Italy
Ospedale "Felice Lotti" Di Pontedera ( Site 1311)
Pontedera, Pisa, 56025, Italy
Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO-U.O.S.D. Malattie Infiammatorie Croniche Intestinali ( Site 1302)
Palermo, Sicily, 90146, Italy
Azienda Ospedaliera Universitaria Careggi-MICI ( Site 9002)
Florence, Tuscany, 50134, Italy
Ospedale Sacro Cuore Don G. Calabria-IBD Unit ( Site 1303)
Negrar, Verona, 37024, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1308)
Bologna, 40138, Italy
Azienda Ospedaliera Universitaria Di Messina G. Martino ( Site 1314)
Messina, 98125, Italy
Ospedale San Raffaele-Gastroenterology and Gastrointestinal Endoscopy ( Site 1300)
Milan, 20132, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Dipartimento di Medicina Interna e Gas ( Site 1312)
Roma, 00168, Italy
Aichi Medical University Hospital ( Site 3429)
Nagakute, Aichi-ken, 480-1195, Japan
Nagoya University Hospital ( Site 3445)
Nagoya, Aichi-ken, 466-8560, Japan
Nagoya City University Hospital ( Site 3446)
Nagoya, Aichi-ken, 467-8602, Japan
Tokatsu Tsujinaka Hospital ( Site 3403)
Abiko, Chiba, 270-1168, Japan
Tsujinaka Hospital - Kashiwanoha ( Site 3402)
Kashiwa, Chiba, 277-0871, Japan
Toho University Sakura Medical Center ( Site 3413)
Sakura, Chiba, 285-8741, Japan
Kurume University Hospital ( Site 3419)
Kurume, Fukuoka, 830-0011, Japan
Gunma University Hospital ( Site 3432)
Maebashi, Gunma, 371-8511, Japan
National Hospital Organization Fukuyama Medical Center ( Site 3442)
Fukuyama, Hiroshima, 720-8520, Japan
Sapporo Tokushukai Hospital ( Site 3427)
Sapporo, Hokkaido, 004-0041, Japan
Sapporo Medical University Hospital ( Site 3460)
Sapporo, Hokkaido, 060-8543, Japan
Medical Corporation Sapporo IBD Clinic ( Site 3420)
Sapporo, Hokkaido, 064-0919, Japan
Sapporohigashi Tokushukai Hospital ( Site 3441)
Sapporo, Hokkaido, 065-0033, Japan
Hyogo Medical University Hospital ( Site 3430)
Nishinomiya, Hyōgo, 663-8501, Japan
Hitachi General Hospital ( Site 3438)
Hitachi, Ibaraki, 317-0077, Japan
Tsuchiura Kyodo General Hospital ( Site 3463)
Tsuchiura, Ibaraki, 300-0028, Japan
Tsukuba Memorial Hospital ( Site 3461)
Tsukuba, Ibaraki, 300-2622, Japan
Kanazawa University Hospital ( Site 3436)
Kanazawa, Ishikawa-ken, 920-8641, Japan
Iwate Medical University Hospital ( Site 3457)
Shiwa-gun, Iwate, 028-3695, Japan
Gokeikai Ofuna Chuo Hospital ( Site 3412)
Kamakura, Kanagawa, 247-0056, Japan
St. Marianna University Hospital ( Site 3440)
Kawasaki, Kanagawa, 216-8511, Japan
Matsushima Hospital ( Site 3450)
Yokohama, Kanagawa, 220-0041, Japan
Yokohama City University Medical Center ( Site 3439)
Yokohama, Kanagawa, 232-0024, Japan
Mie University Hospital ( Site 3405)
Tsu, Mie-ken, 514-8507, Japan
Tohoku University Hospital ( Site 3447)
Sendai, Miyagi, 980-8574, Japan
University of the Ryukyus Hospital ( Site 3459)
Ginowan, Okinawa, 901-2725, Japan
Kansai Medical University Hospital ( Site 3409)
Hirakata, Osaka, 573-1191, Japan
Saitama Medical Center ( Site 3452)
Kawagoe, Saitama, 350-8550, Japan
Hamamatsu University Hospital ( Site 3449)
Hamamatsu, Shizuoka, 431-3192, Japan
Matsuda Hospital ( Site 3404)
Hamamatsu, Shizuoka, 432-8061, Japan
National Hospital Organization Shizuoka Medical Center ( Site 3401)
Shimizu, Shizuoka, 411-8611, Japan
Institute of Science Tokyo Hospital ( Site 3437)
Bunkyō, Tokyo, 113-8519, Japan
Ginza Central Clinic ( Site 3407)
Chūō, Tokyo, 104-0061, Japan
Kitasato University Kitasato Institute Hospital ( Site 3458)
Minato, Tokyo, 108-8642, Japan
Toranomon Hospital ( Site 3433)
Minato-ku, Tokyo, 105-8470, Japan
Kyorin University Hospital ( Site 3443)
Mitaka, Tokyo, 181-8611, Japan
The Jikei University Hospital ( Site 3414)
Mitato, Tokyo, 105-8471, Japan
Tokyo Medical University Hospital ( Site 3456)
Shinjuku, Tokyo, 160-0023, Japan
National Center for Global Health and Medicine ( Site 3423)
Shinjuku, Tokyo, 162-8655, Japan
Yamanashi Prefectural Central Hospital ( Site 3435)
Kofu, Yamanashi, 400-8506, Japan
Fukuoka University Hospital ( Site 3417)
Fukuoka, 814-0180, Japan
Japanese Red Cross Fukuoka Hospital ( Site 3462)
Fukuoka, 815-8555, Japan
Hiroshima University Hospital ( Site 3418)
Hiroshima, 734-8551, Japan
Kagoshima University Hospital ( Site 3425)
Kagoshima, 890-8520, Japan
Kagoshima IBD Gastroenterology Clinic ( Site 3428)
Kagoshima, 892-0843, Japan
Coloproctology Center Takano Hospital ( Site 3466)
Kumamoto, 862-0971, Japan
University Hospital,Kyoto Prefectural University of Medicine ( Site 3406)
Kyoto, 602-8566, Japan
National Hospital Organization Kyoto Medical Center ( Site 3411)
Kyoto, 612-8555, Japan
Okayama University Hospital ( Site 3454)
Okayama, 700-8558, Japan
Infusion Clinic ( Site 3408)
Osaka, 530-0011, Japan
National Hospital Organization Osaka National Hospital ( Site 3453)
Osaka, 540-0006, Japan
Saga University Hospital ( Site 3424)
Saga, 849-8501, Japan
Tokyo Yamate Medical Center ( Site 3415)
Tokyo, 169-0073, Japan
Toyama Prefectural Central Hospital ( Site 3410)
Toyama, 930-0975, Japan
Yamagata University Hospital ( Site 3426)
Yamagata, 990-9585, Japan
Pauls Stradins Clinical University Hospital ( Site 5903)
Riga, LV1002, Latvia
SIA M & M Centrs ( Site 5902)
Adazi, Ādaži, 2164, Latvia
Hospital of Lithuanian University of Health Sciences Kauno klinikos-Gastroenterology ( Site 6000)
Kaunas, Kaunas County, 50161, Lithuania
VILNIUS UNIVERSITY HOSPITAL SANTAROS KLINIKOS-Department of Clinical Trials and Pharmacology ( Site 6001)
Vilnius, LT-08661, Lithuania
Hospital Sultanah Aminah ( Site 6104)
Johor Bahru, Johor, 80100, Malaysia
Hospital Universiti Sains Malaysia ( Site 6103)
Kubang Kerian, Kelantan, 16150, Malaysia
University Malaya Medical Centre ( Site 6101)
Lembah Pantai, Kuala Lumpur, 59100, Malaysia
Sarawak General Hospital ( Site 6102)
Kuching, Sarawak, 93586, Malaysia
Hospital Ampang ( Site 6106)
Ampang, Selangor, 68000, Malaysia
Morales Vargas Centro de Investigacion ( Site 3101)
León, Guanajuato, 37000, Mexico
Centro Medico Clinico Quirurgico Especializado en Investigación ( Site 3106)
Tlajomulco de Zúñiga, Jalisco, 45640, Mexico
Centro de Investigación y Gastroenterología - S.C. ( Site 3102)
Mexico City, Mexico City, 03330, Mexico
Medica Sur-Clinica de Enfermedades Digestivas y Obesidad ( Site 3104)
Mexico City, Mexico City, 14050, Mexico
JM Research SC ( Site 3109)
Cuernavaca, Morelos, 62290, Mexico
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Gastroenterología ( Site 3100)
Monterrey, Nuevo León, 64460, Mexico
Servicios de Oncología Médica Integral, S.A de C.V. ( Site 3108)
San Pedro Garza García, Nuevo León, 66220, Mexico
Centro de Investigacion Clinica de Oaxaca ( Site 3105)
Oaxaca City, Oaxaca, 68020, Mexico
Medical Care and Research SA de CV-GASTROENTEROLOGY ( Site 3110)
Mérida, Yucatán, 97070, Mexico
Scientia Investigacion Clinica S.C. ( Site 3114)
Chihuahua City, 31207, Mexico
Radboudumc ( Site 1505)
Nijmegen, Gelderland, 6525 GA, Netherlands
ETZ Elisabeth ( Site 1501)
Tilburg, North Brabant, 5022GC, Netherlands
Ziekenhuis Bernhoven ( Site 1508)
Uden, North Brabant, 5406 PT, Netherlands
Amsterdam UMC, locatie VUmc-IBD Trial Unit ( Site 1500)
Amsterdam, North Holland, 1081 HV, Netherlands
Erasmus Medisch Centrum ( Site 1504)
Rotterdam, South Holland, 3015 GD, Netherlands
Franciscus Gasthuis & Vlietland, Locatie Gasthuis ( Site 1503)
Rotterdam, South Holland, 3045 PM, Netherlands
University Medical Center Groningen ( Site 1506)
Groningen, 9713 GZ, Netherlands
Universitair Medisch Centrum Utrecht ( Site 1502)
Utrecht, 3584 CX, Netherlands
Dunedin Hospital ( Site 3505)
Dunedin, Otago, 9016, New Zealand
Hutt Valley District Health board HVDHB ( Site 3500)
Lower Hutt, Wellington Region, 5010, New Zealand
Aotearoa Clinical Trials ( Site 3501)
Auckland, 2025, New Zealand
Investigaciones Clínicas / Instituto de Ginecología y Reproducción ( Site 3002)
Lima, 15023, Peru
Hospital Cayetano Heredia ( Site 3003)
Lima, Lima 31, Peru
Hospital Nacional Edgardo Rebagliati Martins-Aparato Digestivo ( Site 0154)
Lima, Lima11, Peru
Pratia S.A. Pratia Poznan ( Site 1603)
Poznan, Greater Poland Voivodeship, 60-192, Poland
EMC Instytut Medyczny S.A,Prywatna Lecznica Certus Ambulatoria,Prywatna Lecznica Certus Szpital Nr1 ( Site 1605)
Poznan, Greater Poland Voivodeship, 60-309, Poland
Twoja Przychodnia Poznanskie Centrum Medyczne Sp. z o.o.,Twoja Przychodnia PCM ( Site 1632)
Poznan, Greater Poland Voivodeship, 60-324, Poland
NZOZ Centrum Medyczne KERmed ( Site 1641)
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-231, Poland
Gastromed Sp. z o. o. ( Site 1619)
Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland
Centrum Medyczne Plejady ( Site 1627)
Krakow, Lesser Poland Voivodeship, 30-363, Poland
FutureMeds Krakow ( Site 1628)
Krakow, Lesser Poland Voivodeship, 31-501, Poland
PROMED P. LACH R. GLOWACKI SP. J. ( Site 1636)
Krakow, Lesser Poland Voivodeship, 31-513, Poland
Allmedica ( Site 1602)
Nowy Targ, Lesser Poland Voivodeship, 34-400, Poland
Medicome Sp. z o.o ( Site 1635)
Oświęcim, Lesser Poland Voivodeship, 32-600, Poland
Amicare ( Site 1620)
Jelenia Góra, Lower Silesian Voivodeship, 58-500, Poland
Planetmed ( Site 1600)
Wroclaw, Lower Silesian Voivodeship, 52-210, Poland
Vistamed & Vertigo Sp. z o.o. ( Site 1621)
Wroclaw, Lower Silesian Voivodeship, 53-149, Poland
Melita Medical Sp. z o.o. ( Site 1607)
Wroclaw, Lower Silesian Voivodeship, 53-611, Poland
Penta Hospitals Przychodnie Wrocław Wejherowska ( Site 1601)
Wroclaw, Lower Silesian Voivodeship, 54-239, Poland
Medrise Sp. z o.o. ( Site 1626)
Lublin, Lublin Voivodeship, 20-582, Poland
Uniwersytecki Szpital Kliniczny nr 4 w Lublinie, Kliniczny Oddział Gastroenterologii, Hepatologii i ( Site 1615)
Lublin, Lublin Voivodeship, 20-954, Poland
ETG Zamosc ( Site 1631)
Zamość, Lublin Voivodeship, 22-400, Poland
EB Group Sp. Z o.o. Centrum Zdrowia MDM ( Site 1618)
Warsaw, Masovian Voivodeship, 00-189, Poland
ETG Warszawa ( Site 1629)
Warsaw, Masovian Voivodeship, 02-677, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Gastroenterologii Onkologiczne ( Site 1624)
Warsaw, Masovian Voivodeship, 02-781, Poland
Vivamed Sp. z o.o. ( Site 1623)
Warsaw, Masovian Voivodeship, 03-580, Poland
WIP Warsaw IBD Point Profesor Kierkuś ( Site 1622)
Warsaw, Masovian Voivodeship, 04-501, Poland
Twoja Przychodnia Opolskie Centrum Medyczne ( Site 1633)
Opole, Opole Voivodeship, 45-819, Poland
Endoskopia Sp. z.o.o. ( Site 1637)
Sopot, Pomeranian Voivodeship, 81-756, Poland
M2M ( Site 1630)
Chorzów, Silesian Voivodeship, 41-500, Poland
H-T Centrum Medyczne Endoterapia ( Site 1610)
Tychy, Silesian Voivodeship, 43-100, Poland
Twoja Przychodnia - Szczecinskie Centrum Medyczne ( Site 1612)
Szczecin, West Pomeranian Voivodeship, 71-434, Poland
Sonomed Sp. z o. o. ( Site 1617)
Szczecin, West Pomeranian Voivodeship, 71-685, Poland
IP Clinic ( Site 1638)
Lodz, Łódź Voivodeship, 90-752, Poland
Centrum Medyczne Med-Gastr Sp. z o.o. ( Site 1616)
Lodz, Łódź Voivodeship, 91-034, Poland
AmiCare Sp. z o.o. Sp. k. ( Site 1608)
Lodz, Łódź Voivodeship, 91-495, Poland
Unidade Local de Saúde do Alto Ave - Hospital Senhora da Oliveira ( Site 1704)
Guimarães, Braga District, 4835-044, Portugal
Unidade Local de Saude do Algarve - Hospital de Portimão ( Site 1700)
Portimão, Faro District, 8500-338, Portugal
Unidade Local de Saude da Região de Leiria - Hospital Santo André ( Site 1706)
Leiria, 2410-197, Portugal
Hospital da Luz Lisboa ( Site 1707)
Lisbon, 1500-650, Portugal
Hospital dos Lusíadas Lisboa ( Site 1701)
Lisbon, Portugal
ULSAM - Hospital de Santa Luzia ( Site 1703)
Viana do Castelo, 4900-858, Portugal
Unidade Local de Saude Dão-Lafões - Hospital de São Teotónio ( Site 1702)
Viseu, 3504-509, Portugal
MEMORIAL HEALTHCARE INTERNATIONAL S.R.L ( Site 1806)
Bucharest, Bucharest, 013823, Romania
Fundeni Clinical Institute-Gastroenterology and Hepatology Center ( Site 1808)
Bucharest, Bucharest, 022328, Romania
GastroMed ( Site 1809)
Cluj-Napoca, Cluj, 400394, Romania
Spitalul Clinic Judetean Mures-Gastroenterology ( Site 1807)
Târgu Mureş, Mureș County, 540205, Romania
ASOCIATIA ONCOHELP ( Site 1805)
Timișoara, Timiș County, 300239, Romania
Monza Ares SRL ( Site 1804)
Bucharest, 012015, Romania
King Abdullah Medical City Specialist Hospital ( Site 5230)
Mecca, Makkah Al Mukarramah, 24246, Saudi Arabia
King Abdul Aziz Medical City - AlRiyadh ( Site 5210)
Riyadh, Riyadh Region, 11426, Saudi Arabia
King Saud University Medical City ( Site 5220)
Riyadh, Riyadh Region, 11472, Saudi Arabia
King Faisal Specialist Hospital and Research Center ( Site 5200)
Riyadh, Riyadh Region, 12713, Saudi Arabia
Clinical Hospital Center Dragisa Misovic ( Site 1906)
Belgrade, Beograd, 11 000, Serbia
Clinical Hospital Center Zvezdara-Gastroenterology and hepatology Department ( Site 1903)
Belgrade, Beograd, 11000, Serbia
University Medical Center "Bezanijska kosa"-Gastroenterology and hepatology ( Site 1900)
Belgrade, Beograd, 11080, Serbia
Zemun Medical Centre ( Site 1910)
Zemun, Beograd, 11080, Serbia
General Hospital "Djordje Joanovic" ( Site 1905)
Zrenjanin, Srednjebanatski Okrug, 23000, Serbia
Clinical Center Kragujevac ( Site 1904)
Kragujevac, Sumadijski Okrug, 34000, Serbia
Singapore General Hospital ( Site 6202)
Singapore, Central Singapore, 169608, Singapore
Tan Tock Seng Hospital-Gastroenterology and Hepatology ( Site 6201)
Singapore, Central Singapore, 308433, Singapore
Changi General Hospital ( Site 6203)
Singapore, South East, 529889, Singapore
Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica-Gastroenterologicke oddelenie ( Site 2002)
Banská Bystrica, Banská Bystrica Region, 974 01, Slovakia
Cliniq s.r.o. ( Site 2001)
Bratislava, Bratislava Region, 81109, Slovakia
KM Management ( Site 2000)
Nitra, Nitra Region, 949 01, Slovakia
GASTRO I ( Site 2004)
Prešov, Presov, 080 01, Slovakia
Gastro LM ( Site 2005)
Prešov, Presov, 080 01, Slovakia
Wits Clinical Research ( Site 4004)
Johannesburg, Gauteng, 2193, South Africa
Wits Clinical Research-Chris Hani Baragwanath Hospital ( Site 4005)
Soweto, Gauteng, 2013, South Africa
Panorama Medical Centre ( Site 4001)
Cape Town, Western Cape, 7500, South Africa
Spoke Research ( Site 4003)
Cape Town, Western Cape, 7700, South Africa
Life Kingsbury Hospital ( Site 4000)
Cape Town, Western Cape, 7708, South Africa
Private Practice - Dr. M.N. Rajabally ( Site 4007)
Plumstead, Western Cape, 7800, South Africa
Wonju Severance Christian Hospital-Internal Medicine ( Site 3600)
Wŏnju, Kang-won-do, 26426, South Korea
Korea University Ansan Hospital ( Site 3617)
Ansan-si, Kyonggi-do, 15355, South Korea
The Catholic University Of Korea St. Vincent's Hospital-Gastroenterology ( Site 3608)
Suwon, Kyonggi-do, 16247, South Korea
Dong-A University Hospital ( Site 3601)
Busan, Pusan-Kwangyokshi, 49201, South Korea
Inje University Haeundae Paik Hospital ( Site 3605)
Haeundae-gu, Pusan-Kwangyokshi, 48108, South Korea
Chung-Ang University Hospital ( Site 3606)
Dongjak-gu, Seoul, 06973, South Korea
Kyungpook National Univ.Hospital ( Site 3616)
Daegu, Taegu-Kwangyokshi, 41944, South Korea
Yeungnam Univeristy Medical Center ( Site 3610)
Daegu, Taegu-Kwangyokshi, 42415, South Korea
Keimyung University Dongsan Medical Center ( Site 3614)
Daegu, Taegu-Kwangyokshi, 42601, South Korea
The Catholic University of Korea, Daejeon St. Mary's Hospital ( Site 3604)
Daejeon, Taejon-Kwangyokshi, 34943, South Korea
Kyung Hee University Hospital ( Site 3611)
Seoul, 02447, South Korea
Seoul National University Hospital ( Site 3607)
Seoul, 03080, South Korea
Kangbuk Samsung Hospital-Internal Medicine ( Site 3612)
Seoul, 03181, South Korea
The Catholic University of Korea, Eunpyeong St. Mary's Hospital ( Site 3602)
Seoul, 03312, South Korea
Severance Hospital, Yonsei University Health System-Department of Internal Medicine ( Site 3603)
Seoul, 03722, South Korea
Asan Medical Center ( Site 3609)
Seoul, 05505, South Korea
Samsung Medical Center ( Site 3613)
Seoul, 06351, South Korea
Hospital Germans Trias i Pujol ( Site 2101)
Badalona, Barcelona, 08916, Spain
HOSPITAL CLÍNIC DE BARCELONA-ICMDM - Clinical Institute of Digestive and Metabolic Diseases ( Site 2112)
Barcelona, Catalonia, 08036, Spain
Complejo Hospitalario Universitario de Ferrol ( Site 2114)
A Coruña, La Coruna, 15405, Spain
Hospital Universitario Puerta de Hierro ( Site 2102)
Majadahonda, Madrid, 28222, Spain
Hospital Universitario de Torrejón ( Site 2108)
Torrejón de Ardoz, Madrid, 28850, Spain
Hospital Universitario La Paz ( Site 2100)
Madrid, 28046, Spain
Hospital Montecelo. Complexo Hospitalario de Pontevedra ( Site 2107)
Pontevedra, 36071, Spain
Hospital Universitario Nuestra Senora de la Candelaria ( Site 2105)
Santa Cruz de Tenerife, 38010, Spain
HOSPITAL CLINICO DE VALENCIA-MEDICINA DIGESTIVA ( Site 2103)
Valencia, 46010, Spain
Hospital Universitari i Politecnic La Fe ( Site 2111)
Valencia, 46026, Spain
Hospital Universitario Miguel Servet ( Site 2104)
Zaragoza, 50009, Spain
Danderyds Sjukhus ( Site 5501)
Danderyd, Stockholm County, 182 88, Sweden
Karolinska Universitetssjukhuset Solna ( Site 5500)
Stockholm, Stockholm County, 171 64, Sweden
Universitetssjukhuset i Linköping ( Site 5502)
Linköping, Östergötland County, 581 85, Sweden
University Hospital Basel-Gastroenterology and Hepatology ( Site 2204)
Basel, Canton of Basel-City, 4031, Switzerland
INTESTO-Gastroenterologische Praxis / Crohn-Colitis Zentrum Bern ( Site 2202)
Bern, Canton of Bern, 3012, Switzerland
Cantonal Hospital St.Gallen-Klinik für Gastroenterologie / Hepatologie ( Site 2201)
Sankt Gallen, Canton of St. Gallen, 9000, Switzerland
UniversitätsSpital Zürich-Gastroenterologie & Hepatologie ( Site 2200)
Zurich, Canton of Zurich, 8091, Switzerland
National Taiwan University BioMedical Park Hospital ( Site 3702)
Zhubei, Hsinchu, 302058, Taiwan
National Taiwan University Hospital-Internal Medicine ( Site 3700)
Taipei, 100225, Taiwan
Chang Gung Medical Foundation-Linkou Branch ( Site 3701)
Taoyuan, 33305, Taiwan
Ege Universitesi Hastanesi ( Site 2302)
Bornova, İzmir, 35100, Turkey (Türkiye)
Hacettepe Universitesi Tip Fakultesi Hastanesi ( Site 2300)
Ankara, 06100, Turkey (Türkiye)
ANKARA UNIVERSITY IBNI SINA HOSPITAL-Gastroenterology ( Site 2303)
Ankara, 06230, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi-Gastroenterology ( Site 2301)
Ankara, 06800, Turkey (Türkiye)
Antalya Egitim ve Arastırma Hastanesi ( Site 2304)
Antalya, 07100, Turkey (Türkiye)
Eskisehir Osmangazi University Faculty of Medicine ( Site 2308)
Eskişehir, 26040, Turkey (Türkiye)
Istanbul Universitesi Cerrahpasa Tip Fakultesi Hastanesi ( Site 2306)
Istanbul, 34098, Turkey (Türkiye)
Marmara Univetsitesi Pendik Egitim ve Arastirma Hastanesi ( Site 2305)
Istanbul, 34899, Turkey (Türkiye)
Kocaeli University Medical Faculty Hospital ( Site 2309)
Kocaeli, 41380, Turkey (Türkiye)
Communal non-profit enterprise "Regional clinical hospital of Ivano-Frankivsk Regional Council" ( Site 5815)
Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76008, Ukraine
Medical Center of Limited ( Site 5806)
Kyiv, Kyivska Oblast, 04050, Ukraine
Center of Family Medicine Plus ( Site 5803)
Kyiv, Kyivska Oblast, 04210, Ukraine
Communal Non-profit Enterprise of Lviv Regional Council "Lviv Regional Clinical Hospital"-proctology ( Site 5809)
Lviv, Lviv Oblast, 79010, Ukraine
Limited liability company "Medical center Health Clinic" ( Site 5807)
Vinnytsia, Vinnytsia Oblast, 21009, Ukraine
Municipal Nonprofit Enterprise "Vinnytsia Regional Clinical Hospital n.a. M. I. Pyrohov of Vinnytsia ( Site 5814)
Vinnytsia, Vinnytsia Oblast, 21018, Ukraine
Clinic of Scientific and Research Institute of Invalid Rehabilitation of VNMU n.a. M.I.Pyrohov ( Site 5812)
Vinnytsia, Vinnytsia Oblast, 21029, Ukraine
Communal Non-Commercial Enterprise "Vinnytsia City Clinical -Clinical Therapeutic Department #1 ( Site 5811)
Vinnytsia, Vinnytsia Oblast, 21029, Ukraine
Municipal Enterprise "Volyn Regional Clinical Hospital" of Volyn Regional Council ( Site 5813)
Lutsk, Volyn Oblast, 43005, Ukraine
Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal" ( Site 5800)
Kyiv, 03057, Ukraine
Dobrobut Medical Center ( Site 5801)
Kyiv, 03151, Ukraine
Medical Center of Private Enterprise "Sygma" ( Site 5808)
Kyiv, 04116, Ukraine
Addenbrooke's Hospital ( Site 2400)
Cambridge, Cambridgeshire, CB2 2QQ, United Kingdom
Royal Devon & Exeter Hospital ... ( Site 2407)
Exeter, Devon, EX2 5DW, United Kingdom
Doncaster Royal Infirmary ( Site 2401)
Doncaster, England, DN2 5LT, United Kingdom
Huddersfield Royal Infirmary ( Site 2409)
Huddersfield, England, HD3 3EA, United Kingdom
Whipps Cross University Hospital-Clinical Research Unit ( Site 2404)
London, England, E11 1NR, United Kingdom
Southampton General Hospital ( Site 2402)
Southampton, Hampshire, SO16 6YD, United Kingdom
University College London Hospital-Clinical Research Facility ( Site 2405)
London, London, City of, NW1 2PG, United Kingdom
The John Radcliffe Hospital ( Site 2406)
Oxford, Oxfordshire, OX3 9DU, United Kingdom
Southmead Hospital ( Site 2403)
Bristol, South Gloucestershire, BS10 5NB, United Kingdom
Walsall Manor Hospital ( Site 2410)
West Midlands, Walsall, WS2 9PS, United Kingdom
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Medical Director
Merck Sharp & Dohme LLC
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 21, 2024
First Posted
May 28, 2024
Study Start
June 5, 2024
Primary Completion (Estimated)
October 30, 2028
Study Completion (Estimated)
November 12, 2029
Last Updated
June 12, 2026
Record last verified: 2026-06
Data Sharing
- IPD Sharing
- Will share
https://trialstransparency.msdclinicaltrials.com/pdf/ProcedureAccessClinicalTrialData.pdf