Omega-3 Fatty Acid and Colorectal Adenoma

NCT06427109 | Completed

• 1 other identifier: O3FA
• Study Type: observational
• Target: 798
• Locations: 1 country
• Sites: 1

Brief Summary

Patients aged \>40 years who underwent elective colonoscopies were recruited from ten institutions. Patients with a history of colorectal cancer or long-term dietary interventions were excluded. Participants completed a food frequency questionnaire (FFQ) prior to endoscopy. FFQ data were analyzed using energy-, age-, sex-, and body mass index-adjusted models; the dietary supplemental omega-3 intake was analyzed separately. Colonoscopy outcome data, including the adenoma number, pathology, and location, were collected. Participants were stratified into omega-3 consumption quartiles to assess colorectal adenoma incidence trends using P for trend analysis.

Conditions

Colorectal Neoplasms; Adenoma Colon

Outcome Measures

Primary Outcomes (1)

• Incidence of Colorectal adenoma

  among groups with different omega-3 intake levels

  at the completion of the colonoscopy procedure

Interventions

Dietary intake of omega-3 fatty acid DIETARY_SUPPLEMENT

Participants were stratified into omega-3 consumption quartiles to assess colorectal adenoma incidence trends

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Multi-center, nationwide cohort in Korea

You may qualify if:

• all patients aged more than 40 years of age, scheduled for elective colonoscopy.

You may not qualify if:

• inflammatory bowel diseases
• history of colorectal neoplasms
• prior gastrointestinal surgery
• substance abuse including alcohol
• an inability to complete the survey due to emergency endoscopy
• cognitive impairments and those undergoing significant dietary modifications

Sponsors & Collaborators

• DongGuk University: lead

Study Sites (1)

Dongguk University Ilsan Hospital

Goyang-si, Gyeonggi Province, 14353, South Korea

Location

MeSH Terms

Conditions

Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases

Study Officials

• Yun Jeong Lim

  DongGuk University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: May 16, 2024
• First Posted: May 23, 2024
• Study Start: November 1, 2021
• Primary Completion: November 30, 2023
• Study Completion: February 21, 2024
• Last Updated: May 24, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)