A Prospective, Single-arm, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Tafolecimab and Sintilimab Combined With Chemotherapy in Patients With Advanced or Metastatic Driver Gene-negative Non-small Cell Lung Cancer After Failure of First-line Immunotherapy.

NCT06421298 | Recruiting Phase 2

• 1 other identifier: Immune rechallenge
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The second-line treatment for patients who have progressed after first-line immune checkpoint inhibitor therapy, is chemotherapy based on docetaxel and other drugs. The treatment effect is limited. The median survival time of them are 6 months. So there is a huge unmet medical need. This study is a Prospective, Single-arm, Phase II Clinical Trial to Evaluate the Efficacy and Safety of Tafolecimab and Sintilimab Combined With Chemotherapy in Patients With Advanced or Metastatic Driver Gene-negative Non-small Cell Lung Cancer After Failure of First-line Immunotherapy. 30 patients will be enrolled. The main endpoint is PFS，and the secondary endpoint are OS,DCR,DOR,ORR, and so on.

Conditions

Lung Cancer

Keywords

Immune rechallenge

Outcome Measures

Primary Outcomes (1)

• PFS

  PFS defined as the time from first dose of study treatment until the first date of either objective disease progression or death due to any cause.

  up to 24 months

Secondary Outcomes (5)

• OS

  up to 24 months

• DCR

  up to 24 months

• DOR

  up to 24 months

• ORR

  up to 24 months

• AE

  up to 24 months

Other Outcomes (2)

• To explore the use of iRECIST to evaluate the efficacy treatment of tolecizumab

  up to 24 months

• Explore potential biomarkers that can predict efficacy, including but not limited to PD-L1 expression levels and TMB.

  up to 24 months

Study Arms (1)

Tafolecimab and Sintilimab Combined With Chemotherapy

EXPERIMENTAL

tafolecimab sintilimab nab-paclitaxel docetaxel gemcitabine

Drug: Tafolecimab; Drug: Sintilimab; Drug: Nab paclitaxel; Drug: Docetaxel; Drug: Gemcitabine

Interventions

Tafolecimab DRUG

450mg Q4W ≤6cycle

Tafolecimab and Sintilimab Combined With Chemotherapy

Sintilimab DRUG

200mg Q3W ≤2years

Tafolecimab and Sintilimab Combined With Chemotherapy

Nab paclitaxel DRUG

130mg/m² Q3W 4-6cycles

Tafolecimab and Sintilimab Combined With Chemotherapy

Docetaxel DRUG

75mg/m² Q3W 4-6cycles

Tafolecimab and Sintilimab Combined With Chemotherapy

Gemcitabine DRUG

1250mg/m² Q3W 4-6cycles

Tafolecimab and Sintilimab Combined With Chemotherapy

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Sign a written informed consent before implementing any procedures related to the trial;
• Age ≥18 years old and ≤75 years old;
• Life expectancy ≥3 months;
• Subjects with histologically or cytologically confirmed locally advanced (IIIB-IIIC), metastatic, or recurrent (Stage IV) NSCLC (International Association for the Study of Lung Cancer and Joint American Committee on Cancer Classification 8th Edition TNM Staging of Lung Cancer) relapse or disease progression following multimodal therapy (radiotherapy, surgical resection, or radical chemoradiotherapy for locally advanced disease);
• \. No EGFR, ALK and other mutations; 7. There was at least one radiographically measurable lesion according to the solid tumor efficacy evaluation criteria (RECIST v1.1 edition). Lesions located in the previous radiation field can be considered measurable lesions if progression is demonstrated; 8. Patients with stable brain metastases or whose brain metastases can be controlled were allowed to enroll; 9. ECOG score was 0-1; 10. With sufficient organ function, subjects must meet the following laboratory indicators:
• Absolute neutrophil count (ANC) ≥1.5x10\^9/L without using granulocyte colony-stimulating factor in the past 14 days;
• Without blood transfusion in the past 14 days, platelets ≥100×10\^9/L;
• Hemoglobin \>9g/dL without blood transfusion or erythropoietin use in the past 14 days;
• Total bilirubin ≤1.5×upper limit of normal (ULN);
• Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are ≤2.5×ULN (subjects with liver metastases are allowed ALT or AST ≤5×ULN);
• Serum creatinine ≤1.5×ULN and creatinine clearance (calculated using Cockcroft-Gault formula) ≥60 ml/min;
• Good coagulation function, defined as international normalized ratio (INR) or prothrombin time (PT) ≤ 1.5 times ULN;
• Euthyroid, defined as thyroid stimulating hormone (TSH) within the normal range. If baseline TSH is outside the normal range, subjects can also be enrolled if total T3 (or FT3) and FT4 are within the normal range;
• Myocardial enzyme spectrum is within the normal range (if the researcher comprehensively judges that simple laboratory abnormalities without clinical significance are also allowed to be included); 11. Female subjects of childbearing potential should undergo a urine or serum pregnancy test with a negative result within 3 days before receiving the first dose of study drug (Day 1 of Cycle 1). If a urine pregnancy test result cannot be confirmed as negative, a blood pregnancy test is required. Women of non-reproductive age were defined as at least 1 year postmenopausal, or had undergone surgical sterilization or hysterectomy; 12. If there is a risk of pregnancy, all subjects (regardless of male or female) need to use low annual failure rate during the entire treatment period until 120 days after the last dose of study drug (or 180 days after the last dose of study drug). Contraceptive measures at 1%; 13. Subjects determined by the researcher to meet the admission criteria;

You may not qualify if:

• The pathology is small cell lung cancer (SCLC), including lung cancer that is a mixture of SCLC and NSCLC;
• Have received the following treatments:
• \) Received systemic anti-tumor treatment within 3 weeks before treatment, such as chemotherapy, targeted therapy, immunotherapy (including Chinese herbal treatment with anti-tumor indications), etc.; 2) Have received any investigational drug treatment within 4 weeks before treatment; 3) Received large doses of immunosuppressive drugs (systemic glucocorticoids exceeding 10 mg/day of prednisone or its equivalent) within 4 weeks before treatment; 4) Have received live attenuated vaccines within 4 weeks before treatment (or plan to receive live attenuated vaccines during the study); 5) Have undergone major surgery (such as open cavity, thoracotomy or Kaifu surgery) within 4 weeks before treatment, or have unhealed surgical wounds, ulcers or fractures.
• \. There is clinically uncontrollable pleural effusion/abdominal effusion (subjects who do not need to drain the effusion or who stop drainage for 3 days without significant increase in effusion can be enrolled);
• \. Subjects who have received chest radiation therapy greater than 30Gy within 6 months before treatment or palliative radiation therapy with a dose of 30Gy or less within 7 days before treatment (palliative treatment for bone lesions or intracranial lesions is allowed) Radiation Therapy);
• \. Active autoimmune disease that requires systemic treatment (such as the use of disease-modifying drugs, glucocorticoids, or immunosuppressants) has occurred within 2 years before the first dose. Replacement therapies (such as thyroxine, insulin, or physiological glucocorticoids for adrenal or pituitary insufficiency, etc.) are not considered systemic treatments;
• \. Known allogeneic organ transplantation (except corneal transplantation) or allogeneic hematopoietic stem cell transplantation;
• \. Those who are known to be allergic to the active ingredients or excipients of tolesimab, the study drug;
• \. Have not fully recovered from toxicity and/or complications caused by any intervention before initiating treatment (i.e., ≤Grade 1 or reaching baseline, excluding fatigue or alopecia);
• \. Known history of human immunodeficiency virus (HIV) infection (i.e. HIV 1/2 antibody positive);
• \. Untreated active hepatitis B (defined as HBsAg positivity and a detected HBV-DNA copy number greater than the upper limit of normal value in the laboratory of the research center);
• Note: Hepatitis B subjects who meet the following criteria can also be enrolled:
• If the HBV viral load is \<1000 copies/ml (200 IU/ml) before the first dose, the subject should receive anti-HBV treatment during the entire study chemotherapy drug treatment period to avoid viral reactivation.
• Subjects with anti-HBc (+), HBsAg (-), anti-HBs (-) and HBV viral load (-) do not need to receive prophylactic anti-HBV treatment, but need to be closely monitored for viral reactivation
• \. Subjects with active HCV infection (HCV antibody positive and HCV-RNA level higher than the lower limit of detection);

Sponsors & Collaborators

• Jinghui Wang: lead

Study Sites (1)

Beijing Chest Hospital, Capital Medical University

Beijing, Beijing Municipality, China

RECRUITING

MeSH Terms

Conditions

Lung Neoplasms

Interventions

sintilimab; Taxes; Docetaxel; Gemcitabine

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Economics; Health Care Economics and Organizations; Taxoids; Cyclodecanes; Cycloparaffins; Hydrocarbons, Alicyclic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Diterpenes; Terpenes; Heterocyclic Compounds; Deoxycytidine; Cytidine; Pyrimidine Nucleosides; Pyrimidines; Heterocyclic Compounds, 1-Ring

Study Officials

• Beijing C Beijing Chest Hospital

  Employment relationship

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jinghui Wang

CONTACT

13683128239; jinghuiwang2006@163.com

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: chief physician

Model Details: Tafolecimab and Sintilimab Combined With Chemotherapy in Patients With Advanced or Metastatic Driver Gene-negative Non-small Cell Lung Cancer After Failure of First-line Immunotherapy.

Study Record Dates

• First Submitted: May 10, 2024
• First Posted: May 20, 2024
• Study Start: May 17, 2024
• Primary Completion (Estimated): May 30, 2027
• Study Completion (Estimated): May 30, 2027
• Last Updated: May 20, 2024

Record last verified: 2024-05

Locations

CN (1)