Inflammation in Acute Cardiovascular Diseases - the CArdiovascular Inflammation Registry (CAIR)

NCT06411340 | Not Yet Recruiting DMC

• 1 other identifier: 334636
• Study Type: observational
• Target: 1,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

Following acute cardiovascular injury, inflammation is vital to activate reparative mechanisms. However, there is compelling evidence implicating excessive inflammation and dysregulated resolution in fibrosis, ventricular remodelling, and heart failure (HF). Recently, the anti-inflammatory agent colchicine reduced cardiovascular events after myocardial infarction (MI) compared to placebo, indicating that targeting inflammation in acute cardiovascular conditions is feasible. Several acute cardiovascular conditions are characterised by inflammation, including myocarditis, MI, and acute heart failure. However, there is large variability in definition, epidemiology, clinical presentation, pathophysiology, and natural history of acute inflammatory cardiovascular diseases. This relates, in part, to the difficulty in performing adequately powered studies. Clinical studies that include sufficient patients and extended observation periods are necessary to address some of these knowledge gaps. This registry aims to collate routinely collected clinical data on patients with acute cardiovascular diseases characterised by inflammation in an observational-based registry. By doing so, the investigators hope to understand the contribution of inflammation to the pathophysiology of acute cardiovascular disease, improve risk stratification, and identify potential novel therapeutic targets.

Conditions

Inflammation; Cardiovascular Diseases; Myocarditis; Pericarditis; Myocardial Infarction; Heart Failure; Heart Diseases

Keywords

Inflammation; Acute cardiovascular disease; Myocarditis; Registry; Electronic health records; Pericarditis; Myocardial infarction

Outcome Measures

Primary Outcomes (1)

• All-cause mortality

  Primary outcome will include all-cause mortality, but will vary by specific research project conducted within the registry.

  1 year

Study Arms (1)

Acute inflammatory cardiac disease

This registry aims to collate routinely collected clinical data on patients with acute cardiovascular diseases.

Other: Observation

Interventions

Observation OTHER

Observation

Acute inflammatory cardiac disease

Eligibility Criteria

• Age: 13 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who are diagnosed with acute cardiovascular diseases can be included in the registry.

You may qualify if:

• Any patient 13 years of age or older with an acute cardiovascular condition requiring hospital admission is eligible.

You may not qualify if:

• \<13 years of age

Sponsors & Collaborators

• King's College London: lead

MeSH Terms

Conditions

Inflammation; Cardiovascular Diseases; Myocarditis; Pericarditis; Myocardial Infarction; Heart Failure; Heart Diseases

Interventions

Observation

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Cardiomyopathies; Myocardial Ischemia; Vascular Diseases; Infarction; Ischemia; Necrosis

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 10 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 8, 2024
• First Posted: May 13, 2024
• Study Start: July 1, 2024
• Primary Completion (Estimated): July 1, 2034
• Study Completion (Estimated): July 1, 2039
• Last Updated: May 14, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share