Insulin Resistance in Relation to Hyperthyroidism and Hypothyroidism

NCT06399796 | Not Yet Recruiting

• 1 other identifier: Thyroid and insulin resistance
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Insulin resistance and its relation to hyperthyrodism and Hypothyroidism

Conditions

Insulin Resistance

Outcome Measures

Primary Outcomes (1)

• The prevalence of diabetes mellitus among patients with thyroid disorders

  to prove the prevalence of diabetes mellitus is elevated among patients with thyroid disorders

  baseline

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Based on determining the main outcome variable, the estimated minimum required sample size is 108cases (36cases in each group ). The sample size was calculated using G\*power software 3.1.9.7., based on the following assumptions: HbA1C was elevated in 22.3% of hypothyroid group and 21% of hyperthyroid group compared to controls group eleveted only in ( 16.1%) Medium effect size was estimate to be 0.3 Main statistical test is chi\_squer test ,goodness of fit Alpha = 0.05, Power = 0.80 Allocation ratio= 1.

You may qualify if:

• Adult pations above 18 years old

You may not qualify if:

• Any patients with Diabetes mellitus

Sponsors & Collaborators

• Assiut University: lead

Related Publications (6)

• Chubb SA, Davis WA, Davis TM. Interactions among thyroid function, insulin sensitivity, and serum lipid concentrations: the Fremantle diabetes study. J Clin Endocrinol Metab. 2005 Sep;90(9):5317-20. doi: 10.1210/jc.2005-0298. Epub 2005 Jun 28.

  PMID: 15985488 BACKGROUND

• Raboudi N, Arem R, Jones RH, Chap Z, Pena J, Chou J, Field JB. Fasting and postabsorptive hepatic glucose and insulin metabolism in hyperthyroidism. Am J Physiol. 1989 Jan;256(1 Pt 1):E159-66. doi: 10.1152/ajpendo.1989.256.1.E159.

  PMID: 2643338 BACKGROUND

• Clement K, Viguerie N, Diehn M, Alizadeh A, Barbe P, Thalamas C, Storey JD, Brown PO, Barsh GS, Langin D. In vivo regulation of human skeletal muscle gene expression by thyroid hormone. Genome Res. 2002 Feb;12(2):281-91. doi: 10.1101/gr.207702.

  PMID: 11827947 BACKGROUND

• Singh BM, Goswami B, Mallika V. Association between insulin resistance and hypothyroidism in females attending a tertiary care hospital. Indian J Clin Biochem. 2010 Apr;25(2):141-5. doi: 10.1007/s12291-010-0026-x. Epub 2010 May 27.

  PMID: 23105900 BACKGROUND

• Mari A, Ahren B, Pacini G. Assessment of insulin secretion in relation to insulin resistance. Curr Opin Clin Nutr Metab Care. 2005 Sep;8(5):529-33. doi: 10.1097/01.mco.0000171130.23441.59.

  PMID: 16079624 BACKGROUND

• Sanghvi A, Virji MA, Warty V, Dimasi MJ. Differential suppression of lymphocyte cholesterol synthesis by low density lipoprotein and erythrocyte insulin receptors in normolipidemic subjects. Atherosclerosis. 1983 Dec;49(3):307-18. doi: 10.1016/0021-9150(83)90141-7.

  PMID: 6362680 BACKGROUND

MeSH Terms

Conditions

Insulin Resistance

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor

Study Record Dates

• First Submitted: May 1, 2024
• First Posted: May 6, 2024
• Study Start: June 1, 2024
• Primary Completion: June 1, 2025
• Study Completion: July 1, 2025
• Last Updated: May 6, 2024

Record last verified: 2024-05