TBP Survey Among Respiratory Physicians

NCT06390969 | Completed

• 1 other identifier: TBP_survey
• Study Type: observational
• Target: 418
• Locations: 1 country
• Sites: 1

Brief Summary

Tuberculosis is a major infectious disease with a high mortality burden in the Asia-Pacific region and worldwide. Among various types of extrapulmonary tuberculosis, tuberculous pleuritis (TBP) is amongst the most common manifestations. TBP is also a major underlying cause among patients hospitalised with new-onset unilateral pleural effusion. The workup of TBP frequently involves thoracentesis to retrieve pleural fluid and pleural biopsy for microbiological and histological interpretations. However, the diagnostic accuracy of these tests is of unsatisfactory sensitivity, making diagnosing TBP challenging. In addition, certain tests, including pleural fluid adenosine deaminase (ADA), Mycobacterium tuberculosis polymerase chain reaction (MTB PCR), advanced biopsy procedures (e.g. real-time image-guided biopsy, pleuroscopy) are not readily available in developing regions due to scarcity of resources and lack of expertise. All these factors lead to heterogeneous practice in approaching new-onset pleural effusion, interpretation of pleural TB investigations, and timing of TBP treatment initiation among respiratory physicians in different Asia-Pacific regions. The proposed multinational survey aims to understand the real-world clinical practice in approaching patients with new-onset unilateral pleural effusion and diagnosing TBP in Asia-Pacific regions with intermediate to high TB burden. The results will reflect the current practice of diagnosing TBP, clinical and resource discrepancies in investigating TBP, management of TBP and help prioritise the need for further research in TBP

Conditions

Pleural Effusion; Tuberculosis, Pleural

Outcome Measures

Primary Outcomes (1)

• Treatment decision

  the proprtion of respondents that would consider TBP as one of the differential diagnoses when approaching new-onset unilateral pleural effusion

  1 month

Secondary Outcomes (3)

• Test availability

  1 month

• Disease understanding

  1 month

• Treatment decision for suspected tuberculosis

  1 month

Study Arms (1)

Survey respondent

All respiratory doctors who respond to the survey

Other: Survey

Interventions

Survey OTHER

Cross-sectional online survey

Survey respondent

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The questionnaire will be sent via social media, including WhatsApp, Facebook, X (formerly known as Twitter), targeting respiratory physicians practising in various Asia-Pacific regions, especially regions with intermediate to high TB burden, through snowball sampling. These regions include China, Hong Kong, India, Malaysia, Philippines, Singapore, Taiwan (based on the network of the applicants) and beyond.

You may qualify if:

• Respiratory doctors practising in Asia-Pacific region

You may not qualify if:

• Do not consent for the study

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

Chinese University of Hong Kong

Hong Kong, Hong Kong

Location

MeSH Terms

Conditions

Pleural Effusion; Tuberculosis, Pleural

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Pleural Diseases; Respiratory Tract Diseases; Tuberculosis, Extrapulmonary; Tuberculosis; Mycobacterium Infections; Actinomycetales Infections; Gram-Positive Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Infections; Respiratory Tract Infections

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• David SC Hui, MD

  Chinese University of Hong Kong

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: April 26, 2024
• First Posted: April 30, 2024
• Study Start: July 1, 2024
• Primary Completion: November 30, 2024
• Study Completion: February 28, 2025
• Last Updated: March 30, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)