Prospective Evaluation of Patients With Pleural Effusion

NCT05759117 | Recruiting

• 1 other identifier: ProspectivePleuralEffusion
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 2

Brief Summary

Having a pleural effusion is a common reason for being hospitalized, as it usually requires in-patient care for invasive diagnostic and therapeutic procedures. Specific subtypes of pleural effusion may warrant recurrent admissions, a longer hospital stay and consume more healthcare resources. Despite the recent advancement of pleural medicine, better research is increasingly desired to fill the gaps in establishing an early diagnosis and optimal management of pleural effusion from various causes. Local data on different aspects of pleural effusion is also lacking.

Conditions

Pleural Effusion

Outcome Measures

Primary Outcomes (1)

• Aetiology of pleural effusion

  spectrum of aetiology for pleural effusion

  1 month

Secondary Outcomes (2)

• Management of pleural effusion

  1 month

• Prognosis of pleural effusion

  1 month

Study Arms (1)

Pleural effusion

All patients with pleural effusion who will undergo thoracentesis

Procedure: thoracentesis

Interventions

thoracentesis PROCEDURE

A type of pleural procedure that will yield pleural fluid for subsequent analysis

Also known as: chest drain insertion

Pleural effusion

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who have pleural effusion and will undergo thoracentesis for pleural fluid sampling

You may qualify if:

• Patients hospitalized for pleural effusion.
• Pleural tapping will be performed for pleural fluid analysis.
• Aged 18 years old or above

You may not qualify if:

• \- Failed to obtain informed consent due to the patient's refusal or cognitive impairment

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (2)

Chinese University of Hong Kong

Hong Kong, Hong Kong

RECRUITING

Prince of Wales Hospital

Hong Kong, Hong Kong

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

40mL pleural fluid will be collected during thoracentesis or pleural drain insertion, or from collecting bags. The research pleural fluid will be transferred on ice and stored at - 80oC until assay for subsequent approved studies. 6mL blood will be collected. The blood will be centrifuged, and the supernatant will be stored at - 80oC until assay for subsequent approved studies.

MeSH Terms

Conditions

Pleural Effusion

Interventions

Thoracentesis

Condition Hierarchy (Ancestors)

Pleural Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Paracentesis; Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Therapeutics; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• David SC Hui, MD

  Chinese University of Hong Kong

  STUDY DIRECTOR

Central Study Contacts

Ka Pang Chan, MBChB

CONTACT

35052211; chankapang@cuhk.edu.hk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Month
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Lecturer

Study Record Dates

• First Submitted: February 25, 2023
• First Posted: March 8, 2023
• Study Start: September 1, 2022
• Primary Completion: March 31, 2026
• Study Completion: March 31, 2026
• Last Updated: August 31, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

HK (2)