Molecular Analysis for Gastro-Esophageal Cancer: Multicenter Discrete Choice Experiment

NCT06346080 | Recruiting DMC

• 1 other identifier: s68670
• Study Type: interventional
• Target: 2,200
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this survey is to investigate the participants' preference for a specific screening/diagnostic tool to detect and assess gastro-esophageal cancer. The main question it aims to answer are:

• Which diagnostic modality is preferred by patients and the general population?
• Which features of the diagnostic test are most detrimental in the decision-making for one or the other modality?
• Are geographical differences present in regard to the preference for a diagnostic modality? Participants will be asked to complete a survey of 20-25min, including a brief intake regarding their socio-economic status. This approach will allow us to correct for confounding factors.

Conditions

Esophageal Cancer; Gastric Cancer

Keywords

Esophageal cancer; Survey; Gastric cancer

Outcome Measures

Primary Outcomes (2)

• The rate of contribution of diagnostic features to the preference of participants

  A part-worth analysis, expressed as percentage, from a discrete choice experiment (questionnaire) will assess the features that are most important to the participants

  2 years

• The percentage differences in preference of participants between geographical regions

  Differences in preferences will be compared between different geographical regions using chi-squared or McNemar's test

  2 years

Secondary Outcomes (2)

• Assess the rate patient-level demographics influence the importance of a test feature, expressed as an odds ratio

  2 years

• Assess the rate of trade-off demonstrated as odds ratio between cancer-related mortality reduction and costs

  2 years

Study Arms (1)

Survey participants

EXPERIMENTAL

Participants who will complete a survey investigating their preference for diagnosis and assessment of gastro-esophageal cancer

Other: Survey

Interventions

Survey OTHER

Discrete choice survey

Survey participants

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals \>18yo to 75yo (upper age limit of Barrett's surveillance)
• Access to computer or smartphone
• Clear understanding of available languages of the experiment (English, French, Dutch, Spanish, German, Chinese, Japanese)

You may not qualify if:

• Individuals less than 18yo and more than 75yo
• Incarcerated individuals

Sponsors & Collaborators

• KU Leuven: lead

Study Sites (1)

University Hospitals Leuven

Leuven, 3000, Belgium

RECRUITING

MeSH Terms

Conditions

Esophageal Neoplasms; Stomach Neoplasms

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Head and Neck Neoplasms; Digestive System Diseases; Esophageal Diseases; Gastrointestinal Diseases; Stomach Diseases

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Stijn Vanstraelen, MD

  UZ Leuven

  PRINCIPAL INVESTIGATOR

• Philippe Nafteux, MD, PhD

  UZ Leuven

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Stijn Vanstraelen, MD

CONTACT

16346822; stijn.vanstraelen@kuleuven.be

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Model Details: A survey will be conducted in a single group of participants from different geographical regions and backgrounds

Study Record Dates

• First Submitted: March 23, 2024
• First Posted: April 3, 2024
• Study Start: August 1, 2024
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): August 1, 2026
• Last Updated: February 18, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE

Locations

BE (1)