Role of Patient Selection for Pancreatic Resections

NCT06390891 | Completed

• 1 other identifier: PatSelPanc
• Study Type: observational
• Target: 86,073
• Locations: 0 countries
• Sites: N/A

Brief Summary

Pancreatic surgery is complicated and risky, especially for pancreatic cancer. It's been noticed that having these surgeries done at specialized centers can lead to better outcomes and survival rates. However, factors like patient selection and hospital conditions also play an important role. Some studies show that more surgeries done at a hospital might not always mean better results, as the type of patients and procedures can vary. To understand this better, the present study compared outcomes and patient characteristics between high-volume pancreatic centers and others.

Conditions

Pancreas Disease

Keywords

Specialization; Pancreatic Surgery; Resection; Volume-Outcome-Relationship

Outcome Measures

Primary Outcomes (1)

• In-hospital mortality

  Death

  30 days

Study Arms (2)

Patients treated in high-volume pancreatic centers

Patients treated at a hospital performing at least 50 pancreatic resection procedures annually during 2010 to 2018

Other: Persons with pancreatic resection in a hospital with at least 50 pancreatic resections annually (observational),

Patients treated in low-volume pancreatic centers

Patients not treated at a hospital performing at least 50 pancreatic resection procedures annually during 2010 to 2018

Other: Persons with pancreatic resection in a hospital not performing at least 50 pancreatic resections annually (observational),

Interventions

Persons with pancreatic resection in a hospital with at least 50 pancreatic resections annually (observational), OTHER

Persons that have undergone a pancreatic resection at a hospital with at least 50 pancreatic resections annually (observational)

Patients treated in high-volume pancreatic centers

Persons with pancreatic resection in a hospital not performing at least 50 pancreatic resections annually (observational), OTHER

Persons that have undergone a pancreatic resection at a hospital with not at least 50 pancreatic resections annually (observational)

Patients treated in low-volume pancreatic centers

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population encompasses all patients that underwent any pancreatic resection procedure in any German hospital (full survey of the German population).

You may qualify if:

• partial or total pancreatic resections between 2010 and 2018

You may not qualify if:

• childhood (\<18 years)
• subjects with a pancreatic transplantation procedure
• missing information on age or gender

Sponsors & Collaborators

• Medizinische Hochschule Brandenburg Theodor Fontane: lead

Related Publications (1)

• Mantke R, Seliger B, Ogino S, Buchler MW, Hunger R. Not Only Caseload but Also Patient Selection Is Predictive of Mortality After Pancreatic Resection. Ann Surg Open. 2024 Dec 30;6(1):e536. doi: 10.1097/AS9.0000000000000536. eCollection 2025 Mar.

  PMID: 40134472 DERIVED

MeSH Terms

Conditions

Pancreatic Diseases

Condition Hierarchy (Ancestors)

Digestive System Diseases

Study Officials

• Rene Mantke, MD, PhD

  Head of Surgery at University Hospital Brandenburg an der Havel

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Surgery

Study Record Dates

• First Submitted: April 25, 2024
• First Posted: April 30, 2024
• Study Start: January 1, 2010
• Primary Completion: December 31, 2018
• Study Completion: December 31, 2018
• Last Updated: April 30, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share