Uterine Artery Diastolic Notching & Apelin-13 and 36

NCT06390202 | Completed

• 1 other identifier: B.10.1.TKH.4.34.H.GP.0.01/31
• Study Type: observational
• Target: 88
• Locations: 1 country
• Sites: 1

Brief Summary

This study was conducted to investigate the relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and 36 concentrations between 11 and 14 weeks of gestation.

Conditions

Diagnosis

Keywords

uterine artery; apelin-13; apelin-36; Doppler

Outcome Measures

Primary Outcomes (2)

• Relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.

  Relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.

  through study completion, an average of 1 year

• Relationship between high pulsatility index on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.

  Relationship between high pulsatility index on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.

  through study completion, an average of 1 year

Study Arms (2)

Uterine artery notch negative group

Pregnant women who did not have diastolic notching in uterine artery Doppler between the 11th and 14th weeks of pregnancy constituted the uterine artery notch negative group.

Other: no intervention

Uterine artery notch positive group

Pregnant women with unilateral or bilateral diastolic notching detected in uterine artery Doppler between the 11th and 14th weeks of pregnancy formed the uterine artery notch positive group.

Other: no intervention

Interventions

no intervention OTHER

there is no intervention in this study

Uterine artery notch negative group; Uterine artery notch positive group

Eligibility Criteria

• Age: 18 Years - 39 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

44 singleton pregnant women with unilateral or bilateral diastolic notching detected in uterine artery Doppler between the 11th and 14th weeks of pregnancy formed the study group (uterine artery notch positive group). 44 singleton pregnant women who did not have diastolic notching in uterine artery Doppler between the 11th and 14th weeks of pregnancy constituted the control group (uterine artery notch negative group).

You may qualify if:

• Nonsmokers,
• Singleton pregnancies between 11 and 14 weeks of gestation
• Pregnant women who did not conceive with assisted reproductive methods

You may not qualify if:

• Smokers
• Pregnant women who conceived with assisted reproductive techniques
• Pregnant women with multiple pregnancies
• Pregnant women who started with multiples and continued with singletons
• Pregnant women with any pregestational disease, thrombophilia
• Pregnant women with any congenital uterine anomaly
• Pregnant women with a history of recurrent pregnancy loss
• Pregnant women using aspirin or heparin

Sponsors & Collaborators

• Umraniye Education and Research Hospital: lead

Study Sites (1)

Ümraniye Training and Research Hospital

Istanbul, Ümraniye, 34764, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Disease

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• İbrahim Kale, Associate professor

  Umraniye Education and Research Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: associate professor

Study Record Dates

• First Submitted: April 22, 2024
• First Posted: April 30, 2024
• Study Start: March 1, 2023
• Primary Completion: October 30, 2023
• Study Completion: January 1, 2024
• Last Updated: April 30, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)