The Relationship Between Systemic Immune Inflammation Index and Disease Activity in Patients With Ankylosing Spondylitis

NCT06094673 | Completed

• 1 other identifier: IstPRMTRH4
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, the aim was to investigate the relationship between SII and other laboratory parameters with disease activity in AS patients and to discuss its usability in the follow-up and treatment process.

Conditions

Ankylosing Spondylitis

Keywords

Ankylosing spondylitis; complete blood count; inflammation

Outcome Measures

Primary Outcomes (5)

• The Systemic Immune Inflammation Index (SII)

  The Systemic Immune Inflammation Index (SII) was calculated by dividing the product of neutrophil and platelet counts by the lymphocyte count.

  through study completion, an average of 1 month

• Neutrophil-to-lymphocyte ratio (NLR)

  NLR is a ratio between the absolute neutrophil count and absolute lymphocyte count.

  through study completion, an average of 1 month

• Platelet to-lymphocyte ratio (PLR)

  PLR is a ratio between the absolute platelet count and absolute lymphocyte count.

  through study completion, an average of 1 month

• Mean platelet volume (MPV)

  MPV blood test measures the average size of patient's platelets

  through study completion, an average of 1 month

• Red blood cell distribution width (RDW)

  A red cell distribution width (RDW) test measures the differences in the volume and size of the red blood cells (erythrocytes).

  through study completion, an average of 1 month

Secondary Outcomes (7)

• C-reactive protein

  through study completion, an average of 1 month

• Erythrocyte sedimentation rate

  through study completion, an average of 1 month

• The Bath Ankylosing Spondylitis Disease Activity Index

  through study completion, an average of 1 month

• The Bath Ankylosing Spondylitis Functional Index

  through study completion, an average of 1 month

• The Bath Ankylosing Spondylitis Metrology Index

  through study completion, an average of 1 month

Interventions

No intervention OTHER

No intervention

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients between the ages of 18 and 65 who have been diagnosed with Ankylosing Spondylitis according to the Modified New York Criteria

You may not qualify if:

• Presence of acute or chronic infection
• Presence of autoimmune diseases other than Ankylosing Spondylitis
• Pregnancy
• Diabetes
• Chronic kidney disease
• Chronic liver disease
• Malignancy
• Cardiovascular disease
• Hematological disease

Sponsors & Collaborators

• Istanbul Physical Medicine Rehabilitation Training and Research Hospital: lead

Study Sites (1)

Istanbul Physical Therapy and Rehabilitation Research and Training Hospital

Istanbul, Bahcelievler, 34147, Turkey (Türkiye)

Location

Related Publications (5)

• Wu J, Yan L, Chai K. Systemic immune-inflammation index is associated with disease activity in patients with ankylosing spondylitis. J Clin Lab Anal. 2021 Sep;35(9):e23964. doi: 10.1002/jcla.23964. Epub 2021 Aug 21.

  PMID: 34418163 RESULT

• Liang T, Chen J, Xu G, Zhang Z, Xue J, Zeng H, Jiang J, Chen T, Qin Z, Li H, Ye Z, Nie Y, Zhan X, Liu C. Platelet-to-Lymphocyte Ratio as an Independent Factor Was Associated With the Severity of Ankylosing Spondylitis. Front Immunol. 2021 Nov 5;12:760214. doi: 10.3389/fimmu.2021.760214. eCollection 2021.

  PMID: 34804047 RESULT

• Choe JY, Lee CU, Kim SK. Association between Novel Hematological Indices and Measures of Disease Activity in Patients with Rheumatoid Arthritis. Medicina (Kaunas). 2023 Jan 6;59(1):117. doi: 10.3390/medicina59010117.

  PMID: 36676741 RESULT

• Satis S. New Inflammatory Marker Associated with Disease Activity in Rheumatoid Arthritis: The Systemic Immune-Inflammation Index. Curr Health Sci J. 2021 Oct-Dec;47(4):553-557. doi: 10.12865/CHSJ.47.04.11. Epub 2021 Dec 31.

  PMID: 35444819 RESULT

• Seng JJB, Kwan YH, Low LL, Thumboo J, Fong WSW. Role of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) in assessing disease control in Asian patients with axial spondyloarthritis. Biomarkers. 2018 May-Jun;23(4):335-338. doi: 10.1080/1354750X.2018.1425916. Epub 2018 Jan 24.

  PMID: 29307233 RESULT

MeSH Terms

Conditions

Spondylitis, Ankylosing; Inflammation

Condition Hierarchy (Ancestors)

Axial Spondyloarthritis; Spondylarthropathies; Spondylarthritis; Spondylitis; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Ankylosis; Joint Diseases; Arthritis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Nur Kesiktas, MD, Prof

  Istanbul Physical Medicine Rehabilitation Training and Research Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 10, 2023
• First Posted: October 23, 2023
• Study Start: June 1, 2023
• Primary Completion: July 1, 2023
• Study Completion: July 2, 2023
• Last Updated: February 20, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)