sTREM-1, sTREM-2, Presepsin, and Periodontitis

NCT05924828 | Completed

• 1 other identifier: atauniperio3
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to compare saliva sTREM-1, sTREM-2, Presepsin levels and sTREM-1/sTREM-2 ratio of participants with/without periodontitis. The main question it aims to answer is there a relationship between saliva sTREM-1, sTREM-2, Presepsin levels, sTREM-1/sTREM-2 ratio and periodontitis. Participants will give saliva samples without any intervention

Conditions

Periodontal Diseases; Periodontitis

Keywords

periodontitis; sTREM-1; sTREM-2; Presepsin

Outcome Measures

Primary Outcomes (1)

• sTREM-1, sTREM-2, Presepsin

  sTREM-1, sTREM-2, Presepsin levels in saliva

  0-1 hours of the diagnosis

Study Arms (2)

Healthy

participants without periodontitis

Other: no intervention

periodontitis

participants with stage-3 periodontitis

Other: no intervention

Interventions

no intervention OTHER

no intervention

Also known as: periodontitis, healthy

Healthy; periodontitis

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

individuals who referred to Atatürk University, Department of Periodontology

You may qualify if:

• Individuals should not have any systemic disease that may or may not require medication, including salivary gland pathologies, and not particularly thyroid organ pathologies.
• Individuals have not been continuously treated with anti-inflammatory, antioxidant or similar drugs in the last 6 months,
• Individuals have not received periodontal treatment until 6 months ago,
• Individuals must have at least 14 teeth
• Patients diagnosed with stage 3 periodontitis

You may not qualify if:

• Having a systemic disease such as cardiovascular, diabetes, hypertension, thyroid organ pathologies, chronic kidney failure
• Being pregnant/breastfeeding
• Being on medication for any reason
• Being a smoker/tobacco user
• Having another periodontal disease other than periodontitis
• Having a chronic inflammatory disease (COPD, asthma)

Sponsors & Collaborators

• Ataturk University: lead

Study Sites (1)

Atatürk University

Erzurum, 25240_, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

saliva

MeSH Terms

Conditions

Periodontal Diseases; Periodontitis

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases

Study Officials

• DİDEM ÖZKAL EMİNOĞLU

  Ataturk University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor

Study Record Dates

• First Submitted: June 21, 2023
• First Posted: June 29, 2023
• Study Start: August 1, 2023
• Primary Completion: October 1, 2023
• Study Completion: December 1, 2023
• Last Updated: January 30, 2024

Record last verified: 2024-01

Locations

TU (1)