Evaluation of VEXUS Score of Patients With Heart Failure in the Intensive Care Unit.

NCT06389708 | Not Yet Recruiting

• 1 other identifier: VEVUS-HF
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Heart failure is a syndrome that progresses with symptoms and signs caused by cardiac dysfunction and results in a shortened life expectancy (1). Acute heart failure resulting in hospitalization is a significant cause of morbidity and mortality. With the increase in the severity of the disease and rapid advances in the treatment of heart failure, these patients are frequently hospitalized and monitored in intensive care. (2) Five years after diagnosis, mortality can be up to 67%. Additionally, it is known that patients with heart failure are hospitalized on average once a year after diagnosis. (3) In a multicenter study, it constituted 14% of 3000 cardiac patients admitted to intensive care units. Additionally, due to longer ICU stays, these patients accounted for 33% of total inpatient days. An increasing number of heart failure patients require intensive care due to respiratory failure, regardless of left ventricular ejection fraction. Heart failure accounts for approximately one-third of patient days in intensive care units, and this burden is increasing. This shows that attention should be paid to the quality of care for patients requiring critical care. (2) Multidisciplinary programs have been implemented to deal with the high prevalence. However, the optimal follow-up frequency is unknown. Therefore, some tools are needed to improve patient prognosis (3). Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker whose values in both urine and plasma have been associated with acute kidney injury (AKI). Although NGAL is an early specific biomarker for AKI, it has not yet come into routine use, but is frequently used in clinical and experimental studies (4). Venous load ultrasonography score (VExUS) is a new systemic congestion scoring method based on inferior vena cava dilation and pulsed wave Doppler (PW-Doppler) morphology of the hepatic, portal and renal veins. It has been proposed as a score to assess systemic congestion.

Conditions

Heart Failure; Acute Kidney Injury

Outcome Measures

Primary Outcomes (3)

• VEXUS

  Venous excess ultrasound score

  at the first day, at the last day

• MORTALİTY

  28 day mortality

  in 28 days

• AKI

  Acute kidney injury rate

  last day

Study Arms (1)

Group 1

heart failure patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

heart failure patients in the ICU

You may qualify if:

• Patients with a life expectancy of more than 24 hours
• \>18 age

You may not qualify if:

• Poor abdominal echogenicity
• age \< 18
• postoperative patients,
• intoxications,
• life expectancy is less than 24 hours,
• pregnancy,
• intraperitoneal pressure \> 15 mm Hg,
• obstructive renal failure or suspected,
• presence of renal artery stenosis,
• patients who have had liver and kidney transplants,
• Presence of liver and kidney tumors,
• patients receiving dialysis treatment,
• single kidney and other kidney abnormalities,
• presence of acute mesenteric ischemia

Sponsors & Collaborators

• Inonu University: lead

MeSH Terms

Conditions

Heart Failure; Acute Kidney Injury

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Central Study Contacts

Ayse B OZER

CONTACT

90-5334478924; abelinozer@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Intensive Care Unit

Study Record Dates

• First Submitted: April 25, 2024
• First Posted: April 29, 2024
• Study Start: May 15, 2024
• Primary Completion: December 15, 2024
• Study Completion: January 15, 2025
• Last Updated: May 1, 2024

Record last verified: 2024-04