Effect of Oliceridine on Rebound Pain

NCT06382896 | Recruiting

• 1 other identifier: FirstAHXiamenU-YB-2
• Study Type: observational
• Target: 320
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this clinical study was to identify the risk factors for postoperative pain outburst in patients undergoing arthroscopic knee surgery after Oliceridine and nerve block, and to evaluate the effect of oxeridine on early rehabilitation exercise in patients. A total of 320 patients undergoing arthroscopic knee arthroscopy under general anesthesia combined with femoral nerve block were selected to record the time and duration of postoperative pain outbreak, pain degree, age, gender, operation type, previous surgical history and other related risk factors.

Conditions

Rebound Pain; Arthroscopic Knee Surgery; Oliceridine

Outcome Measures

Primary Outcomes (7)

• Time of onset of postoperative rebound pain

  The numerical rating scale was used

  Within 48 hours after surgery

• The duration of the rebound pain

  The numerical rating scale was used

  Within 48 hours after surgery

• The degree of the rebound pain

  The numerical rating scale was used

  Within 48 hours after surgery

• age

  Fill in the postoperative questionnaire

  Within 48 hours after surgery

• sex

  Fill in the postoperative questionnaire

  Within 48 hours after surgery

• Surgical procedure

  Fill in the postoperative questionnaire

  Within 48 hours after surgery

• Previous surgical history

  Fill in the postoperative questionnaire

  Within 48 hours after surgery

Secondary Outcomes (1)

• Movement recovery time

  Within 7 days of surgery

Study Arms (1)

Patients undergoing ambulatory arthroscopic knee surgery

Other: No intervention

Interventions

No intervention OTHER

This was an observational study

Patients undergoing ambulatory arthroscopic knee surgery

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

General anesthesia combined with femoral nerve block was selected for knee arthroscopic day surgery

You may qualify if:

• \. Age 18-70 years old;2. Body mass index (BMI) 18-30kg /m2;3. American Society of Anesthesiologists (ASA) Grade I to II;4. Hospital stay \>24h.

You may not qualify if:

• \. Patients who cannot understand the numerical rating scale score and give feedback;2. Known allergy to the drug in the study;3. Infection of puncture site with nerve block;4. Oral analgesics for more than 2 weeks before surgery;5. Long-term use of glucocorticoids;6. Simultaneous surgery on both limbs;7. A psychopath;8. Severe compound trauma;9. Pregnant and lactating women.

Sponsors & Collaborators

• The First Affiliated Hospital of Xiamen University: lead

Study Sites (1)

First Affiliated Hospital of Xiamen University

Xiamen, Fujian, 361000, China

RECRUITING

Central Study Contacts

Bin Yang, doctor

CONTACT

13859986036; yangbin4332@outlook.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 15, 2024
• First Posted: April 24, 2024
• Study Start: January 1, 2024
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: April 25, 2024

Record last verified: 2024-04

Locations

CN (1)