A Cohort Study of Uterine Malignancies

NCT05635123 | Recruiting

• 1 other identifier: IRB-20220352-R
• Study Type: observational
• Target: 6,200
• Locations: 1 country
• Sites: 1

Brief Summary

The purposes of current study were to explore the relationship between cervical cancer/endometrial cancer and demographic information, behavior and life style, pregnancy-related factors, and disease history, and to study the factors affecting the prognosis of cancers. In addition, omics tests were performed on the biological specimens to identify the diagnostic markers and prognostic biomarkers.

Conditions

Cervical Cancer; Endometrial Cancer

Outcome Measures

Primary Outcomes (1)

• progression free survival (PFS)

  progression free survival for patients with cervical cancer or endometrial cancer

  60 months

Interventions

No intervention OTHER

This is a prospective observational study with no intervention.

Eligibility Criteria

• Age: 20 Years - 75 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The investigators establish a population cohort of 6200 women including patients with cervical cancer or endometrial cancer, and women attending to a health check-up.

You may qualify if:

• Age 20-75 years;
• Women with cervical cancer or endometrial cancer with a definite pathological diagnosis for the first time;
• Women attending a health check-up;
• Obtain informed consent and sign an informed consent form.

You may not qualify if:

• Patients who are unable to cooperate with the investigations such as mental disorders or cognitive impairment；
• Patients with cancer other than cervical cancer or endometrial cancer;
• Women who have received hysterectomy or pelvic radiation therapy previously.

Sponsors & Collaborators

• Women's Hospital School Of Medicine Zhejiang University: lead

Study Sites (1)

Women's hospital school of medicine zhejiang university

Hangzhou, Zhejiang, 310000, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood, urine, and surgical tissue samples （cancers） were collected.

MeSH Terms

Conditions

Uterine Cervical Neoplasms; Endometrial Neoplasms

Condition Hierarchy (Ancestors)

Uterine Neoplasms; Genital Neoplasms, Female; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Uterine Cervical Diseases; Uterine Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases

Study Officials

• Hui Wang, PhD

  Women's Hospital School Of Medicine Zhejiang University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Hui Wang, PhD

CONTACT

0571-89998857; wang71hui@zju.deu.cn

Xiao Li, PhD

CONTACT

13958160137; 5198009@zju.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 22, 2022
• First Posted: December 2, 2022
• Study Start: September 15, 2023
• Primary Completion: December 1, 2025
• Study Completion (Estimated): December 1, 2030
• Last Updated: July 17, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)