Indoor Air Quality, Temperature and Cognitive Performance

NCT06380582 | Completed DMC

• 1 other identifier: NL85595.068.23
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

Study design: A cross-over single-blinded treatment design will be used. Participants will undergo 4 different conditions: (1) low air flow and 23°C, (2) low air flow and 35°C, (3) high air flow and 23°C, and (4) high air flow and 35°C. Participants will be blinded to the air quality level; however, it is not possible to blind them to the temperature condition, as they will be able to perceive it as different. Study population: The population consists of healthy young and middle-aged adults of both sexes between 18 and 40 years. Intervention (if applicable): Each participant undergoes 4 conditions in randomized order. Two conditions consist of poor air quality defined as 3,000 ppm carbon dioxide and 23°C or 35°C temperature, respectively.

Conditions

Indoor Air Quality; Temperature; Cognitive Performance

Keywords

Indoor air quality; Temperature; Cognition; Metabolism

Outcome Measures

Primary Outcomes (2)

• Cognition Morning

  Cambridge Neuropsychological Test Automated Battery (CANTAB) once at 11am and once at 230pm

  1 month

• Cognition Afternoon

  Cognitive Ability Task - once at 4pm

  1 month

Secondary Outcomes (6)

• Heart Rate (bpm)

  1 month

• Metabolic Rate (ml/kg/min)

  1 month

• Blood Pressure (mmHg)

  1 month

• Blood samples

  1 month

• Saliva samples

  1 month

Other Outcomes (3)

• Temperature (C)

  1 month

• Humidity %

  1 month

• Carbon dioxide (CO2) concentration (ppm)

  1 month

Study Arms (2)

Air flow

EXPERIMENTAL

low airflow and high airflow

Other: Temperature and Airflow combination

Temperature

EXPERIMENTAL

23C 40%RH or 35C 40%RH

Other: Temperature and Airflow combination

Interventions

Temperature and Airflow combination OTHER

23C 40%Relative Humidity (RH) low airflow, 23C 40%RH high airflow, 35C 40%RH low airflow, 35C 40% high airflow

Air flow; Temperature

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Adults between 18 to 40 years old
• Western-European background
• Generally healthy
• No medication which may influence the outcome parameters. This will be determined on a case-by-case basis. Contraceptive uses for women are allowed and will be verified through a questionnaire.
• Non-smokers or persons who quit smoking more than five years ago

You may not qualify if:

• Participants, who do not want to be informed about unexpected medical findings, or do not wish that their treating physician will be informed, cannot participate in this study
• Individuals with a diagnosed physical or mental disability or attention deficit hyperactivity disorder (ADHD) or depression
• Any medication or medical condition that might interfere with the physiological outcome parameters or in some regards impair cognition
• Unstable body weight (weight gain or loss \>3kg in the past three months)
• Participation in another biomedical study within 1 month prior to screening visit
• Shift workers
• Colour blindness
• Pregnancy
• People with a low haemoglobin or haematocrit concentration
• Not having visited or resided in a warm country in the last 3 months
• Participants with asthma or restricted lung function due to allergies

Sponsors & Collaborators

• Maastricht University Medical Center: lead

Study Sites (1)

Maastricht University

Maastricht, Limburg, 6229ER, Netherlands

Location

MeSH Terms

Interventions

Temperature

Intervention Hierarchy (Ancestors)

Thermodynamics; Physical Phenomena; Weather; Atmosphere; Environment; Ecological and Environmental Phenomena; Biological Phenomena; Meteorological Concepts; Environment, Controlled; Environment and Public Health

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 18, 2024
• First Posted: April 24, 2024
• Study Start: April 25, 2024
• Primary Completion: March 6, 2025
• Study Completion: March 6, 2025
• Last Updated: March 24, 2025

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: Open Access upon request of fully anonymized data after initial analysis

Locations

NL (1)