A Trial of Omeprazole and Low Dose Aspirin to Identify Colorectal Biomarkers of Preventive Efficacy

NCT06378398 | Completed Early Phase 1 FDA Drug

• 4 other identifiers: UMCC 2023.037HUM00247729UMI23-13-011UG1CA242632-01A1
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 2

Brief Summary

This trial will obtain biomarker data on the possible preventive effects of omeprazole and low-dose aspirin in colorectal tissue. Persons who have had 5 or more adenomas, 5 or more serrated polyps, or an incompletely removed adenoma or serrated polyp in the colon or rectum are potentially eligible. Before participating in the study, study staff will explain the study and review the consent form. If you are interested and provide consent, study staff will then confirm your eligibility. Once enrolled, participants will take two 20 mg omeprazole tablets and two 81 mg aspirin tablets each day before the first meal each day for 25-45 days. The study does involve biopsies of the colorectal tissue before and after taking the study medications. The biopsies are samples of tissue, about the size of a grain of rice, that will be taken from the colon or rectum before and after taking the study medications. This is done during a usual, clinical colonoscopy exam and during one more limited exam, called flexible sigmoidoscopy, that is done for the research study. The flexible sigmoidoscopy requires less preparation. Which procedure comes first depends on what fits best with each participant's clinical scenario. Biopsies of both normal mucosa and polyps (if possible) are collected.

Conditions

Colorectal Neoplasia

Outcome Measures

Primary Outcomes (1)

• Identification of biomarkers for omeprazole/aspirin combination treatment in the human colorectum

  The ratio of Ki67 proliferation marker to cleaved caspase 3 apoptosis marker, and changes in gene expression by high throughput RNA sequencing (RNA-Seq).

  up to 45 days from intervention initiation

Secondary Outcomes (1)

• Evaluation of gene expression changes

  up to 45 days from intervention initiation

Study Arms (1)

Intervention

EXPERIMENTAL

Two 20 mg/day omeprazole tablets and two 81 mg/day aspirin tablets taken before the first meal each day for 25-45 days.

Drug: Omeprazole; Drug: Aspirin

Interventions

Omeprazole DRUG

Two 20 mg/day omeprazole tablets taken before the first meal each day for 25-45 days.

Also known as: Prilosec

Intervention

Aspirin DRUG

Two 81 mg/day aspirin tablets taken before the first meal each day for 25-45 days.

Also known as: Bayer Aspirin

Intervention

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18-75
• Individuals who are due for a standard of care colonoscopy.
• Have a prior history of colorectal neoplasia including any ONE of the following:
• Multiple (\>=5) colorectal adenomas on most recent colonoscopy
• Multiple (\>=5) sessile serrated polyps on most recent colonoscopy
• Adenomatous polyps meeting criteria for colon polyposis of unknown etiology (\> 20 lifetime adenomas)
• Serrated polyps meeting criteria for serrated polyposis syndrome
• History of incompletely resected colorectal polyp(s) (adenoma or sessile serrated polyp) on most recent colonoscopy
• Willing to avoid taking non-steroidal anti-inflammatory drugs that are not provided by the study in the 30 days prior to Visit 1 and while on study.
• Willing to avoid taking proton pump inhibitors that are not provided by the study in the 30 days prior to Visit 1 and while on study.
• Women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) for the duration of study participation since endoscopy is not recommended during pregnancy.
• Demonstrate adequate organ and marrow function obtained within the last 60 days as defined below:
• Absolute neutrophil count ≥1,000/microliter
• Platelets ≥100,000/microliter
• Total bilirubin ≤ 1.5 fold of the institutional upper limit of normal Note: Higher total bilirubin levels (≤ 3 mg/dL) can be allowed if due to known benign liver condition such as Gilbert's

You may not qualify if:

• Age 76 or higher since there is an increased risk of GI bleeding and peptic ulcer disease in persons above 75 years of age.
• Pathogenic germline variants in adenomatous polyposis coli (APC) and DNA mismatch repair (MMR) genes associated with Lynch Syndrome, or biallelic pathogenic germline variants in the MutY homologue glycosylase (MUTYH) gene.
• Have a history of allergic reactions attributed to compounds of similar chemical or biologic composition to proton pump inhibitors and/or aspirin.
• Participants may not be receiving any other investigational agents.
• Have a history of prior aspirin or NSAID gastritis with bleeding.
• Currently taking a proton pump inhibitor and unable/unwilling to discontinue use 30 days prior to Visit 1.
• Taking NSAIDs or aspirin \>25% of the time (\>8 days/month) and unable/unwilling to discontinue use 30 days prior to Visit 1 and until Visit 4.
• Currently taking medications associated with increased risk for bleeding (warfarin, Eliquis, Plavix, etc.).
• Currently taking medications that have interactions with omeprazole: atazanavir, erlotinib, levoketoconazole, nelfinavir, pazopanib, rilpivirine, sparsentan, certain azole antifungals (itraconazole, ketoconazole, and posaconazole).
• Have a history of hemophilia, Von Willebrand disease or any other known bleeding diathesis.
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• Individuals who the site physician investigator assesses as at high risk for bleeding due to heavy alcohol use or comorbid conditions.
• Pregnant women are excluded since endoscopy is not recommended while pregnant.
• Have invasive cancer or being treated for invasive cancer at the current time or within the past 36 months, with the exception of cancers curatively removed by surgery, other than melanoma, and stage I and II cervical squamous cell cancers.

Sponsors & Collaborators

• University of Michigan Rogel Cancer Center: lead
• National Cancer Institute (NCI): collaborator

Study Sites (2)

The University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States

Location

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

Location

MeSH Terms

Interventions

Omeprazole; Aspirin

Intervention Hierarchy (Ancestors)

2-Pyridinylmethylsulfinylbenzimidazoles; Sulfoxides; Sulfur Compounds; Organic Chemicals; Pyridines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Benzimidazoles; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Salicylates; Hydroxybenzoates; Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons

Study Officials

• Zora Djuric

  University of Michigan Rogel Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 17, 2024
• First Posted: April 22, 2024
• Study Start: June 14, 2024
• Primary Completion: February 17, 2026
• Study Completion: February 17, 2026
• Last Updated: March 13, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (2)