Investigation of the Effects of Pressure Support Ventilation and Positive Airway Pressure Modes During Extubation

NCT06356649 | Completed

• 1 other identifier: ESOGU2
• Study Type: observational
• Target: 199
• Locations: 1 country
• Sites: 1

Brief Summary

Controlled ventilation is applied to patients intubated for general anesthesia. Additionally, positive end-expiratory pressure (PEEP) and pressure support are mechanical ventilation modes that have been used in general anesthesia practice for many years. When the recovery-extubation phase is reached, intermittent bag-mask ventilation is usually used and the patient is allowed to breathe spontaneously and is extubated when an adequate respiratory level is reached. It has been shown in previous studies that the use of intermittent mask ventilation causes postoperative atelectasis. Different methods have been used to prevent postoperative atelectasis. In our study, we aimed to observe the effect of terminating general anesthesia at the end of the operation and using PEEP and pressure-supported ventilation during the extubation phase on early complications.

Conditions

Anesthesia

Keywords

pressure controlled ventilation; positive end-expiratory pressure; tracheal extubation

Outcome Measures

Primary Outcomes (1)

• Complications developing during recovery-extubation

  desaturation, laryngospasm, bronchospasm, agitation, rescue mask ventilation application, airway obstruction, nausea-vomiting, re-intubation, struggling.

  1 hour

Secondary Outcomes (2)

• hemodynamic changes

  first 24 hours

• hemodynamic data

  during 24 hours

Study Arms (2)

Goup 1

Patients extubated after general anesthesia

Procedure: extubation

Group 2

Patients with complications after extubation

Procedure: extubation

Interventions

extubation PROCEDURE

Complications after extubation

Goup 1; Group 2

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing laparoscopic anesthesia with general anesthesia

You may qualify if:

• Patients over the age of 18 with American Society of Anesthesiology physical classification (ASA) 1-3 who underwent laparoscopic cholecystectomy were included in the study

You may not qualify if:

• The patient does not want to participate in the study.
• Known advanced lung disease, advanced-stage heart disease
• Switching from laparoscopic surgery to open surgery
• Surgical procedure exceeds 120 minutes
• intraoperative bleeding \>500 ml

Sponsors & Collaborators

• Eskisehir Osmangazi University: lead

Study Sites (1)

Eskisehir Osmangazi University Medical Faculty

Eskişehir, Odunpazarı, 26040, Turkey (Türkiye)

Location

Related Publications (4)

• Patel RI, Hannallah RS, Norden J, Casey WF, Verghese ST. Emergence airway complications in children: a comparison of tracheal extubation in awake and deeply anesthetized patients. Anesth Analg. 1991 Sep;73(3):266-70.

  PMID: 1867418 BACKGROUND

• Jeong H, Tanatporn P, Ahn HJ, Yang M, Kim JA, Yeo H, Kim W. Pressure Support versus Spontaneous Ventilation during Anesthetic Emergence-Effect on Postoperative Atelectasis: A Randomized Controlled Trial. Anesthesiology. 2021 Dec 1;135(6):1004-1014. doi: 10.1097/ALN.0000000000003997.

  PMID: 34610099 BACKGROUND

• Juang J, Cordoba M, Ciaramella A, Xiao M, Goldfarb J, Bayter JE, Macias AA. Incidence of airway complications associated with deep extubation in adults. BMC Anesthesiol. 2020 Oct 29;20(1):274. doi: 10.1186/s12871-020-01191-8.

  PMID: 33121440 RESULT

• Ata AR, Cetinkaya D, Yaman F. Investigating the effects of pressure support ventilation and positive end-expiratory pressure during extubation on respiratory system complications. Perioper Med (Lond). 2024 Dec 18;13(1):118. doi: 10.1186/s13741-024-00477-6.

  PMID: 39696646 DERIVED

MeSH Terms

Interventions

Airway Extubation

Intervention Hierarchy (Ancestors)

Airway Management; Therapeutics; Investigative Techniques

Study Officials

• Dilek Çetinkaya

  Eskisehir Osmangazi University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 31, 2024
• First Posted: April 10, 2024
• Study Start: March 15, 2023
• Primary Completion: January 15, 2024
• Study Completion: January 20, 2024
• Last Updated: April 10, 2024

Record last verified: 2024-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)