Comparison of the Efficacy of Peripheral Nerve Blocks in Major Open Gynaecological Cancer Surgery

NCT06342076 | Completed

• 1 other identifier: 2023-596
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this prospective randomized study was to compare the effectiveness of subcostal transversus abdominis plane block or rectus sheath block applied in addition to posterior transversus abdominis plane block for postoperative analgesia in major gynecological cancer surgeries. The main question(s) it aims to answer are: \[Is subcostal transversus abdominis plane block more effective in postoperative analgesia? \] \[Is there a difference in pain scores at 24 hours after surgery? \] Since pain scores within the first 24 hours after surgery will be evaluated, participants will be asked to give a value between 0 and 10 at certain time periods.

Conditions

Postoperative Pain; Postoperative Complications; Analgesia; Regional Anesthesia Morbidity

Outcome Measures

Primary Outcomes (1)

• visuel analog scale

  Our primer aim was to compare postoperative pain scores. The first 24 hours postoperatively were evaluated.Numeric Rating Scale(NRS) was used to assess postoperative pain.6th, 12th, 24th hour NRS values were recorded For example, 0-10 where 0 is no pain and 10 is the worst pain imaginable.

  24 hours postoperatively

Secondary Outcomes (1)

• amount of opioid used

  24 hours postoperatively

Study Arms (2)

Group1: Subcostal transversus abdominis plane block(STAPB)

EXPERIMENTAL

Subcostal transversus abdominis plane block(STAPB)

Procedure: Patients undergoing subcostal transversus abdominis plane block and posterior transversus abdominis plane block; Procedure: Patients undergoing rectus sheat block and posterior transversus abdominis plane block

Group 2: Rectus sheat block(RSB)

EXPERIMENTAL

Rectus sheat block(RSB)

Procedure: Patients undergoing subcostal transversus abdominis plane block and posterior transversus abdominis plane block; Procedure: Patients undergoing rectus sheat block and posterior transversus abdominis plane block

Interventions

Patients undergoing subcostal transversus abdominis plane block and posterior transversus abdominis plane block PROCEDURE

To prevent postoperative pain, the researchers applied a subcostal transversus abdominis plane block in addition to the posterior transversus abdominis plane block to a group of patients who underwent surgery with a midline incision due to major gynecological cancer.

Group 2: Rectus sheat block(RSB); Group1: Subcostal transversus abdominis plane block(STAPB)

Patients undergoing rectus sheat block and posterior transversus abdominis plane block PROCEDURE

To prevent postoperative pain, the researchers applied a rectus sheath block in addition to the posterior transversus abdominis plane block to a group of patients who were operated on through a midline incision due to major gynecological cancer.

Group 2: Rectus sheat block(RSB); Group1: Subcostal transversus abdominis plane block(STAPB)

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \>18 years
• ASA II-III

You may not qualify if:

• Those who are allergic to local anesthetics
• BMI\> 40 kg/m2
• Those with chronic pain
• Those with a history of previous abdominal surgery
• Patients who refuse the use of postoperative patient-controlled analgesia

Sponsors & Collaborators

• Bakirkoy Dr. Sadi Konuk Research and Training Hospital: lead

Study Sites (1)

Başakşehir Çam and Sakura City Hospital

Istanbul, Basaksehir, Turkey (Türkiye)

Location

Related Publications (5)

• Bhatia N, Arora S, Jyotsna W, Kaur G. Comparison of posterior and subcostal approaches to ultrasound-guided transverse abdominis plane block for postoperative analgesia in laparoscopic cholecystectomy. J Clin Anesth. 2014 Jun;26(4):294-9. doi: 10.1016/j.jclinane.2013.11.023. Epub 2014 Jun 2.

  PMID: 24882606 RESULT

• Hebbard PD, Barrington MJ, Vasey C. Ultrasound-guided continuous oblique subcostal transversus abdominis plane blockade: description of anatomy and clinical technique. Reg Anesth Pain Med. 2010 Sep-Oct;35(5):436-41. doi: 10.1097/aap.0b013e3181e66702.

  PMID: 20830871 RESULT

• Yorukoglu HU, Sahin T, Oge Kula A. Transversus Abdominis Plane Block Versus Rectus Sheath Block for Postoperative Pain After Caesarean Delivery: A Randomised Controlled Trial. Turk J Anaesthesiol Reanim. 2023 Feb;51(1):43-48. doi: 10.5152/TJAR.2023.22724.

  PMID: 36847318 RESULT

• Soliz JM, Lipski I, Hancher-Hodges S, Speer BB, Popat K. Subcostal Transverse Abdominis Plane Block for Acute Pain Management: A Review. Anesth Pain Med. 2017 Oct 20;7(5):e12923. doi: 10.5812/aapm.12923. eCollection 2017 Oct.

  PMID: 29696110 RESULT

• Abdelsalam K, Mohamdin OW. Ultrasound-guided rectus sheath and transversus abdominis plane blocks for perioperative analgesia in upper abdominal surgery: A randomized controlled study. Saudi J Anaesth. 2016 Jan-Mar;10(1):25-8. doi: 10.4103/1658-354X.169470.

  PMID: 26955306 RESULT

MeSH Terms

Conditions

Pain, Postoperative; Postoperative Complications; Agnosia

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Perceptual Disorders; Neurobehavioral Manifestations; Nervous System Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Prospective randomize study
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Prospective randomize study

Study Record Dates

• First Submitted: March 21, 2024
• First Posted: April 2, 2024
• Study Start: January 1, 2024
• Primary Completion: March 1, 2024
• Study Completion: March 1, 2024
• Last Updated: June 11, 2024

Record last verified: 2024-06

Locations

TU (1)