Systemic Oxidative Stress Score as a Predictor of Gastric Cancer Survival and Recurrence Risk

NCT06337279 | Completed DMC

• 1 other identifier: FMUUH-0322
• Study Type: observational
• Target: 3,820
• Locations: 1 country
• Sites: 1

Brief Summary

The Systemic Oxidative Stress Score (SOSS) , a comprehensive score reflecting the oxidative stress conditions in the microenvironment, can independently and effectively predict tumor burden and long-term prognosis in GC patients. Nomograms based on SOSS provide a potential and promising model for risk stratification and guiding the implementation of treatment decisions.

Conditions

Gastric Cancer

Keywords

Oxidative stress; Gastric cancer; Recurrence; Disease-free survival; Systemic Oxidative Stress Score

Outcome Measures

Primary Outcomes (2)

• 5-year OS

  Overall survival, death, survival with tumor, deletion.

  5 years or 60 months

• 5-year DFS

  Disease-free survival, death,recurrence

  5 years or 60 months

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study is a multicenter, retrospective cohort investigation involving GC patients who underwent radical gastrectomy at the Fujian Medical University Union Hospital (FMUUH), the First Affiliated Hospital of Gannan Medical University (FAHGMU) and Quzhou Affiliated Hospital of Wenzhou Medical University (QAHWMU) between January 2009 and June 2020.

You may qualify if:

• \) gastroscopic histopathological diagnosis of gastric adenocarcinoma; 2) radical gastrectomy for GC; 3) preoperative examination of oxidative indicators including Fbg, CHOL, ALB, TBIL, DBIL, and CR within seven days before surgery; and 4) the tumor did not invade neighboring organs or had no distant metastasis.

You may not qualify if:

• \) gastroscopic histopathological diagnosis of non-adenocarcinoma, 2) gastric stump cancer, 3) neoadjuvant chemotherapy, 4) other malignant diseases besides GC, 5) incomplete medical records, and 6) patients with GC lost to follow-up.

Sponsors & Collaborators

• Fujian Medical University: lead
• Fujian Medical University Union Hospital: collaborator

Study Sites (1)

Fujian Medical University Union Hospital

Fuzhou, Fujian, 350000, China

Location

MeSH Terms

Conditions

Stomach Neoplasms; Recurrence

Condition Hierarchy (Ancestors)

Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Stomach Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Changming Huang, Prof.

  Fujian Medical University Union Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 22, 2024
• First Posted: March 29, 2024
• Study Start: December 10, 2022
• Primary Completion: August 20, 2023
• Study Completion: March 20, 2024
• Last Updated: March 29, 2024

Record last verified: 2024-03

Locations

CN (1)