Using Radiomics to Predict Neoadjuvant Chemotherapy Efficacy
1 other identifier
observational
193
1 country
1
Brief Summary
Neoadjuvant chemotherapy (NC) is an important treatment for advanced gastric cancer (AGC). However, tools that effectively predict the efficacy of NC before treatment are lacking. Computed tomography images before and after NC were used to construct a deep learning-based radiomics signature to predict the efficacy of NC, prognoses and postoperative adjuvant chemotherapy benefit.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jan 2022
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 4, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
July 10, 2022
CompletedFirst Submitted
Initial submission to the registry
July 12, 2022
CompletedFirst Posted
Study publicly available on registry
July 19, 2022
CompletedJuly 19, 2022
July 1, 2022
5 months
July 12, 2022
July 15, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
AUC for ICSS
The predictive performance of imaging change scoring system before and after neoadjuvant chemotherapy (ICSS)
2022-01-01 to 2022-07-31
AUC for BNCISS
The predictive performance of before neoadjuvant chemotherapy imaging scoring system (BNCISS)
2022-01-01 to 2022-07-31
Secondary Outcomes (2)
overall survival
2010-01-01 to 2022-07-31
disease free survival
2010-01-01 to 2022-07-31
Study Arms (2)
good response to neoadjuvant chemotherapy (GRNC)
Tumor regression grade (TRG) =0 or 1 was defined as a good response to neoadjuvant chemotherapy (GRNC)
poor response to neoadjuvant chemotherapy (PRNC)
TRG=2 or 3 was defined as a poor response to neoadjuvant chemotherapy (PRNC).
Interventions
Tumor regression grade (TRG) =0 or 1 was defined as a good response to neoadjuvant chemotherapy (GRNC), and TRG=2 or 3 was defined as a poor response to neoadjuvant chemotherapy (PRNC).
Eligibility Criteria
Prospective collection and a retrospective analysis of patients seen from January 2010 to December 2018 at Fujian Medical University Union Hospital (FMUUH) and the First Hospital of Lanzhou University (FHLU) who were diagnosed with gastric adenocarcinoma and underwent radical resection yielded 193 neoadjuvant chemotherapy (NC) patients, including 148 cases from FMUUH (derivation cohort) and 45 cases from the FHLU (validation cohort). Of the 148 patients from FMUUH, 139 had computed tomography (CT) images before NC, 141 had CT images after NC, and 132 had CT images before and after NC. All 45 patients in the FHLU underwent CT before and after NC. Patients with concurrent malignant disease, distant metastases, palliative resection, or gastric stump cancer were excluded.
You may qualify if:
- Prospective collection and a retrospective analysis of patients seen from January 2010 to December 2018 at Fujian Medical University Union Hospital (FMUUH) and the First Hospital of Lanzhou University (FHLU) who were diagnosed with gastric adenocarcinoma and underwent radical resection
You may not qualify if:
- Patients with concurrent malignant disease, distant metastases, palliative resection, or gastric stump cancer were excluded.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Gastric Surgery
Fuzhou, Fujian, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Hualong Zheng
291167038@qq.com
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 3 Years
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
July 12, 2022
First Posted
July 19, 2022
Study Start
January 4, 2022
Primary Completion
June 1, 2022
Study Completion
July 10, 2022
Last Updated
July 19, 2022
Record last verified: 2022-07