Intra-articular Platelet-Rich Plasma for Acetabular Labral Tears

NCT06332352 | Completed

• 1 other identifier: 00173470
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Platelets are small cells found in the blood that help form clots and stop bleeding. Platelet-rich plasma is blood that contains more platelets than normal and can be given to help people with pain. Tears of the Labrum to the hip (the cartilage "suction cup" that holds the ball to the socket of the hip) cause hip pain. The study wants to see if a portion of the patient's blood, the platelets, will help relieve hip pain and function. Participation requires completing surveys by email, text message, in person, and/or by telephone. Medical tests will also be done to track the health of participants.

Conditions

Acetabular Labrum Tear

Keywords

Acetabular Labrum Tear; Platelet Rich Plasma

Outcome Measures

Primary Outcomes (1)

• Pain & Function Improvements

  The primary analysis will be an improvement in Harris Hip Scores (HHS) and Visual Analog Scale (VAS) over twelve months. Descriptive statistics will be calculated for patent demographics and clinical characteristics as well as for pre-injection (baseline) and post-injection (at 1, 3, 6, and 12 months) data for VAS and HHS.

  12 Months

Secondary Outcomes (4)

• Visual Analog Scale (VAS)

  12 Months

• Harris Hip Scores (HHS)

  12 Months

• International Hip Outcome Tool (iHOT-12)

  12 Months

• EQ-5D (EuroQual 5D)

  12 Months

Study Arms (1)

Intra-Articular hip injection of PRP

EXPERIMENTAL

Single Group Assignment Recruitment will occur at the University of Utah Orthopedic Center by physician and study staff members medical chart review before patient visits. 45 mL of blood will be collected from eligible participants and processed. A single processed neutrophil-poor PRP injection will be given once to a single hip.

Biological: PRP

Interventions

PRP BIOLOGICAL

Intra-articular hip injection of PRP, Blood Collection 45mL, Processed Neutrophil-Poor PRP, 1 injection to one hip joint.

Intra-Articular hip injection of PRP

Eligibility Criteria

• Age: 18 Years - 49 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age ≤49 years old (i.e., 18 - 49 years old)
• Hip or groin pain with at least 1 positive provocative labral hip maneuver (i.e., Flexion, Adduction, Internal Rotation (FADIR) test, subspine impingement test, scour)
• Radiographs with Tonnis grade \< 2 (i.e., 0 or 1)
• MRI or MRA hip with evidence of acetabular labral tear
• Failure of at least 6 weeks of conservative management \[i.e., activity modification, non-steroidal anti-inflammatory drugs (NSAIDs), and/or physical therapy (PT), other intra-articular injection etc.\]
• Prior diagnostic ultrasound guided hip injection with anesthetic-only providing ≥50% pain relief

You may not qualify if:

• Any prior surgery to the affected hip
• Imaging with evidence of avascular necrosis of the affected hip
• Imaging with evidence of hip dysplasia (i.e. lateral center edge angle of ≤20 degrees)
• Alpha angle of ≥55 degrees of the affected hip
• Intra-articular hip injection within the last 6 months to the affected hip of any injectate with the exception of anesthetic
• Active systemic infection requiring antibiotics or local infection at the site of the injection
• Any prior intra-articular infection of the affected hip
• Any prior fracture of the affected femur or pelvis
• Blood dyscrasia or malignancy
• Non-ambulatory patients
• Patient seeking care with active litigation pending
• Body mass index (BMI) ≥ 35 kg/m2
• Systemic inflammatory arthropathy
• Oral steroids consumed within the last three months

Sponsors & Collaborators

• University of Utah: lead

Study Sites (1)

University of Utah - Department of Orthopaedics

Salt Lake City, Utah, 84108, United States

Location

Related Publications (13)

• Groh MM, Herrera J. A comprehensive review of hip labral tears. Curr Rev Musculoskelet Med. 2009 Jun;2(2):105-17. doi: 10.1007/s12178-009-9052-9. Epub 2009 Apr 7.

  PMID: 19468871 BACKGROUND

• Ishoi L, Nielsen MF, Krommes K, Husted RS, Holmich P, Pedersen LL, Thorborg K. Femoroacetabular impingement syndrome and labral injuries: grading the evidence on diagnosis and non-operative treatment-a statement paper commissioned by the Danish Society of Sports Physical Therapy (DSSF). Br J Sports Med. 2021 Nov;55(22):1301-1310. doi: 10.1136/bjsports-2021-104060. Epub 2021 Sep 16.

  PMID: 34531185 BACKGROUND

• Bsat S, Frei H, Beaule PE. The acetabular labrum: a review of its function. Bone Joint J. 2016 Jun;98-B(6):730-5. doi: 10.1302/0301-620X.98B6.37099.

  PMID: 27235512 BACKGROUND

• Su T, Chen GX, Yang L. Diagnosis and treatment of labral tear. Chin Med J (Engl). 2019 Jan 20;132(2):211-219. doi: 10.1097/CM9.0000000000000020.

  PMID: 30614856 BACKGROUND

• McCarthy JC, Noble PC, Schuck MR, Wright J, Lee J. The Otto E. Aufranc Award: The role of labral lesions to development of early degenerative hip disease. Clin Orthop Relat Res. 2001 Dec;(393):25-37. doi: 10.1097/00003086-200112000-00004.

  PMID: 11764355 BACKGROUND

• Chinzei N, Hashimoto S, Hayashi S, Takayama K, Matsumoto T, Kuroda R. Prediction of intra-articular pathology and arthroscopic outcomes for femoroacetabular impingement and labral tear based on the response to preoperative anaesthetic hip joint injections. Eur J Orthop Surg Traumatol. 2020 May;30(4):737-742. doi: 10.1007/s00590-020-02627-0. Epub 2020 Jan 20.

  PMID: 31960159 BACKGROUND

• Yoong P, Guirguis R, Darrah R, Wijeratna M, Porteous MJ. Evaluation of ultrasound-guided diagnostic local anaesthetic hip joint injection for osteoarthritis. Skeletal Radiol. 2012 Aug;41(8):981-5. doi: 10.1007/s00256-011-1290-4. Epub 2011 Nov 10.

  PMID: 22069031 BACKGROUND

• Byrd JW, Jones KS. Diagnostic accuracy of clinical assessment, magnetic resonance imaging, magnetic resonance arthrography, and intra-articular injection in hip arthroscopy patients. Am J Sports Med. 2004 Oct-Nov;32(7):1668-74. doi: 10.1177/0363546504266480.

  PMID: 15494331 BACKGROUND

• O'Dowd A. Update on the Use of Platelet-Rich Plasma Injections in the Management of Musculoskeletal Injuries: A Systematic Review of Studies From 2014 to 2021. Orthop J Sports Med. 2022 Dec 9;10(12):23259671221140888. doi: 10.1177/23259671221140888. eCollection 2022 Dec.

  PMID: 36532150 BACKGROUND

• Saied AM, Redant C, El-Batouty M, El-Lakkany MR, El-Adl WA, Anthonissen J, Verdonk R, Audenaert EA. Accuracy of magnetic resonance studies in the detection of chondral and labral lesions in femoroacetabular impingement: systematic review and meta-analysis. BMC Musculoskelet Disord. 2017 Feb 16;18(1):83. doi: 10.1186/s12891-017-1443-2.

  PMID: 28209142 BACKGROUND

• Conaway Wea. Predictors of Outcomes of Non-Surgical Management for Acetabular Labral Tears. Orthopaedic Journal of Sports Medicine. 2018;6(3).

  BACKGROUND

• Lim A, Zhu JB, Khanduja V. The Use of Intra-articular Platelet-Rich Plasma as a Therapeutic Intervention for Hip Osteoarthritis: A Systematic Review and Meta-analysis. Am J Sports Med. 2023 Jul;51(9):2487-2497. doi: 10.1177/03635465221095563. Epub 2022 Jun 7.

  PMID: 35971803 BACKGROUND

• De Luigi AJ, Blatz D, Karam C, Gustin Z, Gordon AH. Use of Platelet-Rich Plasma for the Treatment of Acetabular Labral Tear of the Hip: A Pilot Study. Am J Phys Med Rehabil. 2019 Nov;98(11):1010-1017. doi: 10.1097/PHM.0000000000001237.

  PMID: 31162277 BACKGROUND

Study Officials

• Dan Cushman, MD

  University of Utah

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 1, 2024
• First Posted: March 27, 2024
• Study Start: March 20, 2024
• Primary Completion: January 31, 2026
• Study Completion: March 1, 2026
• Last Updated: March 23, 2026

Record last verified: 2025-11

Locations

US (1)