Zinc and Iron Absorption From Common Beans in Young Adult Women

NCT06327529 | Recruiting

• 1 other identifier: 2101814
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Fifteen female study participants will be enrolled in a randomized crossover study to measure fractional and total zinc and iron absorption from four common bean (Phaseolus vulgaris) varieties with varying phytate and polyphenolic contents. Phytate, the storage form of phosphorus in plants, and polyphenols, which contribute to the varied colors of common beans, are natural components of the beans and can reduce zinc and iron bioavailability from these foods.

Conditions

Zinc Absorption; Iron Absorption

Keywords

zinc; iron; absorption; phytate; polyphenols; beans

Outcome Measures

Primary Outcomes (2)

• Fractional Zinc absorption

  amount of zinc absorbed and circulating in blood

  24 hours after first intake

• Fractional Iron absorption

  amount of iron absorbed and circulating in the blood

  24 hours after first intake

Secondary Outcomes (2)

• Total Zinc absorption

  24 hours after first intake

• Total Iron absorption

  24 hours after first intake

Study Arms (4)

Bean Variety 1

EXPERIMENTAL

Enriched with Zinc-67, Iron-57

Other: SER 118

Bean Variety 2

EXPERIMENTAL

Enriched with Zinc-70, Iron-58

Other: LMP 1001

Bean Variety 3

EXPERIMENTAL

Enriched with Zinc-67, Iron-57

Other: LPA 586

Bean Variety 4

EXPERIMENTAL

Enriched with Zinc-70, Iron-58

Other: KAT B1

Interventions

SER 118 OTHER

Bean High in Phytic Acid and High in Inhibitory Polyphenols

Bean Variety 1

LMP 1001 OTHER

Bean Low in Phytic Acid and High in Inhibitory Polyphenols

Bean Variety 2

LPA 586 OTHER

Bean Low in Phytic Acid and Low in Inhibitory Polyphenols

Bean Variety 3

KAT B1 OTHER

Bean High in Phytic Acid and Low in Inhibitory Polyphenols

Bean Variety 4

Eligibility Criteria

• Age: 19 Years - 24 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy eumenorrheic (regular monthly menstrual cycles of 25-30-days in length)
• BMI 18.5 - 30 kg/m2
• Regular consumer of beans, i.e. ≥ 4 servings per month
• Usual iron intake estimated by Food Frequency Questionnaire to be less than the Recommended Daily Allowance (RDA) of 18 mg/d (8)
• Subject is willing and able to comply with the study protocols.
• Subject is willing to participate in all study procedures.

You may not qualify if:

• Dislike or allergy to beans
• Self-reported current or recent pregnancy (within the past 12 months)
• Self-reported recent termination of pregnancy (3 months if abortion in 1st or 2nd trimester, or 12 months if in 3rd trimester)
• Self-reported plans to become pregnant during the study period
• Self-reported cancer
• Self-reported surgery without the past 12 months
• Currently taking prescription drugs, other than for contraception, or any nutritional supplements
• Any daily iron supplementation within the past 12 months.
• Currently breastfeeding
• Any medical conditions affecting iron or zinc metabolism (such as hemochromatosis or sickle cell disease)

Sponsors & Collaborators

• University of California, Davis: lead

Study Sites (1)

Department of Nutrition

Davis, California, 95616, United States

RECRUITING

MeSH Terms

Interventions

atrial natriuretic factor (4-23)NH2, de-Gln(18)-de-Ser(19)-de-Gly(20,22)-de-Leu(21)-

Study Officials

• Andrew G Hall, PhD

  University of California, Davis

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Roberta R Holt, PhD

CONTACT

530-400-5952; rrholt@ucdavis.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Study participants will be masked to the type of bean that they will be receiving.
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: A four arm multi-tracer non-randomized crossover design

Study Record Dates

• First Submitted: March 18, 2024
• First Posted: March 25, 2024
• Study Start: May 1, 2024
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: February 20, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)