Effects of Recursive Self-feedback on Speech Production in Aphasia

NCT06323629 | Recruiting

• 1 other identifier: STUDY006201
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to test the effects of recursive self-feedback procedures on spontaneous speech production in stroke survivors with impaired speech production (aphasia). The main question it aims to answer is:

• To what extent can stroke survivors with aphasia use their self-feedback alone to improve their spontaneous speech production? Participants will be engaged in the following activities:
• They will perform language and cognitive tasks.
• Afterwards, they will receive treatments using tablets and headphones at no cost to them.
• The experimental treatments (recursive self-feedback procedures) entails responding to prompts, listening to playbacks of their speech response and attempt to minimize/correct the errors in the next attempt. This process will be repeated multiple times per prompt.
• The experimental treatments are two: an adaptive version that adapts the complexity of the treatment prompt and a non-adaptive version that does not adapt task complexity.
• Researchers will compare the experimental treatments to see if both have similar effects on improving spontaneous speech production.

Conditions

Aphasia; Stroke

Outcome Measures

Primary Outcomes (2)

• Speaking rate

  Correct words produced per minute

  Within 1 week before treatment and within 1 week after treatment.

• Speech initiation latency in milliseconds

  Latency before retrieving the first correct word in an utterance.

  Within 1 week before treatment and within 1 week after treatment.

Study Arms (2)

Adaptive recursive self-feedback procedure

EXPERIMENTAL

Using a tablet, participants listen to speech playback of their response to a prompt and self-correct/minimize their speech errors in a subsequent attempt. This process is looped multiple times per prompt. It adapts across narrative prompts with low and high complexities.

Behavioral: Adaptive recursive self-feedback procedure

Non-adaptive recursive self-feedback procedure

EXPERIMENTAL

Using a tablet, participants listen to speech playback of their response to a prompt and self-correct/minimize their speech errors in a subsequent attempt. This process is looped multiple times per prompt. However, it only uses narrative prompts with high complexity.

Behavioral: Non-adaptive recursive self-feedback procedure

Interventions

Adaptive recursive self-feedback procedure BEHAVIORAL

The intervention uses self-feedback alone to improve speech production. It adapts the complexity of the treatment tasks.

Adaptive recursive self-feedback procedure

Non-adaptive recursive self-feedback procedure BEHAVIORAL

The intervention uses self-feedback alone to improve speech production. However, it does not adapt the complexity of the treatment tasks.

Non-adaptive recursive self-feedback procedure

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• months post left hemisphere stroke
• Aphasia due to left hemisphere stroke
• Dominant English speaker

You may not qualify if:

• Speech-language deficits due to neurological insults such as Parkinson's disease, neurodegenerative conditions etc.
• Uncorrected sensory impairments.
• Language comprehension impairment.
• Severe cognitive impairment.

Sponsors & Collaborators

• University of South Florida: lead
• Center for Smart Use of Technologies to Assess Real-world Outcomes: collaborator

Study Sites (1)

Brain and Aphasia Recovery Lab, PCD 1030, Department of Communication Sciences and Disorders, University of South Florida

Tampa, Florida, 33620, United States

RECRUITING

MeSH Terms

Conditions

Aphasia; Stroke

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Gerald C. Imaezue, PhD

  University of South Florida

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Gerald C. Imaezue, PhD

CONTACT

(813)974-2464; gimaezue@usf.com

William Burgin, MD

CONTACT

813-259-8577; wburgin@usf.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 21, 2024
• First Posted: March 21, 2024
• Study Start: August 29, 2024
• Primary Completion (Estimated): December 1, 2027
• Study Completion (Estimated): December 1, 2027
• Last Updated: September 14, 2026

Record last verified: 2026-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)