tDCS Effects on Brain Plasticity in Aphasia Treatment

NCT05483556 | Unknown

• 1 other identifier: HSEARS20220211001
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI.

Conditions

Aphasia; Stroke

Keywords

tDCS; MRI; Aphasia; Stroke; Speech therapy

Outcome Measures

Primary Outcomes (1)

• Picture naming

  Picture-naming accuracy and response time for each stimuli will be determined perceptual and calculated using praat software

  Change before, immediately after and two months after the treatment

Secondary Outcomes (1)

• Imaging analysis

  Change before, immediately after and two months after the treatment.

Study Arms (2)

Real tDCS

EXPERIMENTAL

Five post-stroke patients will be allocated by the flip the coin method to the experimental group. Participants will receive anodal tDCS stimulation for 20 minutes

Device: Real tDCS

Sham tDCS

SHAM COMPARATOR

Five participants will be allocated by the flip coin method to the sham comparator group. Participants will receive the tDCS stimulation for the 30s

Device: Sham tDCS

Interventions

Real tDCS DEVICE

An anodal high-definition tDCS of 2 mA lasting for 20 minutes will be delivered to the left inferior frontal gyrus during speech therapy.

Real tDCS

Sham tDCS DEVICE

An anodal high-definition tDCS of 2 mA lasting for 30 seconds will be delivered to the left inferior frontal gyrus during speech therapy.

Sham tDCS

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• History of a single unilateral left-hemispheric stroke,
• Right handedness
• Demonstrated features of Broca's Aphasia
• Cantonese speaker
• Comprehension sufficient to carry out tasks
• No history of other neurological diseases

You may not qualify if:

• Aphasia due to reasons other than Stroke, Traumatic brain injury
• Bilateral or multiple brain lesions
• Wernicke's aphasia and other speech disorders, degenerative, psychiatric or metabolic disorders
• Deaf, blind, pregnant/ or preparing for pregnancy, cognitive issues, tattoos
• Have cochlear implants, pacemaker, surgical nails for bone fracture, artificial joints, dental braces, dentures
• Taking anti-depressant medications

Sponsors & Collaborators

• The Hong Kong Polytechnic University: lead

Study Sites (1)

The Hong Kong Polytechnic University

Kowloon, Hong Kong

RECRUITING

MeSH Terms

Conditions

Aphasia; Stroke; Communication Disorders

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Min Ney Wong, PhD

  The Hong Kong Polytechnic University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Min Ney WONG, PhD

CONTACT

(852) 27667268; min.wong@polyu.edu.hk

Faisal N Baig, PhD

CONTACT

(852) 27666561; faisal.n.baig@polyu.edu.hk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: Double (participant, outcome accessor)
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: July 29, 2022
• First Posted: August 2, 2022
• Study Start: November 1, 2021
• Primary Completion: October 31, 2024
• Study Completion: October 31, 2024
• Last Updated: January 18, 2024

Record last verified: 2024-01

Locations

HK (1)