Perineural and Systemic Dexamethasone Use in Dental Surgeries in Terms of Anesthesia Duration and Postop Complaints

NCT06318013 | Completed

• 1 other identifier: 2022-KAEK-15427-04-204-2022101
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Participants will be asked to use some medications after the tooth extraction procedure. These drugs can be used in different ways. Investigators plan to monitor the pain, swelling and duration of anesthesia in the body as a result of participants use.

Conditions

Impacted Third Molar Tooth

Keywords

Impacted third molar; Dexamethasone; anesthesia duration

Outcome Measures

Primary Outcomes (2)

• Swelling

  In order to determine the course of postoperative edema in patients with tooth extraction, tragus-pogonion (S1), tragus-mouth canthus (S2) and gonion-lateral canthus (S3) will be measured with the help of a tape measure.

  1 week

• Duration of anesthesia

  After anesthesia, the time it takes for numbness to subside will be measured in minutes. A vitalometer device will be used to check that anesthesia has passed.

  6 hours

Secondary Outcomes (1)

• Pain Score

  1 week

Study Arms (3)

Control

Group receiving only local anesthesia

Diagnostic Test: vitality test

Intravenous Dexamethasone

Group using dexamethasone IV

Diagnostic Test: vitality test

Perineural Dexamethasone

group administered perineural dexamethasone

Diagnostic Test: vitality test

Interventions

vitality test DIAGNOSTIC_TEST

A vitality test will be performed using a vitalometer to check if the drowsiness is gone

Control; Intravenous Dexamethasone; Perineural Dexamethasone

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Healthy, male and female patients between the ages of 18-35

You may qualify if:

• ASA class 1, impacted teeth in Class II position B according to the Pell and Gregory classification, with no signs of inflammation and no dental pathology

You may not qualify if:

• Pregnant or breastfeeding women, patients with diabetes, endocrine disease, hypertension patients, patients with bleeding disorders or using anticoagulants

Sponsors & Collaborators

• Karamanoğlu Mehmetbey University: lead

Study Sites (1)

Karamanoğlu Mehmetbey University Ahmet Keleşoğlu Faculty of Dentistry

Karaman, 70100, Turkey (Türkiye)

Location

Related Publications (4)

• Ruthvik S, Krishnan M, George M, Kumar SP, Lakshmanan S. Efficacy of Dexamethasone Diluted Saline Irrigant on Postoperative Sequelae in Patients Undergoing Lower Third Molar Surgery: A Prospective Clinical Study. Cureus. 2023 Sep 18;15(9):e45436. doi: 10.7759/cureus.45436. eCollection 2023 Sep.

  PMID: 37859912 RESULT

• Poorna P, Shetty P, Kalyani V, Shetty S, Upadya M, Mithra P. A comparative evaluation of the effect of addition of 8 mg dexamethasone to 2% lignocaine with adrenaline in mandibular third molar surgery: a split mouth randomised double blind study. Front Oral Health. 2024 Feb 9;5:1349832. doi: 10.3389/froh.2024.1349832. eCollection 2024.

  PMID: 38404531 RESULT

• Priyanga R, Balamurugan R, Rajan PS. Comparison of dexamethasone administration through sublingual and intramuscular routes for evaluation of pain, swelling, and trismus after impacted mandibular third molar surgery-a prospective randomized controlled study. Oral Maxillofac Surg. 2022 Mar;26(1):155-159. doi: 10.1007/s10006-021-00978-4. Epub 2021 Jun 5.

  PMID: 34091813 RESULT

• Kaya DI, Akti A. Comparison of perineural and systemic dexamethasone use in impacted third molar surgeries in terms of anesthesia duration and postoperative complaints: a controlled, randomized observational study. BMC Oral Health. 2024 Jun 18;24(1):706. doi: 10.1186/s12903-024-04483-4.

  PMID: 38890655 DERIVED

Study Officials

• Ahmet Aktı, Dr

  Selcuk University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Target Duration: 1 Week
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: March 12, 2024
• First Posted: March 19, 2024
• Study Start: March 27, 2024
• Primary Completion: April 15, 2024
• Study Completion: May 26, 2024
• Last Updated: May 31, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)