Comperasion the Postoperative Effect of Low Laser Therapy and Platelet Rich Fibrin on Mandibular Third Molar Surgery.

NCT06262945 | Completed

• 1 other identifier: YDU/2024/120-1808
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was investigate the comparison of postoperative effects of low laser treatment and platelet-rich fibrin application on mandibular impacted third molar tooth extraction. The study included a total of 60 patients with impacted mandibular third molar. Patients were evaluated in 4 randomly separated groups. In group 1, PRF was applied to the tooth socket. In group 2, PRF was applied to the tooth socket combined with Low Laser Treatment extraorally to the extraction area for three days within surgery day In group 3, Low Laser Treatment was applied to the extraorally to the extraction area for three days within surgery day. In group 4 (control group), tradional osteomy was made. The outcome variables were pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed based on first, second, third, and seventh days following the operation. All of the 4 groups patients were prescribed an 875/125 mg amoxicillin/clavulanic acid tablet twice daily for five days.

Conditions

Impacted Third Molar Tooth

Keywords

platelet rich fibrin; comparison; low laser therapy; wisdom tooth

Outcome Measures

Primary Outcomes (12)

• Visual analogue scale (VAS)

  It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured.

  Day 1

• Visual analogue scale (VAS)

  It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured.

  Day 2

• Visual analogue scale (VAS)

  It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured.

  Day 3

• Visual analogue scale (VAS)

  It is a measurement instrument for subjective characteristics or attitudes that cannot be directly measured.

  Day 7

• Trismus

  Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening.

  Day 1

• Trismus

  Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening.

  Day 2

• Trismus

  Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening.

  Day 3

• Trismus

  Trismus by measuring the distance between the mesial incisal corners of the upper and lower right incisors during maximum mouth opening.

  Day 7

• Swelling

  measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible.

  Day 1

• Swelling

  measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible.

  Day 2

• Swelling

  measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible.

  Day 3

• Swelling

  measured using a flexible plastic measuring tape as described by Gabka and Matsumura by measuring the distance from the corner of the mouth to the attachment of the earlobe following the bulge of the cheek and the distance from the outer canthus of the eye to the angle of the mandible.

  Day 7

Secondary Outcomes (4)

• the number of analgesic tablets

  Day 1

• the number of analgesic tablets

  Day 2

• the number of analgesic tablets

  Day 3

• the number of analgesic tablets

  Day 7

Study Arms (4)

Group 1

platelet rich fibrin placed into the socket of the extraciton tooth + Augmentin 1gr tablet prescribed 2 times a day

Diagnostic Test: Diagnoses; Procedure: traditional osteotomies; Biological: platelet rich fibrin; Drug: Antibiotics, Penicillin; Drug: Analgesic

Group 2

platelet rich fibrin placed in to the socket of the extractraciton tooth combined with low laser treatment extraorally to the extraction area for three days within surgery day + Augmentin 1gr tablet prescribed 2 times a day

Diagnostic Test: Diagnoses; Procedure: traditional osteotomies; Biological: platelet rich fibrin; Drug: Antibiotics, Penicillin; Device: low laser therapy, bicure laser; Drug: Analgesic

Group 3

Low Laser Treatment was applied to the extraorally to the extraction area for three days within surgery day + Augmentin 1gr tablet prescribed 2 times a day

Diagnostic Test: Diagnoses; Procedure: traditional osteotomies; Drug: Antibiotics, Penicillin; Device: low laser therapy, bicure laser; Drug: Analgesic

Control group.

Tradional osteomy was made. + Augmentin 1gr tablet prescribed 2 times a day

Diagnostic Test: Diagnoses; Procedure: traditional osteotomies; Drug: Antibiotics, Penicillin; Drug: Analgesic

Interventions

Diagnoses DIAGNOSTIC_TEST

All of the patients withstand a radiological examination, including panoramic radiography, and all were handled by the same surgeon and assistant.

Control group.; Group 1; Group 2; Group 3

traditional osteotomies PROCEDURE

In all groups the flap incision was triangular in shape which avoids muscle involvement (Archer flap).

Control group.; Group 1; Group 2; Group 3

platelet rich fibrin BIOLOGICAL

Platelet rich fibrin (PRF), is an example and popular procedure for accelerate healing of soft and hard tissue because of the presence of various growth factors.a blood sample was taken without anticoagulant in 10 mL glass-coated plastic tubes that were immediately centrifuged (Elektro-mag M415P) at 3,000 rpm for 10 min (approximately 400 g) (13). The platelet-poor plasma that accumulated at the top of the tubes was discarded.PRF was dissected approximately 2 mm below its contact point with the red corpuscles situated beneath, to include any remaining platelets that may have localized below the junction between the PRF and red corpuscles.

Group 1; Group 2

Antibiotics, Penicillin DRUG

Antibiotics are prescribed for the patients.

Control group.; Group 1; Group 2; Group 3

low laser therapy, bicure laser DEVICE

There are studies in the literature that low-energy lasers have positive effects on the biological and biochemical processes of wound healing. Acceleration of local circulation, increase in cell proliferation and collagen synthesis are among the various effects of laser application. B Cure Dental Pro Laser application will be applied to the patient for the first 3 days. Low dose laser application will be applied to the angulus area, covering the surgical area for 8 minutes. Before this laser procedure, the patient will be asked to fill out a pain scale. This pain scale and the number of analgesics used will be monitored for 3 days.

Group 2; Group 3

Analgesic DRUG

Analgesics are prescribed for the patients.

Control group.; Group 1; Group 2; Group 3

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

community aged between 18-40 without any important systemic disease.

You may qualify if:

• The patient had no systemic diseases, no taken opioids for a long period, no current infections or acute pericoronitis, no smoke or drink alcohol, no pregnancy, the absence of allergy to penicillin and presence of penicillin allergy.

You may not qualify if:

• pericoronitis, no inflammation

Sponsors & Collaborators

• Beste Erismen: lead

Study Sites (1)

Near East University

Nicosia, Lefkosa, 99138, Cyprus

Location

Related Publications (5)

• Desmet KD, Paz DA, Corry JJ, Eells JT, Wong-Riley MT, Henry MM, Buchmann EV, Connelly MP, Dovi JV, Liang HL, Henshel DS, Yeager RL, Millsap DS, Lim J, Gould LJ, Das R, Jett M, Hodgson BD, Margolis D, Whelan HT. Clinical and experimental applications of NIR-LED photobiomodulation. Photomed Laser Surg. 2006 Apr;24(2):121-8. doi: 10.1089/pho.2006.24.121.

  PMID: 16706690 BACKGROUND

• Krynicka I, Rutowski R, Staniszewska-Kus J, Fugiel J, Zaleski A. The role of laser biostimulation in early post-surgery rehabilitation and its effect on wound healing. Ortop Traumatol Rehabil. 2010 Jan-Feb;12(1):67-79.

  PMID: 20203347 BACKGROUND

• Donmezer CM, Bilginaylar K. Comparison of the Postoperative Effects of Local Antibiotic versus Systemic Antibiotic with the Use of Platelet-Rich Fibrin on Impacted Mandibular Third Molar Surgery: A Randomized Split-Mouth Study. Biomed Res Int. 2021 Dec 2;2021:3040661. doi: 10.1155/2021/3040661. eCollection 2021.

  PMID: 34901267 BACKGROUND

• Feslihan E, Eroglu CN. Can Photobiomodulation Therapy Be an Alternative to Methylprednisolone in Reducing Pain, Swelling, and Trismus After Removal of Impacted Third Molars? Photobiomodul Photomed Laser Surg. 2019 Nov;37(11):700-705. doi: 10.1089/photob.2019.4696. Epub 2019 Oct 7.

  PMID: 31589558 BACKGROUND

• Erismen Agan B, Uyanik LO, Donmezer CM. Comparison of the postoperative effect of low laser therapy and platelet rich fibrin on mandibular third molar surgery: a randomized study. BMC Oral Health. 2025 Mar 25;25(1):427. doi: 10.1186/s12903-025-05828-3.

  PMID: 40134000 DERIVED

MeSH Terms

Interventions

Diagnosis; Penicillins; Analgesics

Intervention Hierarchy (Ancestors)

beta-Lactams; Lactams; Amides; Organic Chemicals; Sulfur Compounds; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds; Sensory System Agents; Peripheral Nervous System Agents; Physiological Effects of Drugs; Pharmacologic Actions; Chemical Actions and Uses; Central Nervous System Agents; Therapeutic Uses

Study Officials

• Beste Erismen Agan

  Near East University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Phd Stıdent

Study Record Dates

• First Submitted: February 8, 2024
• First Posted: February 16, 2024
• Study Start: January 2, 2024
• Primary Completion: February 6, 2024
• Study Completion: February 7, 2024
• Last Updated: February 16, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

CY (1)