Assessing the Impact of COVID-19 on HMPV Incidence and Severity Among Adults

NCT06309212 | Completed

• 1 other identifier: 2023-20/687
• Study Type: observational
• Target: 2,197
• Locations: 1 country
• Sites: 1

Brief Summary

Human metapneumovirus (HMPV) is primarily recognized as a childhood pathogen, but its impact on adults remains largely underestimated. This study investigates the prevalence, clinical characteristics, and post-COVID-19 trends of HMPV infection among adults in Istanbul, Turkey.

Conditions

The Prevalance of HMPV After COVID-19 Pandemic; The Importance of Accurate Diagnosis for HPMV

Keywords

Adults; Human metapneumovirus; Post-COVID-19 era; Prevalence; Underestimated Virus

Outcome Measures

Primary Outcomes (1)

• Prevalence of HMPV infection in adults pre- and post-COVID-19 pandemic

  Analyse of data from adults with respiratory tract infections who were tested for various respiratory viruses using a multiplex PCR assay

  Between 2016-2020 (pre-COVID) and 2021-2023 (post-COVID)

Secondary Outcomes (1)

• Comparison of HMPV with other respiratory viruses in adults

  Between 2016-2020 (pre-COVID) and 2021-2023 (post-COVID)

Study Arms (2)

Pre-COVID period

January 2016 to January 2020

Other: Observation

Post-COVID period

January 2021 to September 2023

Other: Observation

Interventions

Observation OTHER

Analyse of data from adults with respiratory tract infections who were tested for various respiratory viruses using a multiplex PCR assay

Post-COVID period; Pre-COVID period

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This retrospective study examined adults with acute respiratory tract infections in Istanbul, Turkey. Patients admitted between 2016-2020 (pre-COVID) and 2021-2023 (post-COVID) underwent multiplex PCR testing for various respiratory viruses, with a focus on human metapneumovirus. The study aimed to assess the prevalence of HMPV infection in adults and its potential change after the COVID-19 pandemic.

You may qualify if:

• Adults \>18 years
• Patients with acute respiratory tract infection symptoms
• Patients who underwent multiplex PCR testing for respiratory viruses

You may not qualify if:

• Patients for whom no respiratory viral panel test was conducted

Sponsors & Collaborators

• Acibadem University: lead

Study Sites (1)

Acibadem University

Istanbul, Turkey (Türkiye)

Location

Related Publications (5)

• Niederman MS, Torres A. Respiratory infections. Eur Respir Rev. 2022 Oct 19;31(166):220150. doi: 10.1183/16000617.0150-2022. Print 2022 Dec 31.

  PMID: 36261160 BACKGROUND

• Haas LE, Thijsen SF, van Elden L, Heemstra KA. Human metapneumovirus in adults. Viruses. 2013 Jan 8;5(1):87-110. doi: 10.3390/v5010087.

  PMID: 23299785 BACKGROUND

• Boivin G, De Serres G, Hamelin ME, Cote S, Argouin M, Tremblay G, Maranda-Aubut R, Sauvageau C, Ouakki M, Boulianne N, Couture C. An outbreak of severe respiratory tract infection due to human metapneumovirus in a long-term care facility. Clin Infect Dis. 2007 May 1;44(9):1152-8. doi: 10.1086/513204. Epub 2007 Mar 28.

  PMID: 17407031 BACKGROUND

• Chow EJ, Uyeki TM, Chu HY. The effects of the COVID-19 pandemic on community respiratory virus activity. Nat Rev Microbiol. 2023 Mar;21(3):195-210. doi: 10.1038/s41579-022-00807-9. Epub 2022 Oct 17.

  PMID: 36253478 BACKGROUND

• Pearson V. Case studies. Baton Rouge puts community first. Trustee. 1995 May;48(5):24-6. No abstract available.

  PMID: 10142898 BACKGROUND

MeSH Terms

Interventions

Observation

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 12, 2024
• First Posted: March 13, 2024
• Study Start: December 15, 2023
• Primary Completion: December 30, 2023
• Study Completion: January 30, 2024
• Last Updated: March 13, 2024

Record last verified: 2024-03

Locations

TU (1)