NCT06307652

Brief Summary

This is a Phase III, international, multi-centre, randomised, double-blind, parallel-group, double-dummy, active-controlled, event-driven study in patients with chronic HF and impaired kidney function who had a recent HF event. The aim is to evaluate the effect of balcinrenone/dapagliflozin vs dapagliflozin, given once daily on top of other classes of SoC, on CV death and HF events.

Trial Health

88
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
4,800

participants targeted

Target at P75+ for phase_3

Timeline
13mo left

Started Apr 2024

Typical duration for phase_3

Geographic Reach
38 countries

834 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress67%
Apr 2024Jun 2027

First Submitted

Initial submission to the registry

February 6, 2024

Completed
1 month until next milestone

First Posted

Study publicly available on registry

March 13, 2024

Completed
1 month until next milestone

Study Start

First participant enrolled

April 12, 2024

Completed
3.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 11, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 11, 2027

Last Updated

April 27, 2026

Status Verified

April 1, 2026

Enrollment Period

3.2 years

First QC Date

February 6, 2024

Last Update Submit

April 24, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Time to first occurrence of any of the components of the composite of: •CV death •HF hospitalisation •HF event without hospitalisation

    To determine whether balcinrenone/dapagliflozin is superior to dapagliflozin in reducing the risk of CV death and HF events with and without hospitalisation

    Approximately 38 months

Secondary Outcomes (5)

  • Total occurrences (first and recurrent) of the components of the composite of: •CV death •HF hospitalisation •HF event without hospitalisation

    Approximately 38 months

  • Total occurrences (first and recurrent) of HF hospitalisations

    Approximately 38 months

  • Time to CV death

    Approximately 38 months

  • The hierarchical composite endpoint of death from any cause, total HF events, and change from baseline in KCCQ total symptom score to 24-week post-randomisation

    Approximately 24 weeks

  • Time to death from any cause

    Approximately 38 months

Study Arms (3)

balcinrenone/dapagliflozin 15 mg/10 mg

EXPERIMENTAL

Patients will be randomized 1:1:1 to either combination of balcinrenone/dapagliflozin and matching placebo for dapagliflozin or dapagliflozin and matching placebo for balcinrenone/dapagliflozin

Drug: balcinrenone/dapagliflozin 15 mg/10 mg and matching placebo for dapagliflozin 10 mg

balcinrenone/dapagliflozin 40 mg/10 mg

EXPERIMENTAL

Patients will be randomized 1:1:1 to either combination of balcinrenone/dapagliflozin and matching placebo for dapagliflozin or dapagliflozin and matching placebo for balcinrenone/dapagliflozin

Drug: balcinrenone/dapagliflozin 40 mg/10 mg and matching placebo for dapagliflozin 10 mg

dapagliflozin 10 mg

ACTIVE COMPARATOR

Patients will be randomized 1:1:1 to either combination of balcinrenone/dapagliflozin and matching placebo for dapagliflozin or dapagliflozin and matching placebo for balcinrenone/dapagliflozin

Drug: dapagliflozin 10 mg and matching placebo for balcinrenone/dapagliflozin

Interventions

1 tablet of dapagliflozin 10 mg and 1 capsule of matching placebo for balcinrenone/dapagliflozin once daily, oral use

dapagliflozin 10 mg

1 capsule of balcinrenone/dapagliflozin 40 mg/10 mg and 1 tablet of matching placebo for dapagliflozin 10 mg once daily, oral use

balcinrenone/dapagliflozin 40 mg/10 mg

1 capsule of balcinrenone/dapagliflozin 15 mg/10 mg and 1 tablet of matching placebo for dapagliflozin 10 mg once daily, oral use

balcinrenone/dapagliflozin 15 mg/10 mg

Eligibility Criteria

Age18 Years - 130 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age ≥ 18 years
  • Documented diagnosis of symptomatic HF (NYHA functional class II-IV)
  • Having had a recent HF event within 6 months (hospitalization or urgent visit)
  • Have a LVEF value from an assessment within the last 12 months
  • Managed with SoC therapy for HF and renal impairment according to local guidelines
  • NT-proBNP must be \>300 pg/mL (\>600 pg/mL if concomitant atrial fibrillation or atrial flutter)
  • Not taking an MRA
  • An eGFR ≥ 20 to \< 60 mL/min/1.73 m2
  • Serum/plasma potassium ≤ 5.0 mmol/L

You may not qualify if:

  • Acute coronary syndrome (unstable angina or myocardial infarction), stroke or transient ischaemic attack within the previous 3 months prior to enrolment or during the screening period
  • Major cardiac surgery, coronary revascularisation or valvular repair or replacement, or implantation of a Cardiac resynchronisation therapy device within 3 months prior to enrolment or during the screening period, or planned to undergo any of these operations
  • History of hypertrophic obstructive cardiomyopathy
  • Complex congenital heart disease or severe uncorrected primary valvular disease
  • Symptomatic bradycardia or second- or third-degree heart block without a pacemaker
  • Systolic BP \< 90 mmHg, or symptomatic hypotension within the past 24 hours
  • Primary pulmonary hypertension, chronic pulmonary embolism, severe pulmonary disease including COPD or exacerbation of COPD requiring invasive mechanical ventilation assistance within 12 months prior to enrolment
  • Type 1 diabetes mellitus
  • Kidney replacement therapy in the past 4 weeks, currently requiring kidney replacement or imminent plan to start kidney replacement therapy
  • Acute or chronic liver disease with severe impairment of liver function, eg, ascites, oesophageal varices, coagulopathy, and encephalopathy
  • Suspected or confirmed COVID-19 infection within the last 4 weeks or hospitalisation for COVID-19 within the last 12 weeks
  • Treatment with strong or moderate CYP3A4 inhibitor or inducer

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (845)

Research Site

Alexander City, Alabama, 35010, United States

RECRUITING

Research Site

Birmingham, Alabama, 35209, United States

WITHDRAWN

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Fairhope, Alabama, 36532, United States

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Huntsville, Alabama, 35801, United States

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Phoenix, Arizona, 85016, United States

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Phoenix, Arizona, 85044, United States

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Little Rock, Arkansas, 72205, United States

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Beverly Hills, California, 90211, United States

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Covina, California, 91723, United States

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Encinitas, California, 92024, United States

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Los Angeles, California, 90073, United States

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Los Angeles, California, 90089, United States

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Newport Beach, California, 92663, United States

TERMINATED

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Orange, California, 92868, United States

WITHDRAWN

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Redding, California, 96001, United States

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San Diego, California, 92123, United States

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San Francisco, California, 94110, United States

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San Francisco, California, 94121, United States

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Santa Ana, California, 92704, United States

WITHDRAWN

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Thousand Oaks, California, 91360, United States

TERMINATED

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Vista, California, 92081, United States

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West Hills, California, 91307, United States

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Aurora, Colorado, 80045, United States

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Wheat Ridge, Colorado, 80033, United States

TERMINATED

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Altamonte Springs, Florida, 32701, United States

TERMINATED

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Boca Raton, Florida, 33486, United States

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Bradenton, Florida, 34209, United States

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Clearwater, Florida, 33756, United States

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Delray Beach, Florida, 33484, United States

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Fort Lauderdale, Florida, 33308, United States

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Gainesville, Florida, 32610, United States

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Jacksonville, Florida, 32209, United States

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Miami, Florida, 33133, United States

TERMINATED

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Miami, Florida, 33176, United States

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Miami Lakes, Florida, 33014, United States

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Palm Beach Gardens, Florida, 33410, United States

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Pensacola, Florida, 32503, United States

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Port Charlotte, Florida, 33952, United States

WITHDRAWN

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Safety Harbor, Florida, 34695, United States

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Saint Augustine, Florida, 32086, United States

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St. Petersburg, Florida, 33701, United States

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Tampa, Florida, 33617, United States

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Atlanta, Georgia, 30303, United States

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Atlanta, Georgia, 30309, United States

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Peachtree City, Georgia, 30269, United States

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Thomasville, Georgia, 31792, United States

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Tucker, Georgia, 30084, United States

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Chicago, Illinois, 60612, United States

WITHDRAWN

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Chicago, Illinois, 60637, United States

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Glenview, Illinois, 60026, United States

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Hazel Crest, Illinois, 60429, United States

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North Chicago, Illinois, 60064, United States

TERMINATED

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Peoria, Illinois, 61614, United States

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Winfield, Illinois, 60190, United States

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Elkhart, Indiana, 46514, United States

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Evansville, Indiana, 47710, United States

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Hammond, Indiana, 46324, United States

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Indianapolis, Indiana, 46237, United States

WITHDRAWN

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Muncie, Indiana, 47303, United States

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Munster, Indiana, 46321, United States

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Richmond, Indiana, 47374, United States

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Waterloo, Iowa, 50701, United States

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Wichita, Kansas, 67218, United States

WITHDRAWN

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Wichita, Kansas, 67226, United States

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Louisville, Kentucky, 40202, United States

TERMINATED

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Alexandria, Louisiana, 71301, United States

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New Orleans, Louisiana, 70121, United States

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Shreveport, Louisiana, 71105, United States

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West Monroe, Louisiana, 71291, United States

RECRUITING

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Augusta, Maine, 04330, United States

WITHDRAWN

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Rockville, Maryland, 20850, United States

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Boston, Massachusetts, 02114, United States

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Fall River, Massachusetts, 02721, United States

WITHDRAWN

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Worcester, Massachusetts, 01655, United States

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Ann Arbor, Michigan, 48109, United States

WITHDRAWN

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Bloomfield Hills, Michigan, 48304, United States

RECRUITING

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Dearborn, Michigan, 48126, United States

TERMINATED

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Farmington Hills, Michigan, 48334, United States

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Flint, Michigan, 48504, United States

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Troy, Michigan, 48098, United States

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Ypsilanti, Michigan, 48197, United States

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Minneapolis, Minnesota, 55455, United States

WITHDRAWN

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Saint Paul, Minnesota, 55109, United States

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Jackson, Mississippi, 39216, United States

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Columbia, Missouri, 65201, United States

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Kansas City, Missouri, 64111, United States

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Kansas City, Missouri, 64128, United States

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Lincoln, Nebraska, 68506, United States

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Lincoln, Nebraska, 68510, United States

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Henderson, Nevada, 89074, United States

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North Las Vegas, Nevada, 89086, United States

WITHDRAWN

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Bridgewater, New Jersey, 08807, United States

WITHDRAWN

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Jersey City, New Jersey, 07302, United States

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Somerset, New Jersey, 08873, United States

RECRUITING

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Albany, New York, 12208, United States

WITHDRAWN

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Brooklyn, New York, 11219, United States

NOT YET RECRUITING

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Brooklyn, New York, 11220, United States

RECRUITING

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Clifton Park, New York, 12065, United States

NOT YET RECRUITING

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Manhasset, New York, 11030, United States

WITHDRAWN

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New Windsor, New York, 12553, United States

WITHDRAWN

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New York, New York, 10029, United States

RECRUITING

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Staten Island, New York, 10310, United States

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Stony Brook, New York, 11794, United States

WITHDRAWN

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The Bronx, New York, 10451, United States

RECRUITING

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The Bronx, New York, 10455, United States

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Asheville, North Carolina, 28801, United States

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Chapel Hill, North Carolina, 27517, United States

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Charlotte, North Carolina, 28204, United States

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Durham, North Carolina, 27710, United States

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Greensboro, North Carolina, 27405, United States

WITHDRAWN

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Pinehurst, North Carolina, 28374, United States

RECRUITING

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Statesville, North Carolina, 28625, United States

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Wilmington, North Carolina, 28401, United States

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Cincinnati, Ohio, 45219, United States

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Cincinnati, Ohio, 45267, United States

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Dayton, Ohio, 45414, United States

RECRUITING

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Maumee, Ohio, 43537, United States

WITHDRAWN

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Springfield, Ohio, 45504, United States

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Oklahoma City, Oklahoma, 73102, United States

WITHDRAWN

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Portland, Oregon, 97225, United States

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Abington, Pennsylvania, 19001, United States

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Camp Hill, Pennsylvania, 17011, United States

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Hershey, Pennsylvania, 17033, United States

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Horsham, Pennsylvania, 19044, United States

TERMINATED

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Philadelphia, Pennsylvania, 19104, United States

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Providence, Rhode Island, 02908, United States

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Anderson, South Carolina, 29621, United States

TERMINATED

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Charleston, South Carolina, 29401, United States

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Charleston, South Carolina, 29425, United States

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Ladson, South Carolina, 29456, United States

WITHDRAWN

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Lancaster, South Carolina, 29720, United States

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Rapid City, South Dakota, 57701, United States

RECRUITING

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Jackson, Tennessee, 38305, United States

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Knoxville, Tennessee, 37916, United States

RECRUITING

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Memphis, Tennessee, 38120, United States

RECRUITING

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Memphis, Tennessee, 38128, United States

TERMINATED

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Nashville, Tennessee, 37212, United States

RECRUITING

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Tullahoma, Tennessee, 37388, United States

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Allen, Texas, 75013, United States

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Amarillo, Texas, 79106, United States

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Amarillo, Texas, 79121, United States

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Cypress, Texas, 77429, United States

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Dallas, Texas, 75204, United States

RECRUITING

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Dallas, Texas, 75216, United States

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Dallas, Texas, 75390, United States

RECRUITING

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El Paso, Texas, 79905, United States

RECRUITING

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Houston, Texas, 77002, United States

TERMINATED

Research Site

Houston, Texas, 77025, United States

RECRUITING

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Katy, Texas, 77493, United States

TERMINATED

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Mansfield, Texas, 76063, United States

TERMINATED

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McKinney, Texas, 75069, United States

RECRUITING

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McKinney, Texas, 75071, United States

RECRUITING

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Odessa, Texas, 79761, United States

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Research Site

Pearland, Texas, 77584, United States

SUSPENDED

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San Antonio, Texas, 78229, United States

RECRUITING

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Sherman, Texas, 75092, United States

TERMINATED

Research Site

Temple, Texas, 76508, United States

RECRUITING

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Tyler, Texas, 75701, United States

RECRUITING

Research Site

Tyler, Texas, 75702, United States

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Salt Lake City, Utah, 84107, United States

WITHDRAWN

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Salt Lake City, Utah, 84148, United States

RECRUITING

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Falls Church, Virginia, 22042, United States

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Newport News, Virginia, 23606, United States

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Puyallup, Washington, 98372, United States

WITHDRAWN

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Seattle, Washington, 98101, United States

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Tacoma, Washington, 98405, United States

WITHDRAWN

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Buenos Aires, 1416, Argentina

RECRUITING

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Buenos Aires, C1056ABJ, Argentina

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Buenos Aires, C1180AAX, Argentina

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CABA, C1425AGC, Argentina

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Ciudad de Buenos Aires, 1425DES, Argentina

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Ciudad de Buenos Aires, C1419AHL, Argentina

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Corrientes, W3400CDS, Argentina

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Córdoba, X5003DCE, Argentina

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Córdoba, X5006CBI, Argentina

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Esperanza, S3080BQU, Argentina

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Granadero Baigorria, S2152BOF, Argentina

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Mar del Plata, B7600GNY, Argentina

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Rosario, 2123, Argentina

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San Juan Bautista, 1888, Argentina

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San Miguel de Tucumán, 4000, Argentina

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San Miguel de Tucumán, 4000, Argentina

WITHDRAWN

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San Miguel de Tucumán, T4000ICL, Argentina

RECRUITING

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Santa Fe, S3000FWO, Argentina

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Blacktown, 2148, Australia

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Cairns, 4870, Australia

WITHDRAWN

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Canberra, 2605, Australia

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Chermside, 4032, Australia

WITHDRAWN

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Clayton, 3168, Australia

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Concord, 2139, Australia

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Frankston, 3199, Australia

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Geelong, 3220, Australia

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Murdoch, WA6150, Australia

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North Tamworth, 2340, Australia

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Westmead, 2145, Australia

NOT YET RECRUITING

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Bad Ischl, 4820, Austria

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Braunau am Inn, 5280, Austria

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Graz, 8036, Austria

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Linz, 4020, Austria

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Saint Stefan/Stainz, 8511, Austria

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Salzburg, 5020, Austria

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Sankt Pölten, 3100, Austria

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Vienna, 1090, Austria

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Vienna, 1100, Austria

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Vienna, 1160, Austria

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Vöcklabruck, 4840, Austria

NOT YET RECRUITING

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Aracaju, 49015-380, Brazil

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Blumenau, 89020-430, Brazil

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Brasília, 70200-730, Brazil

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Campina Grande do Sul, 83.430-000, Brazil

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Campinas, 13060-080, Brazil

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Curitiba, 80730-150, Brazil

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Goiânia, 74605-020, Brazil

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Niterói, 24033-900, Brazil

NOT YET RECRUITING

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Porto Alegre, 90035-903, Brazil

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Rio Branco, 69915-030, Brazil

NOT YET RECRUITING

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Rio de Janeiro, 20241-180, Brazil

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Rio de Janeiro, 20551-030, Brazil

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Rio de Janeiro, 22061-080, Brazil

WITHDRAWN

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São José dos Campos, 12230-001, Brazil

RECRUITING

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São Paulo, 04012-180, Brazil

SUSPENDED

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São Paulo, 05403-000, Brazil

WITHDRAWN

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Teresina, 64049-550, Brazil

RECRUITING

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Uberlândia, 38400-500, Brazil

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Botevgrad, 2140, Bulgaria

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Dupnitsa, 2600, Bulgaria

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Haskovo, 6300, Bulgaria

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Kozloduy, 3320, Bulgaria

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Pleven, 5800, Bulgaria

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Plovdiv, 4000, Bulgaria

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Plovdiv, 4003, Bulgaria

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Sliven, 8800, Bulgaria

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Sliven, 8800, Bulgaria

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Sofia, 1000, Bulgaria

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Sofia, 1309, Bulgaria

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Sofia, 1431, Bulgaria

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Sofia, 1606, Bulgaria

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Sofia, 1618, Bulgaria

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Sofia, 1756, Bulgaria

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Stara Zagora, 6000, Bulgaria

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New Westminster, British Columbia, V3L 3W4, Canada

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North Vancouver, British Columbia, V7M 2H4, Canada

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Vancouver, British Columbia, V6Z 1Y6, Canada

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Winnipeg, Manitoba, R2H 2A6, Canada

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Sydney, Nova Scotia, B1P 1P3, Canada

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Cambridge, Ontario, N1R 6V6, Canada

COMPLETED

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Cambridge, Ontario, N1R 7R1, Canada

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Hamilton, Ontario, L8L 5G4, Canada

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London, Ontario, N6A 5A5, Canada

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Newmarket, Ontario, L3Y 2P6, Canada

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North York, Ontario, M6B 3H7, Canada

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Oakville, Ontario, L6K 3W7, Canada

WITHDRAWN

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Oshawa, Ontario, L1J 2K1, Canada

TERMINATED

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Ottawa, Ontario, K1Y 4W7, Canada

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Peterborough, Ontario, K9J 0B2, Canada

WITHDRAWN

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Thunder Bay, Ontario, P7B 7C7, Canada

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Toronto, Ontario, M6G 1M2, Canada

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Waterloo, Ontario, N2T 0C1, Canada

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Chicoutimi, Quebec, G7H 7K9, Canada

WITHDRAWN

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Greenfield Park, Quebec, J4V 2H1, Canada

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Montreal, Quebec, H1T 1C8, Canada

RECRUITING

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Montreal, Quebec, H2X 0C1, Canada

RECRUITING

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Montreal, Quebec, H3G 1A4, Canada

WITHDRAWN

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Montreal, Quebec, H4J 1C5, Canada

RECRUITING

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Saint-Charles-Borromée, Quebec, J6E 2B4, Canada

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Saint-Jean-sur-Richelieu, Quebec, J3A 1J2, Canada

WITHDRAWN

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Trois-Rivières, Quebec, G9A 4P3, Canada

RECRUITING

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Antofagasta, 1240000, Chile

WITHDRAWN

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Punta Arenas, 6200000, Chile

WITHDRAWN

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Region Metropolitana, 7550000, Chile

RECRUITING

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San Bernardo, 8070996, Chile

RECRUITING

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Santiago, 7500587, Chile

WITHDRAWN

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Santiago, 7500922, Chile

TERMINATED

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Santiago, 7770086, Chile

WITHDRAWN

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Santiago, 8330034, Chile

TERMINATED

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Santiago, 8380453, Chile

RECRUITING

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Santiago, 8910259, Chile

RECRUITING

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Talcahuano, 4270918, Chile

NOT YET RECRUITING

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Temuco, 4781156, Chile

WITHDRAWN

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Temuco, 4810345, Chile

RECRUITING

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Valdivia, 5110683, Chile

RECRUITING

Research Site

Victoria, 4720097, Chile

RECRUITING

Research Site

Baotou, 14010, China

RECRUITING

Research Site

Beijing, 100029, China

WITHDRAWN

Research Site

Beijing, 100029, China

TERMINATED

Research Site

Beijing, 100034, China

RECRUITING

Research Site

Beijing, 100037, China

RECRUITING

Research Site

Beijing, 100730, China

RECRUITING

Research Site

Changchun, 130033, China

RECRUITING

Research Site

Changsha, 410015, China

RECRUITING

Research Site

Changsha, 430033, China

RECRUITING

Research Site

Chengdu, 610041, China

RECRUITING

Research Site

Chengdu, 610072, China

RECRUITING

Research Site

Chifeng, 024000, China

RECRUITING

Research Site

Chongqing, 404197, China

RECRUITING

Research Site

Guangzhou, 510100, China

RECRUITING

Research Site

Guangzhou, 510515, China

RECRUITING

Research Site

Guangzhou, 510630, China

RECRUITING

Research Site

Hangzhou, 310014, China

RECRUITING

Research Site

Harbin, 150001, China

RECRUITING

Research Site

Hengyang, 421001, China

RECRUITING

Research Site

Heze, 274099, China

RECRUITING

Research Site

Hohhot, 010017, China

WITHDRAWN

Research Site

Jinan, 250013, China

RECRUITING

Research Site

Jining, 272029, China

RECRUITING

Research Site

Lanzhou, 730030, China

RECRUITING

Research Site

Liaocheng, 252000, China

RECRUITING

Research Site

Linhai, 317000, China

RECRUITING

Research Site

Nanchang, 330009, China

RECRUITING

Research Site

Nanchong, 637900, China

COMPLETED

Research Site

Nanjing, 2100008, China

RECRUITING

Research Site

Nanjing, 210009, China

RECRUITING

Research Site

Nanjing, 210011, China

RECRUITING

Research Site

Nanjing, 210029, China

RECRUITING

Research Site

Ningbo, 315040, China

RECRUITING

Research Site

Pingxiang, 337055, China

RECRUITING

Research Site

Quzhou, 342000, China

RECRUITING

Research Site

Sanya, 572000, China

RECRUITING

Research Site

Shanghai, 200025, China

RECRUITING

Research Site

Shanghai, 200062, China

RECRUITING

Research Site

Shenyang, 110004, China

RECRUITING

Research Site

Shenzhen, 518053, China

RECRUITING

Research Site

Ürümqi, CN-830004, China

RECRUITING

Research Site

Wuhan, 430022, China

WITHDRAWN

Research Site

Wuhan, 430030, China

WITHDRAWN

Research Site

Xi'an, 710061, China

RECRUITING

Research Site

Xi'an, 710068, China

RECRUITING

Research Site

Xianyang, 750004, China

WITHDRAWN

Research Site

Xuzhou, 221000, China

RECRUITING

Research Site

Xuzhou, 221009, China

RECRUITING

Research Site

Yangzhou, 225001, China

RECRUITING

Research Site

Zhangjiakou, 075061, China

RECRUITING

Research Site

Zunyi, 563100, China

RECRUITING

Research Site

Armenia, 630004, Colombia

RECRUITING

Research Site

Barranquilla, 080020, Colombia

RECRUITING

Research Site

Barranquilla, 80007, Colombia

RECRUITING

Research Site

Bogotá, 110221, Colombia

COMPLETED

Research Site

Bogotá, 111211, Colombia

RECRUITING

Research Site

Cali, 760032, Colombia

RECRUITING

Research Site

Cali, 760036, Colombia

RECRUITING

Research Site

Manizales, 170004, Colombia

RECRUITING

Research Site

Medellín, 050030, Colombia

RECRUITING

Research Site

Medellín, 050034, Colombia

RECRUITING

Research Site

Piedecuesta, 681017, Colombia

RECRUITING

Research Site

Rionegro, 054047, Colombia

RECRUITING

Research Site

Brno, 60200, Czechia

RECRUITING

Research Site

Brno, 639 00, Czechia

TERMINATED

Research Site

Broumov, 55001, Czechia

RECRUITING

Research Site

Česká Lípa, 470 77, Czechia

RECRUITING

Research Site

Jaroměř, 551 01, Czechia

RECRUITING

Research Site

Louny, 440 01, Czechia

RECRUITING

Research Site

Ostrava, 702 00, Czechia

RECRUITING

Research Site

Ostrava, 702 00, Czechia

SUSPENDED

Research Site

Pilsen, 31001, Czechia

WITHDRAWN

Research Site

Plzen - Bory, 305 99, Czechia

RECRUITING

Research Site

Prague, 120 00, Czechia

TERMINATED

Research Site

Přerov, 75152, Czechia

RECRUITING

Research Site

Slaný, 274 01, Czechia

RECRUITING

Research Site

Svitavy, 568 02, Czechia

RECRUITING

Research Site

Ustí Nad Labem, 40011, Czechia

WITHDRAWN

Research Site

Ústí nad Labem, 400 01, Czechia

RECRUITING

Research Site

Zlín, 760 01, Czechia

RECRUITING

Research Site

Helsinki, 00290, Finland

RECRUITING

Research Site

Tampere, 33520, Finland

RECRUITING

Research Site

Turku, 20520, Finland

RECRUITING

Research Site

Béziers, 34500, France

RECRUITING

Research Site

Bron, 69667, France

WITHDRAWN

Research Site

Caen, 14033, France

WITHDRAWN

Research Site

Cholet, 49300, France

RECRUITING

Research Site

Créteil, 94010, France

RECRUITING

Research Site

Dijon, 21079, France

RECRUITING

Research Site

La Roche-sur-Yon, 85925, France

RECRUITING

Research Site

La Tronche, 38043, France

WITHDRAWN

Research Site

Le Coudray, 28630, France

WITHDRAWN

Research Site

Limoges, 87000, France

RECRUITING

Research Site

Meaux, 77104, France

RECRUITING

Research Site

Montauban, 82017, France

WITHDRAWN

Research Site

Montpellier, 34000, France

RECRUITING

Research Site

Montpellier, 34295, France

RECRUITING

Research Site

Nantes, 44093, France

RECRUITING

Research Site

Orléans, 45100, France

WITHDRAWN

Research Site

Paris, 75010, France

RECRUITING

Research Site

Paris, 75015, France

RECRUITING

Research Site

Poitiers, 86021, France

RECRUITING

Research Site

Reims, 51092, France

RECRUITING

Research Site

Rennes, 35033, France

RECRUITING

Research Site

Rouen, 76031, France

RECRUITING

Research Site

Saint-Quentin, 02100, France

RECRUITING

Research Site

Strasbourg, 67091, France

WITHDRAWN

Research Site

Toulon, 83100, France

RECRUITING

Research Site

Toulouse, 31059, France

RECRUITING

Research Site

Tours, 37044, France

WITHDRAWN

Research Site

Valenciennes, 59300, France

RECRUITING

Research Site

Bad Nauheim, 61231, Germany

SUSPENDED

Research Site

Bechhofen, 66894, Germany

WITHDRAWN

Research Site

Berlin, 12203, Germany

NOT YET RECRUITING

Research Site

Berlin, 13405, Germany

RECRUITING

Research Site

Bernau bei Berlin, 16321, Germany

SUSPENDED

Research Site

Chemnitz, 9113, Germany

WITHDRAWN

Research Site

Coburg, 96450, Germany

RECRUITING

Research Site

Dresden, 01099, Germany

WITHDRAWN

Research Site

Dresden, 1307, Germany

RECRUITING

Research Site

Elsterwerda, 04910, Germany

SUSPENDED

Research Site

Frankfurt, 60590, Germany

WITHDRAWN

Research Site

Freiburg im Breisgau, 79106, Germany

RECRUITING

Research Site

Goslar, 38642, Germany

NOT YET RECRUITING

Research Site

Göttingen, 37075, Germany

NOT YET RECRUITING

Research Site

Hagen, 58135, Germany

RECRUITING

Research Site

Hamburg, 20246, Germany

RECRUITING

Research Site

Hamburg, 22457, Germany

WITHDRAWN

Research Site

Hamburg, 22459, Germany

WITHDRAWN

Research Site

Heidelberg, 69120, Germany

RECRUITING

Research Site

Kaiserslautern, 67655, Germany

WITHDRAWN

Research Site

Langen, 63225, Germany

WITHDRAWN

Research Site

Leipzig, 04103, Germany

SUSPENDED

Research Site

Leverkusen, 51375, Germany

WITHDRAWN

Research Site

Mainz, 55122, Germany

RECRUITING

Research Site

Mainz, 55131, Germany

WITHDRAWN

Research Site

Mönchengladbach, 41063, Germany

SUSPENDED

Research Site

Münster, 48149, Germany

WITHDRAWN

Research Site

Paderborn, 33098, Germany

WITHDRAWN

Research Site

Papenburg, 26871, Germany

RECRUITING

Research Site

Regensburg, 93053, Germany

RECRUITING

Research Site

Rostock, 18059, Germany

WITHDRAWN

Research Site

Völklingen, 66333, Germany

WITHDRAWN

Research Site

Wermsdorf, 04779, Germany

SUSPENDED

Research Site

Witten, 58455, Germany

WITHDRAWN

Research Site

Athens, 11521, Greece

RECRUITING

Research Site

Athens, 11526, Greece

RECRUITING

Research Site

Athens, 11527, Greece

RECRUITING

Research Site

Athens, 11528, Greece

RECRUITING

Research Site

Athens, 12462, Greece

RECRUITING

Research Site

Athens, 14233, Greece

RECRUITING

Research Site

Athens, 15123, Greece

RECRUITING

Research Site

Dragana, 68100, Greece

RECRUITING

Research Site

Heraklio, 71110, Greece

COMPLETED

Research Site

Thessaloniki, 54636, Greece

RECRUITING

Research Site

Thessaloniki, 54642, Greece

RECRUITING

Research Site

Balatonfüred, 8230, Hungary

RECRUITING

Research Site

Békéscsaba, 5600, Hungary

RECRUITING

Research Site

Budapest, 1033, Hungary

RECRUITING

Research Site

Budapest, 1036, Hungary

RECRUITING

Research Site

Budapest, 1122, Hungary

RECRUITING

Research Site

Budapest, 1145, Hungary

WITHDRAWN

Research Site

Gyula, 5700, Hungary

WITHDRAWN

Research Site

Hódmezővásárhely, 6800, Hungary

WITHDRAWN

Research Site

Kecskemét, 6000, Hungary

RECRUITING

Research Site

Orosháza, 5900, Hungary

WITHDRAWN

Research Site

Pécs, 7623, Hungary

RECRUITING

Research Site

Pécs, 7635, Hungary

RECRUITING

Research Site

Székesfehérvár, 8000, Hungary

RECRUITING

Research Site

Ahmedabad, 380054, India

WITHDRAWN

Research Site

Ajmer, 305001, India

WITHDRAWN

Research Site

Amritsar, 143501, India

NOT YET RECRUITING

Research Site

Bangalore, 560099, India

RECRUITING

Research Site

Belagavi, 590010, India

RECRUITING

Research Site

Coimbatore, 641018, India

RECRUITING

Research Site

Dehradun, 248001, India

RECRUITING

Research Site

Delhi, 110062, India

RECRUITING

Research Site

Hyderabad, 500018, India

WITHDRAWN

Research Site

Hyderabad, 500034, India

SUSPENDED

Research Site

Hyderabad, 500035, India

RECRUITING

Research Site

Kanpur, 208001, India

RECRUITING

Research Site

Karamsad, 388345, India

WITHDRAWN

Research Site

Kolkata, 700014, India

RECRUITING

Research Site

Kolkata, 700020, India

RECRUITING

Research Site

Manipal, 576104, India

SUSPENDED

Research Site

Meerut, 250005, India

RECRUITING

Research Site

Mysuru, 570015, India

WITHDRAWN

Research Site

Nagpur, 441108, India

WITHDRAWN

Research Site

New Delhi, 110002, India

RECRUITING

Research Site

New Delhi, 110017, India

RECRUITING

Research Site

New Delhi, 110029, India

RECRUITING

Research Site

Pune, 411001, India

WITHDRAWN

Research Site

Rudrapur, 263153, India

RECRUITING

Research Site

Vijayawada, 520 008, India

SUSPENDED

Research Site

Afula, 1834111, Israel

RECRUITING

Research Site

Ashkelon, 78278, Israel

RECRUITING

Research Site

Beersheba, 8410101, Israel

RECRUITING

Research Site

Be’er Ya‘aqov, 70300, Israel

RECRUITING

Research Site

Haifa, 3109601, Israel

RECRUITING

Research Site

Holon, 5840608, Israel

RECRUITING

Research Site

Jerusalem, 00000, Israel

RECRUITING

Research Site

Kfar Saba, 4428164, Israel

RECRUITING

Research Site

Nahariya, 22100, Israel

RECRUITING

Research Site

Petah Tikva, 49372, Israel

RECRUITING

Research Site

Tel Aviv, 6423906, Israel

RECRUITING

Research Site

Tiberias, 15208, Israel

RECRUITING

Research Site

Acquaviva delle Fonti, 70021, Italy

WITHDRAWN

Research Site

Bari, 70124, Italy

RECRUITING

Research Site

Bergamo, 24127, Italy

RECRUITING

Research Site

Brescia, 25100, Italy

RECRUITING

Research Site

Catania, 95100, Italy

RECRUITING

Research Site

Catanzaro, 88100, Italy

RECRUITING

Research Site

Cona, 44124, Italy

RECRUITING

Research Site

Cortona, 52044, Italy

RECRUITING

Research Site

Florence, 50134, Italy

WITHDRAWN

Research Site

Milan, 20138, Italy

RECRUITING

Research Site

Novara, 28100, Italy

WITHDRAWN

Research Site

Pavia, 27100, Italy

RECRUITING

Research Site

San Giovanni Rotondo, 71013, Italy

WITHDRAWN

Research Site

Beppu-shi, 874-0011, Japan

RECRUITING

Research Site

Bunkyō City, 113-8431, Japan

RECRUITING

Research Site

Fujisawa-shi, 251-8550, Japan

RECRUITING

Research Site

Fukui-shi, 910-8526, Japan

RECRUITING

Research Site

Fukuoka, 810-8563, Japan

RECRUITING

Research Site

Fukuoka, 812-8582, Japan

RECRUITING

Research Site

Fukuoka, 815-8555, Japan

RECRUITING

Research Site

Fukutsu-shi, 811-3298, Japan

RECRUITING

Research Site

Hakusan-shi, 924-8588, Japan

RECRUITING

Research Site

Higashiibaraki-gun, 311-3193, Japan

RECRUITING

Research Site

Himeji, 670-8560, Japan

RECRUITING

Research Site

Iwakuni-shi, 740-8510, Japan

RECRUITING

Research Site

Kanazawa, 920-8530, Japan

RECRUITING

Research Site

Kanazawa, 920-8650, Japan

WITHDRAWN

Research Site

Kanonji-shi, 769-1695, Japan

RECRUITING

Research Site

Kasuga-shi, 816-0864, Japan

SUSPENDED

Research Site

Kasugai-shi, 486-8510, Japan

RECRUITING

Research Site

Kawaguchi, 333-0842, Japan

RECRUITING

Research Site

Kawanishi-shi, 666-0125, Japan

RECRUITING

Research Site

Kishiwada-shi, 596-8522, Japan

RECRUITING

Research Site

Kitakyusyu-shi, 806-8501, Japan

SUSPENDED

Research Site

Kobe, 654-0155, Japan

RECRUITING

Research Site

Kochi, 780-8535, Japan

RECRUITING

Research Site

Kure-shi, 737-8505, Japan

RECRUITING

Research Site

Maebashi, 371-8511, Japan

RECRUITING

Research Site

Matsumoto-shi, 390-8621, Japan

RECRUITING

Research Site

Meguro-ku, 152-8902, Japan

RECRUITING

Research Site

Mito, 311-4198, Japan

RECRUITING

Research Site

Moriyama-shi, 524-8524, Japan

RECRUITING

Research Site

Nagoya, 460-0001, Japan

SUSPENDED

Research Site

Osaka, 540-0006, Japan

RECRUITING

Research Site

Osaka, 543-0035, Japan

RECRUITING

Research Site

Ōita, 870-8511, Japan

RECRUITING

Research Site

Sagamihara-shi, 252-5188, Japan

RECRUITING

Research Site

Saitama Shi, 336 8522, Japan

RECRUITING

Research Site

Saitama-shi, 339-0033, Japan

WITHDRAWN

Research Site

Sakaishi, 599-8247, Japan

RECRUITING

Research Site

Sakata, 998-8501, Japan

SUSPENDED

Research Site

Sanyoonoda-shi, 756-0095, Japan

RECRUITING

Research Site

Toshima-ku, 171-0014, Japan

RECRUITING

Research Site

Toyota, 470-0396, Japan

RECRUITING

Research Site

Tsuchiura-shi, 300-0028, Japan

TERMINATED

Research Site

Ueda-shi, 386-8610, Japan

RECRUITING

Research Site

Uji-shi, 611-0041, Japan

RECRUITING

Research Site

Uwajima-shi, 798-8510, Japan

RECRUITING

Research Site

Yanagawa-shi, 832-0077, Japan

RECRUITING

Research Site

Yokohama, 221-0855, Japan

RECRUITING

Research Site

Yokohama, 227-8501, Japan

WITHDRAWN

Research Site

Yokohama, 245-8575, Japan

WITHDRAWN

Research Site

Kajang, 43000, Malaysia

RECRUITING

Research Site

Kota Kinabalu, 88300, Malaysia

RECRUITING

Research Site

Kota Samarahan, 94300, Malaysia

RECRUITING

Research Site

Kuala Lumpur, 50400, Malaysia

RECRUITING

Research Site

Kuala Terengganu, 20400, Malaysia

RECRUITING

Research Site

Kuantan, 25200, Malaysia

RECRUITING

Research Site

Sungai Buloh, 47000, Malaysia

RECRUITING

Research Site

Aguascalientes, 20230, Mexico

RECRUITING

Research Site

Aguascalientes, 20230, Mexico

NOT YET RECRUITING

Research Site

Chihuahua City, 31203, Mexico

RECRUITING

Research Site

Cuauhtémoc, 06700, Mexico

RECRUITING

Research Site

Cuauhtémoc, 6720, Mexico

NOT YET RECRUITING

Research Site

Culiacán, 80200, Mexico

RECRUITING

Research Site

Culiacán, 80230, Mexico

RECRUITING

Research Site

Guadalajara, 44670, Mexico

RECRUITING

Research Site

Mazatlán, 82110, Mexico

NOT YET RECRUITING

Research Site

Metepec, 52170, Mexico

RECRUITING

Research Site

Mexico City, 03310, Mexico

WITHDRAWN

Research Site

Mexico City, 07300, Mexico

NOT YET RECRUITING

Research Site

México, 07020, Mexico

RECRUITING

Research Site

México, 11650, Mexico

WITHDRAWN

Research Site

México, 14080, Mexico

NOT YET RECRUITING

Research Site

Monterrey, 64060, Mexico

NOT YET RECRUITING

Research Site

Monterrey, 64460, Mexico

NOT YET RECRUITING

Research Site

Morelia, 58260, Mexico

WITHDRAWN

Research Site

Querétaro, 76000, Mexico

RECRUITING

Research Site

San Luis Potosí City, 78250, Mexico

WITHDRAWN

Research Site

Tijuana, 22150, Mexico

RECRUITING

Research Site

Torreón, 27000, Mexico

RECRUITING

Research Site

Veracruz, 91910, Mexico

NOT YET RECRUITING

Research Site

Xalapa, 91193, Mexico

RECRUITING

Research Site

Amsterdam, 1091 AC, Netherlands

RECRUITING

Research Site

Arnhem, 6815 AD, Netherlands

RECRUITING

Research Site

Emmen, 7824 AA, Netherlands

RECRUITING

Research Site

Goes, 4462 RA, Netherlands

RECRUITING

Research Site

Hardenberg, 7772 SE, Netherlands

RECRUITING

Research Site

Leeuwarden, 8934 AD, Netherlands

RECRUITING

Research Site

Bellavista, CALLAO 2, Peru

RECRUITING

Research Site

Cusco, CUSCO 01, Peru

NOT YET RECRUITING

Research Site

Lima, 15024, Peru

RECRUITING

Research Site

Lima, 15046, Peru

WITHDRAWN

Research Site

Lima, 15046, Peru

RECRUITING

Research Site

Lima, 15072, Peru

NOT YET RECRUITING

Research Site

Lima, 15088, Peru

RECRUITING

Research Site

Lima, 15102, Peru

NOT YET RECRUITING

Research Site

Lima, 15131, Peru

WITHDRAWN

Research Site

Lima, L18, Peru

WITHDRAWN

Research Site

Lima, LIMA 11, Peru

RECRUITING

Research Site

Lima, LIMA 27, Peru

RECRUITING

Research Site

Lima, LIMA 41, Peru

RECRUITING

Research Site

Piura, 20001, Peru

RECRUITING

Research Site

Angeles City, 2009, Philippines

RECRUITING

Research Site

Cebu City, 6000, Philippines

WITHDRAWN

Research Site

Cebu City, 6000, Philippines

RECRUITING

Research Site

City of Taguig, 1634, Philippines

RECRUITING

Research Site

Davao City, 8000, Philippines

RECRUITING

Research Site

Davao City, PH-8000, Philippines

NOT YET RECRUITING

Research Site

Davao City, PH-8000, Philippines

RECRUITING

Research Site

Iloilo City, 5000, Philippines

RECRUITING

Research Site

Las Piñas, PH-1704, Philippines

RECRUITING

Research Site

Mabalacat, 2023, Philippines

RECRUITING

Research Site

Makati, 1209, Philippines

RECRUITING

Research Site

Manadaluyong City, 1552, Philippines

RECRUITING

Research Site

Manila, 1008, Philippines

WITHDRAWN

Research Site

Marikina City, 1800, Philippines

RECRUITING

Research Site

Pasig, 1605, Philippines

RECRUITING

Research Site

Quezon City, 1101, Philippines

RECRUITING

Research Site

Quezon City, 1112, Philippines

RECRUITING

Research Site

Quezon City, Philippines

RECRUITING

Research Site

Roxas City, 5800, Philippines

RECRUITING

Research Site

West San Juan City, 1502, Philippines

RECRUITING

Research Site

Biała Podlaska, 21-500, Poland

SUSPENDED

Research Site

Bielsko-Biala, 43-316, Poland

WITHDRAWN

Research Site

Bydgoszcz, 85-605, Poland

WITHDRAWN

Research Site

Bydgoszcz, 85-794, Poland

TERMINATED

Research Site

Chrzanów, 32-500, Poland

RECRUITING

Research Site

Gdansk, 80-214, Poland

RECRUITING

Research Site

Gdansk, 80-462, Poland

RECRUITING

Research Site

Gdynia, 81-157, Poland

WITHDRAWN

Research Site

Katowice, 40-600, Poland

RECRUITING

Research Site

Kazimierza Wielka, 28-500, Poland

RECRUITING

Research Site

Kędzierzyn-Koźle, 47-200, Poland

RECRUITING

Research Site

Krakow, 30-082, Poland

RECRUITING

Research Site

Krakow, 30-688, Poland

RECRUITING

Research Site

Krakow, 31-121, Poland

RECRUITING

Research Site

Krakow, 31-322, Poland

RECRUITING

Research Site

Krakow, 31-513, Poland

WITHDRAWN

Research Site

Lodz, 90-549, Poland

RECRUITING

Research Site

Lodz, 91-053, Poland

WITHDRAWN

Research Site

Lodz, 93-513, Poland

RECRUITING

Research Site

Lodz, 94-046, Poland

SUSPENDED

Research Site

Lublin, 20-044, Poland

COMPLETED

Research Site

Lublin, 20-068, Poland

RECRUITING

Research Site

Lublin, 20-857, Poland

RECRUITING

Research Site

Olsztyn, 10-165, Poland

RECRUITING

Research Site

Ostrów Mazowiecka, 07-300, Poland

RECRUITING

Research Site

Piekary Śląskie, 41-940, Poland

RECRUITING

Research Site

Poznan, 60-266, Poland

RECRUITING

Research Site

Poznan, 61- 848, Poland

RECRUITING

Research Site

Rzeszów, 35-055, Poland

WITHDRAWN

Research Site

Rzeszów, 35-205, Poland

RECRUITING

Research Site

Szczecin, 71-526, Poland

RECRUITING

Research Site

Tarnów, 33-100, Poland

RECRUITING

Research Site

Torun, 87-100, Poland

RECRUITING

Research Site

Tychy, 43-100, Poland

RECRUITING

Research Site

Warsaw, 00-124, Poland

RECRUITING

Research Site

Warsaw, 00-416, Poland

WITHDRAWN

Research Site

Warsaw, 04-501, Poland

WITHDRAWN

Research Site

Wroclaw, 53-602, Poland

WITHDRAWN

Research Site

Wroclaw, 53-605, Poland

RECRUITING

Research Site

Zabrze, 41-800, Poland

RECRUITING

Research Site

Afumaţi, 077010, Romania

RECRUITING

Research Site

Arad, 310037, Romania

RECRUITING

Research Site

Baia Mare, 430222, Romania

RECRUITING

Research Site

Brasov, 500102, Romania

RECRUITING

Research Site

Brasov, 500388, Romania

RECRUITING

Research Site

Bucharest, 010825, Romania

NOT YET RECRUITING

Research Site

Bucharest, 014461, Romania

TERMINATED

Research Site

Bucharest, 014461, Romania

RECRUITING

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Bucharest, 022328, Romania

RECRUITING

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Bucharest, 040883, Romania

WITHDRAWN

Research Site

Cluj-Napoca, 400437, Romania

TERMINATED

Research Site

Iași, 700010, Romania

SUSPENDED

Research Site

Iași, 700503, Romania

RECRUITING

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Satu Mare, 440192, Romania

RECRUITING

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Târgu Mureş, 540099, Romania

RECRUITING

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Târgu Mureş, 540136, Romania

RECRUITING

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Timișoara, 300254, Romania

RECRUITING

Research Site

Timișoara, 300310, Romania

TERMINATED

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Dammam, 31463, Saudi Arabia

NOT YET RECRUITING

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Jeddah, 22384, Saudi Arabia

RECRUITING

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Riyadh, 11426, Saudi Arabia

RECRUITING

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Riyadh, 11462, Saudi Arabia

RECRUITING

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Riyadh, 11481, Saudi Arabia

NOT YET RECRUITING

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Riyadh, 11525, Saudi Arabia

RECRUITING

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Riyadh, 12713, Saudi Arabia

RECRUITING

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Banská Bystrica, 974 01, Slovakia

RECRUITING

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Bratislava, 831 01, Slovakia

RECRUITING

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Bratislava, 841 08, Slovakia

RECRUITING

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Brezno, 977 01, Slovakia

RECRUITING

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Košice, 040 01, Slovakia

RECRUITING

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Košice, 04022, Slovakia

RECRUITING

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Martin, 036 01, Slovakia

RECRUITING

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Myjava, 90701, Slovakia

RECRUITING

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Nitra, 949 01, Slovakia

RECRUITING

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Nové Zámky, 940 01, Slovakia

WITHDRAWN

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Považská Bystrica, 017 01, Slovakia

RECRUITING

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Prešov, 080 01, Slovakia

WITHDRAWN

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Rimavská Sobota, 979 01, Slovakia

SUSPENDED

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Rimavská Sobota, 979 01, Slovakia

RECRUITING

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Svidník, 08901, Slovakia

RECRUITING

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Bloemfontein, 9301, South Africa

RECRUITING

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Centurion, 0157, South Africa

RECRUITING

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Durban, 4052, South Africa

RECRUITING

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Johannesburg, 2193, South Africa

RECRUITING

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KwaDukuza, 4449, South Africa

RECRUITING

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Panorama, 7500, South Africa

RECRUITING

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Parow, 7505, South Africa

RECRUITING

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Pietermaritzburg, 3201, South Africa

RECRUITING

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Somerset West, 7130, South Africa

RECRUITING

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Soweto, 2013, South Africa

RECRUITING

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Worcester, 6850, South Africa

WITHDRAWN

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Anyang-si, 14068, South Korea

RECRUITING

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Bucheon-si, 14754, South Korea

RECRUITING

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Busan, 47392, South Korea

RECRUITING

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Busan, 49201, South Korea

RECRUITING

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Busan, 49241, South Korea

RECRUITING

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Busan, 49267, South Korea

RECRUITING

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Cheongju-si, 28644, South Korea

RECRUITING

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Daegu, 42601, South Korea

RECRUITING

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Daejeon, 35015, South Korea

RECRUITING

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Gwangju, 61469, South Korea

RECRUITING

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Gwangmyeong, 14353, South Korea

RECRUITING

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Incheon, 21565, South Korea

RECRUITING

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Junggu, 22332, South Korea

RECRUITING

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Seongnam-si, 13620, South Korea

RECRUITING

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Seoul, 02841, South Korea

RECRUITING

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Seoul, 03080, South Korea

RECRUITING

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Seoul, 03722, South Korea

RECRUITING

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Seoul, 04763, South Korea

RECRUITING

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Seoul, 05505, South Korea

RECRUITING

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Seoul, 06351, South Korea

WITHDRAWN

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Seoul, 06591, South Korea

RECRUITING

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Seoul, 08308, South Korea

RECRUITING

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Uijeongbu-si, 11765, South Korea

RECRUITING

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Wŏnju, 26426, South Korea

TERMINATED

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Yangsan, 50612, South Korea

RECRUITING

Research Site

A Coruña, 15006, Spain

RECRUITING

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Barcelona, 08025, Spain

RECRUITING

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Barcelona, 08035, Spain

RECRUITING

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Barcelona, 08036, Spain

RECRUITING

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Lugo, 27004, Spain

RECRUITING

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Madrid, 28007, Spain

RECRUITING

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Madrid, 28027, Spain

RECRUITING

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Majadahonda, 28222, Spain

RECRUITING

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Seville, 41004, Spain

RECRUITING

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Seville, 41013, Spain

RECRUITING

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Seville, 41071, Spain

RECRUITING

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Valencia, 46010, Spain

RECRUITING

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Alingsås, 441 83, Sweden

WITHDRAWN

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Gothenburg, 413 46, Sweden

RECRUITING

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Jönköping, 55305, Sweden

RECRUITING

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Karlstad, 651 85, Sweden

RECRUITING

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Mölndal, SE431 80, Sweden

RECRUITING

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Stockholm, 112 81, Sweden

RECRUITING

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Stockholm, 118 83, Sweden

RECRUITING

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Stockholm, 171 64, Sweden

RECRUITING

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Stockholm, 18288, Sweden

RECRUITING

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Uppsala, 751 85, Sweden

RECRUITING

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Västerås, 721 89, Sweden

RECRUITING

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Changhua, 500, Taiwan

RECRUITING

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Kaohsiung City, 80756, Taiwan

RECRUITING

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Kaohsiung City, 81362, Taiwan

RECRUITING

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New Taipei City, 220, Taiwan

RECRUITING

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New Taipei City, 231, Taiwan

RECRUITING

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New Taipei City, 25160, Taiwan

RECRUITING

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Taichung, 40447, Taiwan

RECRUITING

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Taichung, 40705, Taiwan

RECRUITING

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Taichung, 433004, Taiwan

RECRUITING

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Taipei, 0116, Taiwan

RECRUITING

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Taipei, 10002, Taiwan

RECRUITING

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Taipei, 10449, Taiwan

RECRUITING

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Taipei, 110, Taiwan

RECRUITING

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Taipei, 11101, Taiwan

RECRUITING

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Taipei, 11217, Taiwan

RECRUITING

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Taipei, TAIWAN, Taiwan

RECRUITING

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Taoyuan District, 333, Taiwan

RECRUITING

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Yilan, 260, Taiwan

RECRUITING

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Yung Kang City, 71044, Taiwan

RECRUITING

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Bangkok, 10330, Thailand

RECRUITING

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Bangkok, 10400, Thailand

RECRUITING

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Bangkok, 10700, Thailand

RECRUITING

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Chiang Mai, 50200, Thailand

RECRUITING

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Hat Yai, 90110, Thailand

RECRUITING

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Khon Kaen, 40002, Thailand

RECRUITING

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Naimuang, 30000, Thailand

RECRUITING

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Pathum Thani, 12120, Thailand

RECRUITING

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Adana, 01060, Turkey (Türkiye)

RECRUITING

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Ankara, 06, Turkey (Türkiye)

RECRUITING

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Antalya, 07059, Turkey (Türkiye)

RECRUITING

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Antalya, 07100, Turkey (Türkiye)

RECRUITING

Research Site

Bursa, 16059, Turkey (Türkiye)

COMPLETED

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Center, 78200, Turkey (Türkiye)

RECRUITING

Research Site

Dinar, 03400, Turkey (Türkiye)

RECRUITING

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Eskişehir, 26480, Turkey (Türkiye)

RECRUITING

Research Site

Istanbul, 34668, Turkey (Türkiye)

WITHDRAWN

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Izmir, 35340, Turkey (Türkiye)

RECRUITING

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Kocaeli, 41380, Turkey (Türkiye)

RECRUITING

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Kütahya, 43100, Turkey (Türkiye)

RECRUITING

Research Site

Muğla, 48000, Turkey (Türkiye)

ACTIVE NOT RECRUITING

Research Site

Sivas, 58140, Turkey (Türkiye)

RECRUITING

Research Site

Chernivtsі, 58002, Ukraine

RECRUITING

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Ivano-Frankivsk, 76018, Ukraine

RECRUITING

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Kyiv, 01601, Ukraine

RECRUITING

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Kyiv, 02081, Ukraine

RECRUITING

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Kyiv, 03037, Ukraine

RECRUITING

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Kyiv, 03151, Ukraine

RECRUITING

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Kyiv, 03680, Ukraine

RECRUITING

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Kyiv, 04050, Ukraine

RECRUITING

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Ternopil, 46000, Ukraine

RECRUITING

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Ternopil, 46002, Ukraine

RECRUITING

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Uzhhorod, 88014, Ukraine

RECRUITING

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Vinnytsia, 21001, Ukraine

RECRUITING

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Vinnytsia, 21029, Ukraine

RECRUITING

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Zhytomyr, 100002, Ukraine

RECRUITING

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Airdrie, ML6 0JS, United Kingdom

RECRUITING

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Barnet, EN5 3DJ, United Kingdom

RECRUITING

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Cambridge, CB2 0AY, United Kingdom

WITHDRAWN

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Clydebank, G81 4DY, United Kingdom

RECRUITING

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Exeter, EX2 5DW, United Kingdom

RECRUITING

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Harefield, UB9 6JH, United Kingdom

RECRUITING

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Hastings, TN37 7RD, United Kingdom

RECRUITING

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High Wycombe, HP11 2TT, United Kingdom

WITHDRAWN

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Kent, BR6 8ND, United Kingdom

RECRUITING

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Kings Lynn, PE30 4ET, United Kingdom

RECRUITING

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Lincoln, LN2 5QY, United Kingdom

WITHDRAWN

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London, EC1M 6BQ, United Kingdom

COMPLETED

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London, SE5 9RS, United Kingdom

WITHDRAWN

Research Site

Middlesbrough, TS4 3BW, United Kingdom

RECRUITING

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Portsmouth, PO6 3LY, United Kingdom

RECRUITING

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Sheffield, S5 7AU, United Kingdom

WITHDRAWN

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Sunderland, SR4 7TP, United Kingdom

RECRUITING

Research Site

Wakefield, WF1 4DG, United Kingdom

RECRUITING

Research Site

Can Tho, 900000, Vietnam

RECRUITING

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Da Nang, 550000, Vietnam

RECRUITING

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Haiphong, 180000, Vietnam

RECRUITING

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Hanoi, 100000, Vietnam

RECRUITING

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Hà Nội, 100000, Vietnam

RECRUITING

Research Site

Ho Chi Minh City, 700000, Vietnam

RECRUITING

Research Site

Ho Chi Minh City, 70000, Vietnam

RECRUITING

Research Site

Ho Chi Minh City, 70000, Vietnam

NOT YET RECRUITING

Research Site

Hochiminh City, 700000, Vietnam

RECRUITING

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Hochiminh, 70000, Vietnam

RECRUITING

Research Site

Hồ Chí Minh, 700000, Vietnam

RECRUITING

Research Site

Huế, 530000, Vietnam

RECRUITING

Related Publications (1)

  • Bhattacharya CS, Ericsson H, Johansson S, Parkinson J, Boca SM, Yang Y, Heijer M, Housler G, Leonsson-Zachrisson M, Hartleib-Geschwindner J, Pizzato PE. The effect of severe renal impairment on the pharmacokinetics, safety and tolerability of balcinrenone. Br J Clin Pharmacol. 2025 Jul;91(7):1937-1946. doi: 10.1002/bcp.70017. Epub 2025 Feb 17.

MeSH Terms

Conditions

Heart Failure

Interventions

dapagliflozin

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Central Study Contacts

AstraZeneca Clinical Study Information Center

CONTACT

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: international, multi-centre, randomised, double-blind, parallel-group, double-dummy, active-controlled, event-driven
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 6, 2024

First Posted

March 13, 2024

Study Start

April 12, 2024

Primary Completion (Estimated)

June 11, 2027

Study Completion (Estimated)

June 11, 2027

Last Updated

April 27, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal Vivli.org. All requests will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure. "Yes", indicates that AZ are accepting requests for IPD, but this does not mean all requests will be approved.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA/PhRMA Data-Sharing Principles. For details of our timelines, please refer to our disclosure commitment at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure.
Access Criteria
When a request has been approved AstraZeneca will provide access to the anonymized individual patient-level data via secure research environment Vivli.org. A Signed Data Usage Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information.
More information

Locations