NCT06301932

Brief Summary

This observational study is to compare the effectiveness and outcomes of epidural analgesia in patients undergoing open hepatectomy: A propensity score matching analysis. The main question is: What is the superior method of pain control in open hepatectomy: epidural analgesia or intravenous PCA?

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
654

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2006

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2006

Completed
13 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2018

Completed
5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2023

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

March 4, 2024

Completed
4 days until next milestone

First Posted

Study publicly available on registry

March 8, 2024

Completed
Last Updated

March 12, 2024

Status Verified

March 1, 2024

Enrollment Period

13 years

First QC Date

March 4, 2024

Last Update Submit

March 7, 2024

Conditions

Epidural AnalgesiaPatient Controlled Analgesia

Keywords

Liver resectionPropensity score matching

Outcome Measures

Primary Outcomes (1)

  • Post-operative opioid consumption

    Post-operative opioid consumption at 24,48,72 hour

    Within 72 hours

Study Arms (2)

Epidural analgesia

Group of the patients received epidural analgesia

Procedure: Open liver resection

Non epidural analgesia

Group of the patients who did not received epidural analgesia

Procedure: Open liver resection

Interventions

Open liver resectionPROCEDURE

The definitions of liver resection and the type of hepatectomy were aligned with the anatomic classification of the Brisbane 2000 Terminology

Epidural analgesiaNon epidural analgesia

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

All patients more than 18 years old, who underwent an open hepatectomy between January 2007 - December 2018 at Maharay Nakhon Chiangmai Hospital

You may qualify if:

  • All gender age above 18 years old
  • Undergoing open liver resection surgery

You may not qualify if:

  • No documentation of the numerical rating scale (NRS)
  • Epidural failure

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Pianngarn I, Lapisatepun W, Kulpanun M, Chotirosniramit A, Junrungsee S, Lapisatepun W. The effectiveness and outcomes of epidural analgesia in patients undergoing open liver resection: a propensity score matching analysis. BMC Anesthesiol. 2024 Sep 2;24(1):305. doi: 10.1186/s12871-024-02697-1.

    PMID: 39223470DERIVED

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

March 4, 2024

First Posted

March 8, 2024

Study Start

January 1, 2006

Primary Completion

December 31, 2018

Study Completion

December 31, 2023

Last Updated

March 12, 2024

Record last verified: 2024-03

Data Sharing

IPD Sharing
Will not share