Perioperative Blood Transfusion in Open Liver Resection

NCT06189911 | Completed DMC

• 1 other identifier: ANE-2564-08020
• Study Type: observational
• Target: 1,201
• Locations: 0 countries
• Sites: N/A

Brief Summary

This observational study is specifically designed to identify the pre-operative risk factors that significantly contribute to perioperative packed red cell transfusions in open liver resection procedures. The main question it aims to answer are:

1. 1.What are the risk factors of peri-operative blood transfusion in open liver resection procedures
2. 2.What are the difference outcomes between patients who receive blood transfusion and the other group.

Conditions

Blood Loss, Postoperative

Keywords

liver resection; risk factors; blood transfusion; scoring system

Outcome Measures

Primary Outcomes (1)

• the pre-operative risk factors of perioperative packed red cell transfusions in open liver resection procedures.

  Significant risk factors for perioperative blood transfusion were determined by factors with a p-value \< 0.05 derived from the multivariable logistic regression analysis. This analysis facilitated adjustments for potential confounders to identify the independent risk factors associated with perioperative blood transfusion

  the transfusion of packed red cells during the operation and 48 hours after surgery

Study Arms (2)

transfused

Group of patients who received perioperative blood transfusions which was defined as the transfusion of packed red cells during the operation and 48 hours after surgery.

Procedure: Open liver resection

non-transfused

Group of patients who did not received perioperative blood transfusions

Procedure: Open liver resection

Interventions

Open liver resection PROCEDURE

The definitions of liver resection and the type of hepatectomy were aligned with the anatomic classification of the Brisbane 2000 Terminology

non-transfused; transfused

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All adult patients who underwent an elective open liver resection in our specialized hepato-biliary center from January 2006 through December 2017

You may qualify if:

• All genders age above 18 year old who underwent open liver resection from 2006-2017
• Elective open liver resection

You may not qualify if:

• Patients who death during the course of a surgical operation

Sponsors & Collaborators

• Chiang Mai University: lead

MeSH Terms

Conditions

Postoperative Hemorrhage

Condition Hierarchy (Ancestors)

Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Postoperative Complications

Study Officials

• Warangkana Lapisatepun, M.D.

  Chiang Mai University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: December 19, 2023
• First Posted: January 5, 2024
• Study Start: January 1, 2006
• Primary Completion: December 31, 2021
• Study Completion: January 1, 2023
• Last Updated: March 1, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share